Antimicrobial Photodynamic Therapy Used as First Choice to Treat Herpes Zoster Virus Infection in Younger Patient: A Case Report

Teitelbaum, Susana; Azevedo, Luciane Hiramatsu; Bernaola-Paredes, Wilber Edison

doi:10.1089/photob.2019.4725

Cited by 13 publications

(5 citation statements)

References 17 publications

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“…PDI has been the subject of many in vitro and ex vivo studies, and it was already used in the inactivation of other viruses, such as in the treatment of Herpes Simplex Viruses (HSVs) [ 50 , 62 ], Human Papilloma Virus (HPV) [ 48 , 63 , 64 , 65 ], and Varicella–Zoster Viruses (VZVs) [ 66 ]. The efficiency of PDI for the treatment of bacterial lung infections has also been studied [ 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

Photoinactivation of Phage Phi6 as a SARS-CoV-2 Model in Wastewater: Evidence of Efficacy and Safety

et al. 2022

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The last two years have been marked by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. This virus is found in the intestinal tract; it reaches wastewater systems and, consequently, the natural receiving water bodies. As such, inefficiently treated wastewater (WW) can be a means of contamination. The currently used methods for the disinfection of WW can lead to the formation of toxic compounds and can be expensive or inefficient. As such, new and alternative approaches must be considered, namely, photodynamic inactivation (PDI). In this work, the bacteriophage φ6 (or, simply, phage φ6), which has been used as a suitable model for enveloped RNA viruses, such as coronaviruses (CoVs), was used as a model of SARS-CoV-2. Firstly, to understand the virus’s survival in the environment, phage φ6 was subjected to different laboratory-controlled environmental conditions (temperature, pH, salinity, and solar and UV-B irradiation), and its persistence over time was assessed. Second, to assess the efficiency of PDI towards the virus, assays were performed in both phosphate-buffered saline (PBS), a commonly used aqueous matrix, and a secondarily treated WW (a real WW matrix). Third, as WW is generally discharged into the marine environment after treatment, the safety of PDI-treated WW was assessed through the determination of the viability of native marine water microorganisms after their contact with the PDI-treated effluent. Overall, the results showed that, when used as a surrogate for SARS-CoV-2, phage φ6 remains viable in different environmental conditions for a considerable period. Moreover, PDI proved to be an efficient approach in the inactivation of the viruses, and the PDI-treated effluent showed no toxicity to native aquatic microorganisms under realistic dilution conditions, thus endorsing PDI as an efficient and safe tertiary WW disinfection method. Although all studies were performed with phage φ6, which is considered a suitable model of SARS-CoV-2, further studies using SARS-CoV-2 are necessary; nevertheless, the findings show the potential of PDI for controlling SARS-CoV-2 in WW.

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Section: Discussionmentioning

confidence: 99%

Photoinactivation of Phage Phi6 as a SARS-CoV-2 Model in Wastewater: Evidence of Efficacy and Safety

et al. 2022

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“…Thus, it is being reported as an effective choice for the treatment of lesions caused by viruses of the Herpes Family. 9,12 Melo et al reported a case in which aPDT was used in conjunction with antibiotics to treat bacterial infection associated with primary teeth in a 1-year-old baby diagnosed with Myelodysplastic Syndrome. The photosensitizer agent used was MB with a concentration of 0.01% associated with red wavelength low-power laser.…”

Section: Discussionmentioning

confidence: 99%

Graft‐versus‐host disease and herpes simplex virus oral injuries in onco‐hematological patient: Case report

Leidens

Ballardin

Leal

et al. 2021

Special Care in Dentistry

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Introduction: Graft-versus-host disease (GVHD) is a systemic complication that can affect patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) and the mouth is one of the places affected by the disease (oGVHD). Topical corticosteroids are used to control the painful symptoms, causing a local immunosuppression and increasing the risk for opportunistic infections.Objective: This study aims to report a case of a 42-year-old woman, diagnosed with Chronic Myeloid Leukemia, who developed oGVHD and herpes simplex virus (HSV) infection after HSCT. Case Report: oGVHD was confirmed by incisional biopsy and viral infection by HSV types 1 and 2 was confirmed by PCR. Topical and systemic corticotherapy and antiviral therapies were instituted. The immunosuppression intensified viral infection and antimicrobial photodynamic therapy (aPDT) was instituted as an adjuvant treatment. aPDT application, along with the patient's immune recovery, antivirals and corticosteroids resulted in clinical improvement of oral lesions. Final Considerations: This study highlights aPDT as an effective adjunct therapy in the local treatment of opportunistic infections in onco-hematological patients.

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“…Notably, there were no reports of spot recurrence during the 7-month follow-up period. Additionally, the study investigated bacterial species ( Actinomycetemcomitans , P. gingivalis , P. intermedia , P. melaninogenica , and P. nigrescens ) and found a significant reduction (22%) in the overall prevalence of bacteria post-treatment, particularly for P. intermedia , which was not detected in any of the samples [ 69 , 70 ]…”

Section: Applications Of Pdt In Pediatric Dentistrymentioning

confidence: 99%

Application of Photodynamic Therapy in Pediatric Dentistry: Literature Review

Silva,

Lunardi,

Barros

et al. 2023

Pharmaceutics

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Microbiological control of dental pathologies presents a significant clinical challenge for dental surgeons, particularly considering drug-resistant microorganisms. To address this issue, Antimicrobial Photodynamic Therapy (PDT) has emerged as an effective and complementary technique for microbial reduction. This therapy involves the application of a photosensitizer dye (PS) either topically or systemically, followed by exposure to low-power lasers with appropriate visible light wavelengths. PDT has found a valuable place in dentistry across various specialties, including surgery, periodontics, endodontics, dentistry, implantology, orthodontics, and pediatrics. In the realm of pediatric dentistry, managing microorganisms during dental treatments has become a major challenge. Considering its promising results and ease of application, Photodynamic Therapy presents an interesting alternative for clinical practice. However, it is important to note that specific protocols must be followed for each application, encompassing the type of photosensitizer, concentration, pre-irradiation time, light type, wavelength, energy, power, and mode of light delivery. Researchers have been steadily refining these protocols to facilitate PDT’s integration into clinical practice. The objective of this review is to describe in which procedures and oral health problems in children PDT can be applied. In this sense, we list what the literature brings about the possibilities of applying PDT in a pediatric dentistry clinic.

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Antimicrobial Photodynamic Therapy Used as First Choice to Treat Herpes Zoster Virus Infection in Younger Patient: A Case Report

Cited by 13 publications

References 17 publications

Photoinactivation of Phage Phi6 as a SARS-CoV-2 Model in Wastewater: Evidence of Efficacy and Safety

Photoinactivation of Phage Phi6 as a SARS-CoV-2 Model in Wastewater: Evidence of Efficacy and Safety

Graft‐versus‐host disease and herpes simplex virus oral injuries in onco‐hematological patient: Case report

Application of Photodynamic Therapy in Pediatric Dentistry: Literature Review

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