Antimicrobial Effect of Emodin Isolated from Cassia tora Linn. Seeds against Food-Borne Bacteria

Lee, Na Hyun; Lee, Sang Min; Song, Da; Yang, Ji Yeon; Lee, Hoi Seon

doi:10.3839/jabc.2013.030

Cited by 18 publications

(9 citation statements)

References 14 publications

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“…Phytochemicals may exhibit different modes of action against enterotoxigenic bacterial strains which range from interference with the phospholipoidal cell membranes, which has as a consequence of increasing the permeability profile and loss of cellular constituents, damage of the enzymes involved in the production of cellular energy and synthesis of structural components, and destruction or inactivation of genetic material [ 16 ]. The antimicrobial activities of emodin isolated from C. tora and its derivatives (anthraquinone, alizarin, and alizarin-3-methyliminodiacetic acid) against foodborne bacteria ( Bacillus cereus, Listeria monocytogenes, Staphylococcus intermedius, Salmonella typhimurium , and Shigella sonnei ) were described [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Attribution of antibacterial and antioxidant activity of Cassia tora extract toward its growth promoting effect in broiler birds

Sahu¹,

Koley²,

Sahu³

2017

Vet World

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Aim:The study was conducted to evaluate the attribution of antibacterial and antioxidant activity of methanolic extract of Cassia tora toward its growth promoting effect in broiler birds.Materials and Methods:A limit test was conducted for C. tora extract in Wistar albino rats. Phytochemical screening of methanolic extract of leaves of C. tora was carried out. In-vitro antibacterial activity was measured by disc diffusion method. 1-day-old Ven Cobb broiler birds (n=90) were randomly allocated into three groups consisting of three replicates with 10 birds in each group. The birds of group T1 (Control) received basal diet, whereas birds of group T2 (Standard) received an antibiotic (Lincomycin at 0.05% in feed). The birds of group T3 (Test) received Cassia tora extract (CSE) at 0.4 g/L in drinking water in addition to basal diet. The treatment was given to birds of all the groups for 6 weeks. Antioxidant activity of C. tora was determined in blood of broiler birds. Cumulative body weight gain, feed intake, feed conversion ratio (FCR), dressing percent, and organ weight factor were evaluated to determine growth performance in broiler birds.Results:Phytochemicals in C. tora were screened. Sensitivity to Escherichia coli and resistant to Staphylococcus aureus and Pseudomonas aeruginosa was observed in in-vitro antibacterial activity test. At the end of 6th week, antioxidant activity reflected significantly (p≤0.05) lower level of erythrocyte malondialdehyde and higher levels of reduced glutathione (GSH) and GSH peroxidase in broiler birds of group T2 and T3 as compared to broiler of group T1. Mean cumulative body weight gain of birds of T2 and T3 were significantly (p≤0.05) higher as compared to T1. Mean FCR of birds of group T3 decreased significantly than group T1.Conclusion:Supplementation of C. tora leaves extract at 0.4 g/L in drinking water improved growth performance in broiler birds due to its antimicrobial and antioxidant activity. Therefore, it could be used as an alternative to antibiotic growth promoter in poultry ration.

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Section: Discussionmentioning

confidence: 99%

Attribution of antibacterial and antioxidant activity of Cassia tora extract toward its growth promoting effect in broiler birds

Sahu¹,

Koley²,

Sahu³

2017

Vet World

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“…19,31 Moreover, emodin (2) possesses multiple pharmacological functions and has been widely used in the treatment of cancer, asthma, atherosclerosis, osteoarthritis, diabetes, Alzheimer's disease (AD), and hepatic disease. 19,29,30,32,33 In this study, emodin (2) displayed some antifungal activity against 6 plant pathogenic fungi, showing highest activity toward the pathogenic fungi B. maydis. The results of the mechanism of emodin (2) on the pathogen revealed that emodin (2) could affect the colony morphology, destroy cell membrane integrity and influence protein synthesis of the tested fungal cell.…”

mentioning

confidence: 70%

Two Polyketides Produced by Endophytic Penicillium citrinum DBR-9 From Medicinal Plant Stephania kwangsiensis and Their Antifungal Activity Against Plant Pathogenic Fungi

Luo

Zhen

Deng

et al. 2019

Natural Product Communications

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Endophytic fungi, especially those found in medicinal plants, are widely studied as producers of secondary metabolites of biotechnological interest. In this study, on the basis of an activity-directed isolation method and spectroscopic analysis, two active polyketides, citrinin (1) and emodin (2), were isolated and identified from the fermentation of the endophytic fungus Penicillium citrinum DBR-9. This fungus was isolated from the root tubers of the traditional Chinese medicinal plant Stephania kwangsiensis. In vitro antifungal assay showed that the two polyketides displayed significant inhibition on hypha growth of tested plant pathogenic fungi with IC 50 values ranging from 3.1 to 123.1 μg/mL and 3.0 to 141.0 μg/mL, respectively. In addition, the mechanism of the effects of emodin (2) on the pathogen revealed it could affect the colony morphology, destroy cell membrane integrity, and influence the protein synthesis of the tested fungal cell. This work is the first report of two polyketides-producing endophytic P. citrinum DBR-9 from the medicinal plant S. kwangsiensis. Our results present new opportunities to deeply understand the potential of these two polyketides as natural antifungal agents to control phytopathogens in agriculture.

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“…Kaempferol and luteolin have also been isolated from C. alata and C. fistula and displayed a strong DPPH scavenging activity [ 28 , 29 , 30 ]. On the other hand, anthraquinones were found as the major phenolic compounds present in Cassia species [ 31 ], while emodin, aloe-emodin, rhein, and chrysophanol are widely distributed in Cassia species such as C. tora [ 32 ], C. roxburghii [ 33 ], C. alata [ 34 , 35 ], C. obtuse [ 36 ], C. siamea [ 37 ], and C. angustifolia [ 38 ]. All of these previous findings are in good agreement with our present study that demonstrates C. timoriensis extract to possess high contents of flavonoids and phenolic compounds.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of Cassia timoriensis DC. Flowers

et al. 2021

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Despite being widely used traditionally as a general tonic, especially in South East Asia, scientific research on Cassia timoriensis, remains scarce. In this study, the aim was to evaluate the in vitro activities for acetylcholinesterase (AChE) inhibitory potential, radical scavenging ability, and the anti-inflammatory properties of different extracts of C. timoriensis flowers using Ellman’s assay, a DPPH assay, and an albumin denaturation assay, respectively. With the exception of the acetylcholinesterase activity, to the best of our knowledge, these activities were reported for the first time for C. timoriensis flowers. The phytochemical analysis confirmed the existence of tannins, flavonoids, saponins, terpenoids, and steroids in the C. timoriensis flower extracts. The ethyl acetate extract possessed the highest phenolic and flavonoid contents (527.43 ± 5.83 mg GAE/g DW and 851.83 ± 10.08 mg QE/g DW, respectively) as compared to the other extracts. In addition, the ethyl acetate and methanol extracts exhibited the highest antioxidant (IC50 20.12 ± 0.12 and 34.48 ± 0.07 µg/mL, respectively), anti-inflammatory (92.50 ± 1.38 and 92.22 ± 1.09, respectively), and anti-AChE (IC50 6.91 ± 0.38 and 6.40 ± 0.27 µg/mL, respectively) activities. These results suggest that ethyl acetate and methanol extracts may contain bioactive compounds that can control neurodegenerative disorders, including Alzheimer’s disease, through high antioxidant, anti-inflammatory, and anti-AChE activities.

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Antimicrobial Effect of Emodin Isolated from Cassia tora Linn. Seeds against Food-Borne Bacteria

Cited by 18 publications

References 14 publications

Attribution of antibacterial and antioxidant activity of Cassia tora extract toward its growth promoting effect in broiler birds

Attribution of antibacterial and antioxidant activity of Cassia tora extract toward its growth promoting effect in broiler birds

Two Polyketides Produced by Endophytic Penicillium citrinum DBR-9 From Medicinal Plant Stephania kwangsiensis and Their Antifungal Activity Against Plant Pathogenic Fungi

Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of Cassia timoriensis DC. Flowers

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