Antimicrobial photodynamic therapy to oral candidiasis not responsive to micafungin in a patient undergoing hematopoietic cell transplantation

Campos, Luana; Rezende, Sandra Bastos; Palma, Luiz Felipe; Hotsumi, Andressa Matucci; Tateno, Ricardo Yudi; Simões, Alyne; Okada, Larissa Yukari; Macedo, Maria Cristina Martins de Almeida

doi:10.1016/j.pdpdt.2021.102296

Cited by 11 publications

(9 citation statements)

References 6 publications

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“…The use of MB and TB dyes reduced the incidence of Candida albicans in the oral cavity (Rossoni et al, 2010;Campos et al, 2021) and controlled Fusarium spp. The efficiency of the dyes can be due to the damage caused by PhT to the fungal cell membrane (Paziani et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Nanoparticles and photodynamic therapy in the treatment and control of Alternaria alternata in wheat seeds

2022

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The expansion of wheat crops (Triticum spp.) to the Brazilian Cerrado highlights the need to use pathogen-free seeds. This study aimed at evaluating the efficacy of nanoparticles (NPs) and photodynamic therapy (PhT) in inhibiting the in vitro growth of the fungus Alternaria alternata, in its treatment and control in naturally contaminated wheat seeds, and in the physiological quality of the seeds. The efficacy of NPs (ZnOCl, ZnOCl:1Cu, ZnOCl:0.1Ag; ZnO:1Cu, ZnO, and ZnO:1Ag) and PhT using methylene blue (MB) and toluidine blue (TB) dyes was evaluated in inhibiting the mycelial growth of A. alternata and in the treatment and control of the pathogen in wheat seeds by evaluating germination, emergence, GSI, ESI, accelerated ageing, and health. All NPs at 2.5 and 5 mg mL-1 concentrations and the dyes MB, TB, MB + TB at 50 and 100 µmol L-1 inhibited mycelial growth and reduced the incidence of A. alternata in the seeds. The NP ZnO:1Ag at 5 mg mL-1 and the MB + TB dye at 100 µmol L-1 were the most effective in inhibiting mycelial growth. NPs and PhT did not affect the physiological quality of seeds and controlled A. alternata in wheat seeds, demonstrating potential use in the treatment and control of the pathogen in wheat seeds.

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Section: Resultsmentioning

confidence: 99%

Nanoparticles and photodynamic therapy in the treatment and control of Alternaria alternata in wheat seeds

2022

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“…The safety of this concentration has been fully confirmed in previous studies [ 42 ]. Additionally, this concentration of MB-aPDT is currently being clinically used [ 43 , 44 ]. Moreover, for the combined treatment group in this experiment, we selected 3% NaOCl for irrigation, as this concentration of the solution has been demonstrated to possess effective antimicrobial properties while maintaining its safety [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Sonic-assisted antibacterial photodynamic therapy: a strategy for enhancing lateral canal disinfection

Wang,

Lei,

Huang

et al. 2024

BMC Oral Health

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Background Bacterial infections in lateral canals pose challenges for root canal treatment. This in vitro study aims to evaluate the antibacterial efficacy of sonic-assisted methylene blue mediated antimicrobial photodynamic therapy (MB-aPDT) against Enterococcus faecalis (E. faecalis) in infected lateral canals. Methods Sixty-five premolars infected with E. faecalis in lateral canals were randomly divided into five groups (n = 13) and treated with : (1) 5.25% NaOCl (positive control); (2) Saline (negative control); (3) Sonic-assisted MB-aPDT; (4) 3% NaOCl + MB-aPDT; (5) 3% NaOCl + sonic-assisted MB-aPDT, respectively. The antibacterial efficacy was evaluated by the colony- counting method (CCM) and scanning electronic microscope (SEM). Results Both 5.25% NaOCl and the 3% NaOCl + sonic-assisted MB-aPDT exhibited the most effective while comparable antibacterial effects without significant statistical difference (P > 0.05). Furthermore, the antibacterial effect of the 3% NaOCl + MB-aPDT group was significantly higher compared to that of the sonic-assisted MB-aPDT group (P < 0.05). The SEM results demonstrated notable morphological alterations in E. faecalis across all experimental groups, except for the negative control group. Conclusion The concentration of NaOCl can be reduced to a safe level while preserving its antibacterial efficacy through the synergism with the sonic-assisted MB-aPDT in this study.

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“… 4 weeks; 22 weeks Hypopigmentation, no other side effects or pain. Oral candidiasis Freire F et al 47 In vitro study; in vivo study in a murine model 10 7 CFU/mL of suspension (OD570); 15 BALB/c mice C. albicans Methylene blue (MB); new methylene blue (NMB) Red diode laser 660 10; 20; 40; 60 J 5 days of daily treatment Potassium iodide (KI) Log reduction of CFU/mL: MB+KI (40 J): 2.31 log NMB (60 J): 1.77 log Reduction of mice bioluminescent photon flux (log 10 ): MB+KI (40J): 2 log NMB (60 J): 1 log NA NA Campos L et al 48 Case report 1 Candida spp. 0.01% MB Laser 660 178 1 session No ClC: 1/1 72 hours NA Chibebe JJ et al 49 In vivo experiment in Galleria mellonella model 16/group C. albicans Can14 (wild-type); Can37 (fluconazole-resistant) MB (1 mM) Red light 660±15 0.9 1 time Fluconazole (14 mg/kg) Can14: MB-PDT prolonged suivival.…”

Section: Role Of Photodynamic Therapy In Superficial Fungal Infectionsmentioning

confidence: 99%

“…A case report and an in vivo experiment in the Galleria mellonella model have described that MB-PDT could rapidly heal oral lesions caused by drug-resistant C. albicans strains and reduce the fungal burden by 0.2 log in the animal model. 48 , 49 However, the role of PDT in the prevention of drug resistance remains unclear.…”

Section: Role Of Photodynamic Therapy In Superficial Fungal Infectionsmentioning

confidence: 99%

“…Most studies have focused on only a few fungal diseases such as onychomycosis, oral candidiasis, and CBM that are commonly observed in clinical practice or are refractory to standard therapy. 15 , 31 , 48 , 57 , 63 Further studies are needed to gain deeper insight into the exact mechanisms underlying cell death and enhanced susceptibility of fungi to antifungal medications. 9 , 11 , 60 …”

Section: Current Limitations Of Photodynamic Therapy Used Against Fun...mentioning

confidence: 99%

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Photodynamic Therapy for the Treatment of Fungal Infections

Wu¹,

Hu²

2022

IDR

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Cutaneous fungal infections are common in humans and are associated with significant physical and psychological distress to patients. Although conventional topical and/or oral anti-fungal medications are commonly recommended treatments, drug resistance has emerged as a significant concern in this patient population, and safer, more efficacious, and cost-effective alternatives are warranted. Recent studies have reported effectiveness of photodynamic therapy (PDT) against fungal infections without severe adverse effects. In this review, we briefly discuss the mechanisms underlying PDT, current progress, adverse effects, and limitations of this treatment in the management of superficial and deep fungal infections.

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Antimicrobial photodynamic therapy to oral candidiasis not responsive to micafungin in a patient undergoing hematopoietic cell transplantation

Cited by 11 publications

References 6 publications

Nanoparticles and photodynamic therapy in the treatment and control of Alternaria alternata in wheat seeds

Nanoparticles and photodynamic therapy in the treatment and control of Alternaria alternata in wheat seeds

Sonic-assisted antibacterial photodynamic therapy: a strategy for enhancing lateral canal disinfection

Photodynamic Therapy for the Treatment of Fungal Infections

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