Antimicrobial effectiveness of parachlorophenol

Harrison, John W.; Madonia, John V.

doi:10.1016/0030-4220(70)90372-5

Cited by 37 publications

(3 citation statements)

References 10 publications

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“…Paramonochlorophenol (PMC) is a phenol-derived agent that exhibits broad antiseptic activity but also high toxicity. In order to reduce its cytotoxic effect while maintaining or even increasing its antimicrobial activity, combinations of PMC with other agents and vehicles and different application methods have been proposed 3,7,12,16,22,25 .…”

Section: Introductionmentioning

confidence: 99%

Susceptibility of some oral microorganisms to chlorhexidine and paramonochlorophenol

2004

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Since the use of antimicrobial agents is required in endodontic therapies, this study aimed at determining the minimum inhibitory concentrations (MICs) of chlorhexidine digluconate and paramonochlorophenol (PMC) against microorganisms commonly found in endodontic infections. Both agents were tested by agar dilution tests against Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Candida albicans, Prevotella intermedia, Porphyromonas gingivalis, Porphyromonas endodontalis, Prevotella denticola and Prevotella melaninogenica. The MIC of chlorhexidine ranged from 2.67 to 80.00 microg/ml, and the MIC of PMC from 46.67 to 213.33 microg/ml. The highest MIC value of PMC was detected for E. faecalis whereas E. coli was the most susceptible microorganism to this agent. The highest MIC values of chlorhexidine were observed for P. aeruginosa whereas E. coli and P. denticola were the most susceptible microorganisms to this agent. Since the MIC values observed are much lower than the concentrations currently used in the endodontic therapy, it is suggested that both agents are effective in reducing the microbiota in the root canal.

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Section: Introductionmentioning

confidence: 99%

Susceptibility of some oral microorganisms to chlorhexidine and paramonochlorophenol

2004

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“…At low concentrations, phenols show reduced toxicity when in contact with live tissue (Harrison & Madonia 1971) whilst their bactericidal effect is maintained (Harrison & Madonia 1970), thus being able to activate cell functions and to stimulate fibroblast activity (Tsukamoto et al . 1989).…”

Section: Introductionmentioning

confidence: 99%

Connective tissue responses to calcium hydroxide‐based root canal medicaments

Filho¹,

Silva²,

Leonardo³

et al. 1999

Int Endodontic J

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“…The results are similar with the finding of past studies. 8 calcium hydroxide combined with CMCP result in the formation of insoluble weak salt which may interfere with hydroxyl dissociation and reduce the long term activity. 1 CMCP is volatile liquid and rapidly lost from the paste.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of the Antibacterial Effect of Calcium Hydroxide Pastes Using Four Different Vehicles

M.R¹

2012

jemds

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AIM:The present study evaluated the antibacterial effect of calcium hydroxide pastes using four different vehicles namely propylene glycol, glycerin, distilled water and camphorated phenol. MATERIAL AND METHOD: Calcium hydroxide pastes prepared with two commonly used vehicles namely distilled water and camphorated phenol. The antibacterial activity of these pastes were tested against five anaerobic organism that can commonly occur in the infected root canal. The pastes were also prepared using two chemicals such as propylene glycol and glycerin. RESULTS AND CONCLUSION: The result of this study show that calcium hydroxide paste made with propylene glycol gives enhanced antibacterial action and sustains it for longer period of time. Propylene glycol being biological acceptable vehicle, it can be recommended for routine use as a vehicle over glycerin.

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Antimicrobial effectiveness of parachlorophenol

Cited by 37 publications

References 10 publications

Susceptibility of some oral microorganisms to chlorhexidine and paramonochlorophenol

Susceptibility of some oral microorganisms to chlorhexidine and paramonochlorophenol

Connective tissue responses to calcium hydroxide‐based root canal medicaments

Comparative Evaluation of the Antibacterial Effect of Calcium Hydroxide Pastes Using Four Different Vehicles

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