Antineoplastic effect of pectic polysaccharides from green sweet pepper (Capsicum annuum) on mammary tumor cells in vivo and in vitro

Adami, Eliana Rezende; Corso, Christopher D.; Turin-Oliveira, Natalia Mulinari; Galindo, Claudia; Milani, Letícia; Stipp, Maria Carolina; Nascimento, Georgia Erdmann do; Chequin, Andressa; Silva, Luísa Mota da; Andrade, Sérgio Faloni de; Dittrich, Rosângela Locatelli; Queiroz-Telles, José Ederaldo; Klassen, Giseli; Ramos, Edneia A.S.; Cordeiro, Lucimara M.C.; Acco, Alexandra

doi:10.1016/j.carbpol.2018.08.071

Cited by 34 publications

(13 citation statements)

References 46 publications

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“…(ervilhaca de leite) mostrou que estes foram capazes de reduzir o peso do tumor só-lido de Ehrlich em camundongos (18), bem como uma pectina dos frutos de Feronia limonia (ou F. elephantum, maçã-de-lima) teve ação inibitória no crescimento de células tumorais no modelo tumoral ascítico de Ehrlich (19). Adicionalmente, estudos em nosso grupo de pesquisa evidenciaram efeitos antitumorais de polissacarídeos extraídos do pimentão verde (20), do vinho tinto cabernet franc (21) e do próprio jambo (7), tanto in vitro (células de tumor mamário) quanto in vivo (carcinoma de Ehrlich e Walker-256), corroborando com os dados da Figura 1.…”

Section: Resultsunclassified

“…No entanto, para conclusão acerca do efeito dos PJ no processo inflamatório, outros parâmetros precisariam ser avaliados, especialmente citocinas. A influência de polissacarídeos de outras fontes nos níveis tumorais e plasmáticos de citocinas já foi descrita: elevação do fator de necrose tumoral α (TNF-α) em tumor Walker-256 de ratos tratados com polissacarídeos extraídos do vinho tinto cabernet franc ( 21) e elevação de interleucina (IL)-6 em tumor de Ehrlich (20). Adicionalmente, para testar os efeitos da combinação de PJ + MTX na inflamação e em outras vias de transdução celular, menores doses de ambos os compostos poderiam ser testadas, a fim de confirmar se suas ações são sinérgicas ou complementares.…”

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Efeitos De Polissacarídeos Do Jambo No Modelo Tumoral Solido De Ehrlich Em Camundongos

Seko¹,

Mendonça²,

Turin-Oliveira³

et al. 2020

Infarma

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O tratamento de câncer envolve fármacos que podem causar diversos efeitos colaterais. Assim, existe uma busca por tratamentos com menor toxicidade. Dentre os compostos estudados, os polissacarídeos de plantassuperiores destacam‑se como antioxidantes e antitumorais. O objetivo deste trabalho foi avaliar os efeitos antitumorais in vivo de polissacarídeos do jambo (Syzygium jambos (L.) Alston) e da associação destes com um tratamento padrão (metotrexato), utilizando como ferramenta o tumor sólido de Ehrlich em camundongos. Os grupos de camundongos inoculados com células tumorais foram: I) Controle negativo (água destilada), II) PJ 100 (polissacarídeos do jambo, 100 mg/kg), III) PJ 150, IV) PJ 250, V) Controle positivo (metotrexato dose menor – MTX 1,5 mg/kg), VI) Controle positivo (MTX dose maior – 2,5 mg/kg) e VII) PJ 250 + MTX 2,5 mg/kg. Houve redução no peso tumoral pelos PJ, principalmente com PJ 250 (‑45%), semelhante à inibição causada pelo MTX 2,5 (‑43%), enquanto a associação PJ+MTX não potencializou esta inibição. No tecido tumoral, os PJ reduziram os níveis de parâmetros inflamatórios em relação ao controle negativo, porém a redução não foi dose‑dependente. Os PJ elevaram a atividade da superóxido dismutase tumoral e não causaram alterações hematológicas. Os PJ também não causaram danos relevantes ao fígado, órgão‑alvo de toxicidade de fármacos. Conclui‑se que os PJ reduziram o crescimento do tumor de Ehrlich, provavelmente por modulação do processo inflamatório no microambiente tumoral, evidenciando o potencial adjuvante dos PJ em quimioterapias. Assim, seus efeitos deverão ser ainda investigados em outros modelos tumorais e tipos celulares.

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Section: Resultsunclassified

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Efeitos De Polissacarídeos Do Jambo No Modelo Tumoral Solido De Ehrlich Em Camundongos

Seko¹,

Mendonça²,

Turin-Oliveira³

et al. 2020

Infarma

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“…The pectin in sweet pepper increases interleukin-6 in tumors and can regulate inflammation and angiogenesis to exert antitumor effects ( 40 ). Sweet peppers also contain capsaicin that can change the expression of several genes involving cancer cell survival, growth retardation, angiogenesis, and metastasis.…”

Section: Discussionmentioning

confidence: 99%

Solanaceous Vegetables and Colorectal Cancer Risk: A Hospital-Based Matched Case-Control Study in Northeast China

Liu

Jiang

et al. 2021

Front. Nutr.

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Background: Dietary factors are regarded as an essential influence in changing colorectal cancer (CRC) risk. However, there is no clear conclusion of the relationship between solanaceous vegetables and colorectal cancer at present. The study aimed to evaluate the intake of solanaceous vegetables in relation to colorectal cancer risk among the Northeast Chinese population.Methods: We carried out a hospital-based case-control study in three hospitals in Northeast China from 2009 to 2011. The study finally included 833 patients with CRC and 833 controls matched separately according to age, gender, and city of residence. We applied a structural questionnaire to collect demographic characteristics and dietary information by face-to-face interview and adopted conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Stratified analyses were conducted by sex and subsites.Results: There was no obvious correlation between total intake of solanaceous plants and CRC risk. The adjusted OR for the highest quartile and the lowest quartile was 1 (95% CI: 0.68–1.5). Certain types of solanaceous vegetables were negatively associated with the risk of CRC, such as eggplant (OR = 0.42; 95% CI:0.29–0.62) and sweet pepper (OR = 0.48; 95%CI: 0.33–0.7). Potato was found to have a positive correlation with CRC (OR = 1.76; 95% CI: 1.26–2.47). In the stratified analyses by gender, total solanaceous vegetables intake was inversely associated with CRC risk only in men. In the stratified analyses of cancer subsites, no significant association between total solanaceous vegetables intake and CRC risk was found.Conclusion: No findings showed that the intake of total solanaceous vegetables was related to the reduction of CRC risk. However, specific types of solanaceous vegetables indicated an inverse association with CRC risk.

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“…18 These cells are non-invasive, poorly aggressive and have low metastatic potential. 19,20 Vanilla plant was known for many medicinal properties but its anti-cancerous properties were little known till date. Many phytochemicals were identified in this plant that possess various biological activities.…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative effects of Vanilla planifolia leaf extract against breast cancer MCF-7 cells

Kaliappan¹,

Punnagai²

2018

Int J Basic Clin Pharmacol

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Background: Breast cancer is the most common cancer disease among females in India and worldwide. This needs a critical research for finding the drugs to treat breast cancer with less side effects. The aim of the present study is to reveal the anti-proliferative effects of vanilla extract against MCF-7 cells.Methods: To reveal anti proliferative effects of vanilla leaf extract, MTT assay, cell cycle analysis and DNA fragmentation assay was performed as per standard protocols.Results: MTT assay showed decrease in cell viability with increase of dose of extract and revealed IC50 value at 31.2µg/ml. DNA fragmentation was seen in extract treated cells.Conclusions: The results of the present study confirm the antiproliferative property of vanilla leaf extract in MCF-7 cells. This study results conclude vanilla leaf extract as an effective plant source medicament for treating breast cancer.

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Antineoplastic effect of pectic polysaccharides from green sweet pepper (Capsicum annuum) on mammary tumor cells in vivo and in vitro

Cited by 34 publications

References 46 publications

Efeitos De Polissacarídeos Do Jambo No Modelo Tumoral Solido De Ehrlich Em Camundongos

Efeitos De Polissacarídeos Do Jambo No Modelo Tumoral Solido De Ehrlich Em Camundongos

Solanaceous Vegetables and Colorectal Cancer Risk: A Hospital-Based Matched Case-Control Study in Northeast China

Antiproliferative effects of Vanilla planifolia leaf extract against breast cancer MCF-7 cells

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