ANTINEOPLASTIC ACTIVITY OF CULTURED BLUE‐GREEN ALGAE (CYANOPHYTA)<sup>1</sup>

Patterson, Gregory M. L.; Baldwin, Cynthia L.; Bolis, Christine M.; Caplan, Faith R.; Karuso, Helen; Larsen, Linda K.; Levine, Ira A.; Moore, Richard E.; Nelson, Carrie S.; Tschappat, Kathryn D.; Tuang, Grace D.; Furusawa, Eiichi; Furusawa, Shinobu; Norton, Ted R.; Raybourne, Richard B.

doi:10.1111/j.0022-3646.1991.00530.x

Cited by 110 publications

(70 citation statements)

References 27 publications

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“…These compounds include tubericidin and toyocamycin, both of which have also been found in Streptomyces (Barchi et al, 1983;Patterson et al, 1991) and new unique macrolides such as scytophycin B (Fig. 2) isolated from Scytonema pseudohofmanni.…”

Section: Toxins and Pharmacologically Active Compoundsmentioning

confidence: 94%

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Microalgae as sources of pharmaceuticals and other biologically active compounds

1995

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In the last decade the screening of microalgae, especially the cyanobacteria (blue-green algae), for antibiotics and pharmacologically active compounds has received ever increasing interest. A large number of antibiotic compounds, many with novel structures, have been isolated and characterised. Similarly many cyanobacteria have been shown to produce antiviral and antineoplastic compounds. A range of pharmacological activities have also been observed with extracts of microalgae, however the active principles are as yet unknown in most cases. Several of the bioactive compounds may find application in human or veterinary medicine or in agriculture. Others should find application as research tools or as structural models for the development of new drugs. The microalgae are particularly attractive as natural sources of bioactive molecules since these algae have the potential to produce these compounds in culture which enables the production of structurally complex molecules which are difficult or impossible to produce by chemical synthesis.

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Section: Toxins and Pharmacologically Active Compoundsmentioning

confidence: 94%

“…Moore et al, 1988;Kellam & Walker, 1989;Patterson et al, 1991). Not only are the microalgae proving to be valuable sources of novel biologically active molecules, but since many can be cultured they also have the potential advantage over macroalgae (and invertebrates) of being easier to 5 culture commercially.…”

Section: Introductionmentioning

confidence: 99%

Microalgae as sources of pharmaceuticals and other biologically active compounds

1995

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“…The strain was deposited as ATCC 53789, and its potential use in the pharmaceutical and agricultural field was patented (14). The structure of the active compound, named cryptophycin 1, was determined later by Moore and coworkers (2,38), who isolated it from Nostoc strain GSV224, which was discovered to be a cryptophycin producer during screening for cyanobacterial anticancer activity at the University of Hawaii (20,25). Cryptophycin 1 exerts antiproliferative and antimitotic activity by binding to the ends of the microtubules, thus blocking the cell cycle at the metaphase of mitosis.…”

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confidence: 99%

Evaluation ofNostocStrain ATCC 53789 as a Potential Source of Natural Pesticides

Biondi

Piccardi

Margheri

et al. 2004

Appl Environ Microbiol

104

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The cyanobacterium Nostoc strain ATCC 53789, a known cryptophycin producer, was tested for its potential as a source of natural pesticides. The antibacterial, antifungal, insecticidal, nematocidal, and cytotoxic activities of methanolic extracts of the cyanobacterium were evaluated. Among the target organisms, nine fungi (Armillaria sp., Fusarium oxysporum f. sp. melonis, Penicillium expansum, Phytophthora cambivora, P. cinnamomi, Rhizoctonia solani, Rosellinia, sp., Sclerotinia sclerotiorum, and Verticillium albo-atrum) were growth inhibited and one insect (Helicoverpa armigera) was killed by the extract, as well as the two model organisms for nematocidal (Caenorhabditis elegans) and cytotoxic (Artemia salina) activity. No antibacterial activity was detected. The antifungal activity against S. sclerotiorum was further studied with both extracts and biomass of the cyanobacterium in a system involving tomato as a host plant. Finally, the herbicidal activity of Nostoc strain ATCC 53789 was evaluated against a grass mixture. To fully exploit the potential of this cyanobacterium in agriculture as a source of pesticides, suitable application methods to overcome its toxicity toward plants and nontarget organisms must be developed.

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“…Cryptophycin 1 was isolated from Nostoc sp. GSV224 in Moore's lab 19 as anticancer agent. It has an IC 50 of 5 pg ml -1 against KB human nasopharyngeal cancer cells, and 3 pg ml -1 against LoVo human colorectal cancer cells, and thus it was found to be 100-1000 times more potent than currently available anticancer drugs; for example, taxol or vinblastine.…”

Section: Anticancer Activitymentioning

confidence: 99%

Cyanobacteria: an emerging source for drug discovery

et al. 2011

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The c group of Gram-negative gliding bacteria, has a long history of cosmopolitan occurrence. It has great biodiversity despite the absence of sexual reproduction. This wide biodiversity may be reflected in the wide spectrum of its secondary metabolites. These cyanobacterial secondary metabolites are biosynthesized by a variety of routes, notably by non-ribosomal peptide synthetase or polyketide synthetase systems, and show a wide range of biological activities including anticancer, antibacterial, antiviral and protease inhibition activities. This high degree of chemical diversity in cyanobacterial secondary metabolites may thus constitute a prolific source of new entities leading to the development of new pharmaceuticals.

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ANTINEOPLASTIC ACTIVITY OF CULTURED BLUE‐GREEN ALGAE (CYANOPHYTA)¹

Cited by 110 publications

References 27 publications

Microalgae as sources of pharmaceuticals and other biologically active compounds

Microalgae as sources of pharmaceuticals and other biologically active compounds

Evaluation ofNostocStrain ATCC 53789 as a Potential Source of Natural Pesticides

Cyanobacteria: an emerging source for drug discovery

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ANTINEOPLASTIC ACTIVITY OF CULTURED BLUE‐GREEN ALGAE (CYANOPHYTA)1

Cited by 110 publications

References 27 publications

Microalgae as sources of pharmaceuticals and other biologically active compounds

Microalgae as sources of pharmaceuticals and other biologically active compounds

Evaluation ofNostocStrain ATCC 53789 as a Potential Source of Natural Pesticides

Cyanobacteria: an emerging source for drug discovery

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Product

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ANTINEOPLASTIC ACTIVITY OF CULTURED BLUE‐GREEN ALGAE (CYANOPHYTA)¹