This study was conducted to evaluate the antimicrobial, cytotoxic and antidiarrhoeal activity of Fimbristylis aphylla L methanol extract. Preliminary phytochemical screenings with the crude extractives demonstrated the presence of alkaloids, glycosides, saponins and reducing sugars. In the disc diffusion antimicrobial sensitivity test, the crude extractive of the whole plant produced moderate to strong antimicrobial activity against the test microorganisms. The zone of inhibition was found within the range of 10.33-15.33 mm. The strongest zone of inhibition was found against Shigella dysenteriae. The extractive was found active against only a few number of test pathogens. In the cytotoxicity test by brine shrimp lethality bioassay, the extract exhibited moderate cytotoxic activity by 50 and 90% mortality rates as LC 50 and LC 90 values of 5.87 and 9.33 µg/ml respectively. A moderate dose-dependent antidiarrhoeal activity was found by the methanol extract of the plant.

The present study was conducted according to the traditional uses of Mollugo oppositifolius L. by the kabiraj (traditional practioner) for the treatment of infectious diseases of the ill fated and poor people of Bangladesh. For this antioxidant, antimicrobial and biolethality potentials were conducted by methanol (MOME), ethanol (MOEE) and petroleum ether (MOPE) extractives of the suspected species.To determine the antioxidant activity the DPPH inhibition method was used. For antimicrobial test, antibacterial and antifungal sensitivities were performed by disc diffusion method and serial tube dilution method was carried out to determine the minimum inhibitory concentrations on some human pathogenic bacteria and fungi. For cytotoxicity test, brine shrimp lethality bioassay was conducted. Among the three crude extracts, MOEE produced more significant inhibition of DPPH (IC 50 ; 27 μg/ml); MOPE produced highest zone of inhibition against Bacillus subtilis (16.67 mm) and Microsporum spp. (16.0 mm). On the other hand, MOME produced mild cytotoxicity as 50% and 90% mortality (LC 50 and LC 90 ) 8.0 μg/ml and 85.12 μg/ml. ExtractionThe plant was subjected for shade dry. [7] The dried plant was then ground into coarse powder and subjected for hot extraction [8] with methanol, ethanol and petroleum ether by Soxhlet Apparatus (Quickfit, England). [9] Each extraction was carried out about 18 h and the extracts How to cite this article:

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Thrombous formation inside the blood vessels obstructs blood flow through the circulatory system leading hypertension, stroke to the heart, anoxia and so on. The complete deprivation of oxygen and infarction is a mode of cell death. Crude biologicals and their components possessing anti-thrombotic activity have been reported before. This study was aimed to investigate thrombolytic activity of ethanol extracts of four traditionally used medicinal plants. For this an in-vitro thrombolytic study was carried out along with streptokinase, and ethanol was taken as reference standard and negative control, respectively. The ethanol extracts (5 µg/µl) of Alpinia conchigera, Lannea grandis, Aglaonema hookerianum and Tridax procumbens 24.50%, 13.31%, 11.18%, and 8.70% clot lysis, respectively. Among the extracts studied Alpinia conchigera showed significant percent of clot lysis (24.50%) with reference to streptokinase (81.08%). Preliminary chemical group identification revealed the presence of alkaloids, glycosides, steroids, terpenoids, tannins and reducing sugars important secondary metabolites.