Antimicrobial and in vitro antioxidant activity of Salvia officinalis L. against various re-emergent multidrug resistance microbial pathogens

Abstract

Routine antimicrobial testing was evaluated by using agar disk-diffusion testing method. The total phenolic, tota l flavonoid content, 2, 2'-a zino-bis (3-ethylbenzothiazoline-6-sulphonic acid) ( ABTS) and 1, 1 -diphenyl-2 -picrylhydra zyl ( D PPH) a ntioxida nt a ctivity were a lso performed on the extra ct/fra ctions. T he resu lts revealed fraction II possess maximum total phenolic and flavonoids content (330 ± 9.81 mg GAE/g and 106 ± 6.23 mg NE/g, respectively). Salvia officinalis L. extract and it's all fractions (I and II) exhibited antioxidant potential, but fraction II displayed significant DPPH and ABTS antioxidant potential, having an IC 50 valu e of 4 9.43 ± 6.21 µg/ml and 7 6.88 ± 7.42 µg/ml, respectively. T he fra ction II displayed substa ntial activity aga inst clinical isola tes for both Gram-positive bacteria (9 3 A, P 15 and P 9 Sta phylococ cus aure us), but against Gram-negative bacteria (715 Escherich ia coli and ETT 10 and P 34 Klebsiella sp.). There were no inhibition in the growth of the microbes. S. officinalis extract and fractions wou ld be useful to reduce the infectious diseases, ca used by va riou s re-emergent mu ltidrug resista nce microbial pa thogens or slow the a dvancement of different oxida tive stress related a ilments. However, further study is needed to isol ation a n d c ha r a cte riz a ti on of bio a cti ve mol ecu les, which ma y p rov ide po ten tia l be nefits so u rc e of na tu r a l a ntioxida nts and a ntimicrobia l properties.

Antibacterial and fungicidal activities of ethanol extracts of 38 species of plants

“…Biofilms containing solid dispersion of extract from Salvia officinalis L. had high antibacterial activity towards food pathogens S. aureus and E. coli (Salević & Lagaron 2019;Wali & Alam, 2019).…”