Antimicrobial efficacy of N -halamine coatings prepared via dip and spray layer-by-layer deposition

Denis-Rohr, Anna; Bastarrachea, Luis J.; Goddard, Julie M.

doi:10.1016/j.fbp.2015.06.002

Cited by 36 publications

(19 citation statements)

References 24 publications

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“…Therefore, TPU was selected as a representative material for food contact surfaces in this research. Previously, Julie M. Goddard's group worked intensively on applying N-halamines to food contact surfaces; however, they mainly focused on graing method and on some other materials including polypropylene (PP), 19,20 polyethylene (PE), 21 stainless steel, 22 etc. Although Yuyu Sun's team worked intensively on polyurethane, they also focused on graing method and their research targeted to biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

N-Halamine modified thermoplastic polyurethane with rechargeable antimicrobial function for food contact surface

et al. 2017

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Section: Introductionmentioning

confidence: 99%

N-Halamine modified thermoplastic polyurethane with rechargeable antimicrobial function for food contact surface

et al. 2017

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“…Biocidal efficacy may be further improved (reducing contact time required for 434 inactivation and increasing log reduction values of microbial populations) by increasing the 435 number of SMA and PEI bilayers[26, 42, 43]. The coating application process can be made 436 more commercially translatable by use of spray deposition as has been previously reported[60, 437 61], as well as use of commercially available heat curing lamps. The antimicrobial coating 438 showed self-healing properties upon heating after exposure to acid and alkali degradation 439conditions.…”

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confidence: 99%

Self-healing antimicrobial polymer coating with efficacy in the presence of organic matter

Bastarrachea

Goddard

2016

Applied Surface Science

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13A method to prepare a self-healing, antimicrobial polymer coating that retains efficacy against 14Escherichia coli O157:H7 in the presence of organic matter is reported. A coating composed of 15 branched polyethyleneimine (PEI) and styrene maleic anhydride copolymer (SMA) was applied 16 to a maleic anhydride functionalized polypropylene support. The chemistry of the polymer 17 coating was designed to impart hydrophobicity due to the styrene subunits, intrinsic 18 antimicrobial character (>99.9% reduction) from the cationic primary amine groups, and 19 enhanced antimicrobial character (>99.99% reduction) after chlorination of N-halamine forming 20 groups. Antimicrobial effectiveness was demonstrated under conditions of increasing organic 21 load. Up to 500 ppm horse serum, chlorinated coatings retained full antimicrobial character (> 22 load may support reducing microbial cross-contamination in food and biomedical industries. 29 30 KEYWORDS 31 Antimicrobial material, N-halamines, polycations, self-healing material, antimicrobial coating, 32 microbial cross-contamination. 33 34 3 Graphical Abstract 35 36 37

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“…The mainly used biocidal compounds include N ‐halamines ( N ‐chloramines and N ‐bromamines), quaternary ammonia salts, and heavy‐metal ions . N ‐halamines are famous and widely used biocidal groups since they are broad spectrum, rechargeable, very stable, and highly efficient .…”

Section: Introductionmentioning

confidence: 99%

“…Physical approaches such as layer‐by‐layer assembly and spin coating have been used to produce biocidal layers without the need of chemical reactions. However, the low surface tension of PE prevents the formation of durable biocidal layer‐by‐layer assembly technique since the low surface tension does not provide strong adhesion with biocides.…”

Section: Introductionmentioning

confidence: 99%

Preparation of silicone containing 2,2,6,6‐tetramethyl‐4‐piperidinol‐basedN‐chloramine for antibacterial polyethylene via interpenetration in supercritical carbon dioxide

Chen

Wang

Zhang

et al. 2019

J of Applied Polymer Sci

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Functionalization of polyethylene (PE) with powerful biocides through a friendly and efficient procedure is necessary to obtain extended applications. A novel CO 2 -philic 2,2,6,6-tetramethyl-4-piperidinol (TMP)-based N-chloramine silicone was synthesized via Pt-catalyzed silane alcoholysis between the Si H of poly(methylhydrosiloxane) and O H of TMP and followed by chlorination of amine N H originating from TMP to N Cl. The TMP-based N-chloramine silicone was interpenetrated into PE using supercritical carbon dioxide (scCO 2 ) as working solvent. It was shown that the thickness of the TMP-based N-chloramine silicone layer on PE can be easily controlled by the interpenetration pressure, reaching a maximum value of 70 nm at 28 mp. The synthetic procedures and the interpenetration results were characterized by Fourier transform infrared, scanning electron microscopy, and X-ray photoelectron spectroscopy. In contrast with pristine PE that did not show biocidal ability, the TMP-based N-chloramine silicone modified PE imparted powerful antibacterial abilities, exerting total kills of both Staphylococcus aureus and Escherichia coli of~10 7 cfu mL −1 in 30 min. The biocidal functionality was durable toward washings, storage, and ultraviolet exposure and the recoverability of lost chlorines was good. The interpenetration in scCO 2 tactic provides an environmentally friendly and universal approach to functionalize inert substrates due to no needs of harmful solvent and chemical linkages with biocides.The mainly used biocidal compounds include N-halamines (Nchloramines and N-bromamines), 6-17 quaternary ammonia salts, 18-25 and heavy-metal ions. 26,27 N-halamines are famous and widely used biocidal groups since they are broad spectrum, rechargeable, very stable, and highly efficient. 28,29 Their antibacterial capacity originates from the positively charged halamines (+1) that function as oxidizing agents to oxidize or destruct enzymatic and/or metabolic activities of microorganisms. N-halamines are formed by halogenation of imide/amide/amine N H to N Cl or N Br. The corresponding structures are called imide/amide/amine N-halamines with a stability order of imide < amide < amine structures. 30 As an amine N-halamine precursor, 2,2,6,6-tetramethyl-4-piperidinol (TMP) is stable due to its hindered structure, 31 resistant to photodegradation due to its regular function as ultraviolet (UV) stabilizer, 32 and lack Additional Supporting Information may be found in the online version of this article.

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Antimicrobial efficacy of N -halamine coatings prepared via dip and spray layer-by-layer deposition

Cited by 36 publications

References 24 publications

N-Halamine modified thermoplastic polyurethane with rechargeable antimicrobial function for food contact surface

N-Halamine modified thermoplastic polyurethane with rechargeable antimicrobial function for food contact surface

Self-healing antimicrobial polymer coating with efficacy in the presence of organic matter

Preparation of silicone containing 2,2,6,6‐tetramethyl‐4‐piperidinol‐basedN‐chloramine for antibacterial polyethylene via interpenetration in supercritical carbon dioxide

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