Antimicrobial, cytotoxic and antidiarrhoeal activity of Fimbristylis aphylla L.

Abstract

This study was conducted to evaluate the antimicrobial, cytotoxic and antidiarrhoeal activity of Fimbristylis aphylla L methanol extract. Preliminary phytochemical screenings with the crude extractives demonstrated the presence of alkaloids, glycosides, saponins and reducing sugars. In the disc diffusion antimicrobial sensitivity test, the crude extractive of the whole plant produced moderate to strong antimicrobial activity against the test microorganisms. The zone of inhibition was found within the range of 10.33-15.33 mm. The strongest zone of inhibition was found against Shigella dysenteriae. The extractive was found active against only a few number of test pathogens. In the cytotoxicity test by brine shrimp lethality bioassay, the extract exhibited moderate cytotoxic activity by 50 and 90% mortality rates as LC 50 and LC 90 values of 5.87 and 9.33 µg/ml respectively. A moderate dose-dependent antidiarrhoeal activity was found by the methanol extract of the plant.

Anti-diarrhea and anti-oxidant properties of Magnolol

“…Mice fasted for 24 h were randomly divided into five groups of ten mice each, diarrhoea was induced by administering 0.4 ml of castor oil orally to mice [10]. The positive control group was orally gavaged with loperamide hydrochloride (3 mg/kg), the model control group was orally administered saline (20 ml/kg), and magnolol-treated groups orally gavaged with varying doses of magnolol (25, 50 and 100 mg/kg BW) 30 min before castor oil administration.…”

Acute and subchronic toxicity profile of methanol extract of leaves of Fimbristylis miliacea (L.) Vahl

“…[9] , [10] . Some of the species of Fimbristylis has been reported to have medicinal properties including Fimbristylis dichotoma with antimicrobial and antioxidant activity [11] , Fimbristylis aphylla with antimicrobial, cytotoxic, and antidiarrheal activity [12] , Fimbristylis littoralis having antioxidant activity [13] .…”

Antidiarrhea and antioxidant activities of Honokiol extract from <i>Magnoliae officinalis cortex</i> in mice

“…A diarrhea model in mice was established by single oral administration (by gavage) of castor oil at dose of 20 ml/kg body weight (BW) [9]. Sixty mice were fasted for 24 h and randomly allocated into six equal groups based on BW.…”