Antinociceptive Activity of an Ethanol Extract of Justicia spicigera

Abstract

Preclinical Research The aim of the present study was to evaluate the antinociceptive and sedative activity of an ethanol extract of Justicia spicigera an evergreen used in Mexican traditional medicine for the relief of pain, wounds, fever and inflammation. At 200 mg/kg po, the maximum dose examined, the ethanol extract of J. spicigera (JSE) had analgesic activity in mice in the acetic acid writhing test, the second phase of the formalin test and the tail flick test that was similar in efficacy to the NSAID, naproxen (150 mg/kg po). JSE was inactive in the hot plate test and and the ketamine-induced sleeping time test; it had no sedative effects. These results show that the ethanol extract from the leaves of J. spicigera has antinociceptive effects in mice without inducing sedation. Drug Dev Res 77 : 180-186, 2016. © 2016 Wiley Periodicals, Inc.

Optimization of ultrasonic-assisted extraction of phenolic compounds from Justicia spicigera leaves

“…The estimated effects of each variable as well as their interactions on the extracted soluble phenols are listed in Table 2. Also, according to the regression model, the soluble phenolic content from J. spicigera leaf extracts using ultrasonic-assisted extraction can be predicted with the following polynomial equation [3] (R 2 = 0.97, R 2 Adj. = 0.96 with 99% confidence level):…”

“…Fresh J. spicigera (J. spicigera) leaves have a bright green color, but aqueous extracts from J. spicigera leaves produce a deep purple-reddish hue due to the release of colored compounds [2]. Infusions from J. spicigera leaves had been used in Mexico for people suffering from dengue considering [3]. Justicia spicigera leaves are considered to be useful in treatment of diabetes, as antihypertensive as antipyretics, and antitumoral [4][5][6].…”

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

“…In the same way, the antidiabetic, [ 168 ] antitumor, immunomodulatory [ 169 ], anti-inflammatory [ 136 ] and antiparasitic [ 170 ] properties of this plant have been demonstrated. Pertaining to the topic of this review, J. spicigera has reduced nociception in several inflammatory pain models [ 171 ], suggesting that its antinociceptive effect can be attributed to kaempferitrin ( Figure 1 ), which in turn induces antispasmodic effects through the activation of 5-HT 1A and opioid receptors [ 172 , 173 ]. As a recapitulation, the pharmacological studies support the ancient use of J. spicigera to alleviate painful conditions.…”

Microencapsulates by spray of Lacticaseibacillus rhamnosus GG from fermented whole or skimmed cow's milk added with Mexican honeysuckle (Justicia spicigera) extract using mesquite gum as carrier agent

“…The J. spicigera plant is native to Mexico and has been used for dyeing fabrics ( Baqueiro-Peña and Guerrero-Beltrán, 2017 ; Chan-Bacab et al., 2015 ), make paintings, codices, murals ( Arberet et al., 2021 ; Casanova-González et al., 2012 ), painting crafts ( Baqueiro-Peña and Guerrero-Beltrán, 2017 ), and coloring tortillas (traditional Mexican corn flat bread) ( Alvarez-Poblano et al., 2020 ). In addition, it has been used in traditional medicine as an anxiolytic ( García-Ríos et al., 2019 ), anti-inflammatory ( Real-Sandoval et al., 2020 ), analgesic ( Zapata-Morales et al., 2016 ), antipyretic ( Baqueiro -Peña and Guerrero-Beltrán, 2014 ), among others. Its efficacy as an antimicrobial against pathogenic bacteria and fungi ( Bernardo-Mazariegos et al., 2019 ; Jacobo-Salcedo et al., 2011 ) and against cancer cells ( Jacobo-Salcedo et al., 2011 ) has also been reported.…”