Antimycobacterial Anthraquinone-Chromanone Compound and Diketopiperazine Alkaloid from the Fungus<i>Chaetomium globosum</i>KMITL-N0802

Kanokmedhakul, Somdej; Kanokmedhakul, Kwanjai; Phonkerd, Nutchanat; Soytong, Kasem; Kongsaeree, Palangpon; Suksamrarn, Apichart

doi:10.1055/s-2002-34415

Cited by 96 publications

(72 citation statements)

References 6 publications

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“…In plants, anthraquinones are found in a wide range of species, especially in the plant families Rubiaceae, Polygonaceae, Rhamnaceae,Fabaceae, and Xanthorrhoeaceae [19]- [22]. Anthraquinone compounds and plants that contain them are widely used as mild laxatives [23], [24].…”

Section: Anthraquinonesmentioning

confidence: 99%

Screening of Anthraquinones and Assessment of Antimicrobial Activities of Ethanol Extracts of AdansoniadigitataL., Sudan

2016

IJSR

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Abstract:The aim of the study was to investigate anthraquinones and to determine the antimicrobial activity of different extracts of Adansoniadigitata L., a plant used by Sudanese communities to treat various ailments such as diarrhea and microbial infections. The anthraquinones were screened qualitatively. The presences of anthraquinones were detected in ethanol extracts along with acetone and ethyl acetate fractions of both fruits fibers and fruits cover of A. digitata. The fruits fibers and fruits cover extracts were screened for antimicrobial activityagainst Gram-positive (Bacillus subtilis and Staphylococcus aureus), and Gram-negative bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris and Klebsiella pneumoniae), and two fungi (Candida albicans and Aspergillus niger)using agar well diffusion method. Results showed that the fruits covers extract was exerted highest activity on bacterial agents tested compared to fruits fibers extract, and fruits fibers extract was the most effective against fungi (A. niger), while both extracts were not active against C. albicans.Fruits cover extract at concentration of 100 μg / ml showed 25 mm diameter zone of inhibition against P.vulgaris. This was followed by 23, 22 and 21 mm zone of inhibition against B. subtilis, K. pneumoniae and S. aureus. TLC analysis revealed the presence of two anthraquinones compounds in the acetone extract of the fruits cover.

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Section: Anthraquinonesmentioning

confidence: 99%

Screening of Anthraquinones and Assessment of Antimicrobial Activities of Ethanol Extracts of AdansoniadigitataL., Sudan

2016

IJSR

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“…Therefore, blocking this receptor may offer a novel alternative for controlling HIV infections although other viruses may benefit from such a treatment [91]. Screening a library of spiro-diketopiperazines compound 913 57 ( Figure 4) was identified blocking the binding of macrophage inflammatory protein-1 to CCR5 (IC 50 2 nM) inhibiting the replication of some but not all HIV-1 variants [92].…”

Section: Some Diketopiperazines Have Also Anti-viral Activitiesmentioning

confidence: 99%

“…This unusual antibiotic contains a bridged diketopiperazine and the rare N-oxide moiety. The cyclo(L-Ala-L-Try) derivative echinuline 23 isolated from Aspergillus amstelodami [49] has been found to be active against Mycobacterium tuberculosis [50]. From several Penicillium species roquefortine C 24 has been isolated.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Biofilm Inhibiting Diketopiperazines

Carvalho

Abraham²

2012

CMC

143

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“…Previous report of Kanokmedhakul et al (2002) stated that chaetomanone A was firstly extracted from C. globosum strain N0802 and it also exhibited antitubercular activity against Mycobacterium tuberculosis, a major human disease. But there are no reports on chaetomanone A against plant pathogenic fungi.…”

Section: Evaluation Of Microbial Elicitors To Control Tomato Wiltmentioning

confidence: 99%

Evaluation of microbial elicitors to induce plant immunity for tomato wilt

Soytong¹,

Charoenporn²,

Kanokmedhakul³

2013

Afr. J. Microbiol. Res.

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The bioactive compounds of Chaetoglobosin C, chaetomanone A and trichotoxin mixture used as microbial elicitors to elicit -tomatine in tomato was investigated. The -tomatine was detected from tomato seedlings var. Sida sprayed with chaetoglobosin C, chaetomanone A and trichotoxin mixture, followed by the inoculation with Fusarium oxysporum f sp lycopersici. Results show that disease immunity on treated tomato seedlings with chaetoglobosin C, chaetomanone A and trichotoxin mixture at concentration 50 ug/ml after 10 days were 44.97, 35.18 and 39.43%, respectively, while prochloraz showed disease immunity of 29.95%. The stems and leaves of tomato were extracted and spotted on TLC yielded green spot which showed Rf = 0.23 as same as a spot of standard -tomatine. Tomato extracts were subjected into vial and analyzed for -tomatine in HPLC system. Tomato treated with chaetoglobosin C, chaetomanone A and trichotoxin mixture at 15 days expressed -tomatine quantity as 207.87, 254.25, and 205.04 ug/g which significantly were higher than for prochloraz and the inoculated control whose -tomatine quantity were 131.56 and 77.46 ug/g, respectively. It showed that chaetoglobosin C, chaetomanone A and trichotoxin mixture could induce -tomatine in tomato plants implying disease immunity against Fusarium wilt of tomato var. Sida through phytoalexin production. The bioactive compounds were tested for their efficacies to induce immunity in tomato wilt in vivo. The results reveal that all bioactive compounds at concentration 10, 50 and 100 µg/ml could induce plant immunity in tomato between 53.80-65.15% which significantly had higher plant disease immunity than prochloraz (26.73%) indicating that these bioactive compounds play an important role as microbial elicitors.

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Antimycobacterial Anthraquinone-Chromanone Compound and Diketopiperazine Alkaloid from the FungusChaetomium globosumKMITL-N0802

Cited by 96 publications

References 6 publications

Screening of Anthraquinones and Assessment of Antimicrobial Activities of Ethanol Extracts of AdansoniadigitataL., Sudan

Screening of Anthraquinones and Assessment of Antimicrobial Activities of Ethanol Extracts of AdansoniadigitataL., Sudan

Antimicrobial and Biofilm Inhibiting Diketopiperazines

Evaluation of microbial elicitors to induce plant immunity for tomato wilt

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