Antimycobacterial potential of resorcinol type lipid isolated from Chaetomium cupreum, an endophytic fungus from Mussaenda luteola

Abstract

<p class="Abstract">An endophytic fungus <em>Chaetomium cupreum</em> was isolated from the ornamental plant <em>Mussaenda luteola</em>. A known metabolite named resorcinol type of lipid (compound 1) was isolated using column chromatography and structurally elucidated by spectroscopic studies includes UV-Vis, FT-IR, NMR, MS analysis and comparing with the existing data. The compound 1 was evaluated for antimycobacterial potential by microtitre plate alamar blue assay against Mycobacterium tuberculosis H37Rv (ATCC27294). It also estimated for DPPH free radical scavenging and antibacterial (agar well diffusion method) potentials. Compound 1 revealed to have significant inhibition of Mycobacterium with MIC of 6.3 µg/mL which is similar to the standard streptomycin drug. It also exhibited good DPPH free radical scavenging potential of 84.5 ± 0.4% and maximum inhibition of both <em>E. coli</em> (ATCC 25922) as well as S. aureus (ATCC 25923). Thus, endophytic fungus <em>C. cupreum</em> from <em>Mussaenda luteola</em> could be a potential source of novel lead antimicrobial agents for drug discovery.</p><p class="Abstract"><strong>Video Clip of Methodology</strong>:</p><p class="Abstract">9 min 43 sec: <a href="https://www.youtube.com/v/jVjoCzsGMg8">Full Screen</a> <a href="https://www.youtube.com/watch?v=jVjoCzsGMg8">Alternate</a></p>

Antimicrobial Activities of Endophytic Fungal Crude Extracts Isolated from Cashew Tree (Anacardium occidentale)

“…Penicillium sp was active against tested bacteria and had activity against fungi, and this was also reported to produce a range of medicinally important metabolites including antimicrobials (Lucas et al 2007) and antifungals (Nicoletti et al 2007). Daldinia sp has got partially active antibacterial activities since this plant was reported to possess many therapeutic properties like antimicrobial, cytotoxicity and anti-inflammatory activities (Shylaja et al 2018). Only one endophytic fungus Aspergillus sp from diseased plants showed activities against all the tested microbes.…”

Natural Products from Endophytic Fungi Associated with Rubiaceae Species

“…Recently, four secondary metabolites from C. cupreum associated with Mussaenda luteola were characterized as resorcinol (201), 6-(heptacosa-18 Z enyl)-2-(18"hydroxyl-1" enyl-19" oxy)-3-hydroxybenzoquinone (202), (3β-5α-dihydroxy-6β-phenylacetyloxy-ergosta-7, 22-diene) (203) and 2-dodecanol (204) (Figure 15) [144,145].…”

Antimicrobial activity of volatile compounds produced by endophytic fungi associated with Ocimum sanctum

“…Many endophytes capable of secreting bioactive compounds that may be used against pathogenic microorganisms (Daoud et al, 2013). The endophytic fungi Chaetomium cupreum (isolated from Mussaenda luteola; Shylaja et al, 2018), Cryptosporiopsis ericae (isolated from Coptis chinensis; Zhang et al, 2018), Phoma sp. (isolated from Fucus serratus; Hussain et al, 2014), Nigrospora sphaerica URM-6060 (isolated from Indigofera suffruticosa; Santos et al, 2015), Trichoderma virens and Aspergillus terreus (isolated from Cyperaceae sp.…”