Antimicrobial susceptibility of 3931 organisms isolated from intensive care units in Canada: Canadian National Intensive Care Unit Study, 2005/2006

Detection of Plasmid-Mediated KPC-Producing Klebsiella pneumoniae in Ottawa, Canada: Evidence of Intrahospital Transmission

“…Previous national surveillance data from intensive care units across Canada revealed no in vitro resistance to meropenem among K. pneumoniae isolates, with the highest identified MIC being 0.25 mg/liter (18). To our knowledge, these are the first published cases of KPC-producing K. pneumoniae infections in Canada, including evidence of intrahospital transmission.…”

In vitro activity of WQ-3810, a novel fluoroquinolone, against multidrug-resistant and fluoroquinolone-resistant pathogens

“…The emergence of QRSP has been reported in recent years, although the global incidence of QRSP has been documented to be low (ca. 1%) [2,21]. QRSP has become a serious problem in specific regions, e.g.…”

“…However, excessive use of fluoroquinolones has led to the emergence of fluoroquinolone-resistant (FQR) bacteria. The prevalence and spread of FQR bacteria have been reported globally in a variety of important human pathogens, including Escherichia coli, Streptococcus pneumoniae and meticillin-resistant Staphylococcus aureus (MRSA), and have thus become major public health concerns over the past years [2,3]. In addition, a high rate of FQR Neisseria gonorrhoeae isolated among patients with sexually transmitted infections has been the focus of much attention [4].…”

Antimicrobial Susceptibility of Bloodstream Isolates of <i>Staphylococcus aureus</i>: Global Results from the Tigecycline Evaluation and Surveillance Trial, 2004-2008

“…MRSA bacteraemia has been shown to be more life threatening than MSSA due to the inferior efficacy of vancomycin which remains the standard treatment of serious MRSA infections in many countries (Turnidge et al, 2009). Against this background, continuing surveillance of the antimicrobial susceptibility of bacterial pathogens, including S. aureus and the development and characterization of new compounds are essential (Zinner, 2005;Zhanel et al, 2008).…”