Antinociceptive and anti-Inflammatory effects of the standardized oil of Indian <i>Callistemon lanceolatus</i> leaves in experimental animals

Abstract

The effect of CaUistemon lanceolatus (Syn. C. citrinus curtis; Family: Myrtaceae) leaf oil was studied for the antinociceptive and anti-inflammatory activity in experimental animals. C. lanceolatus, 25-100 mgkg administered orally for 3 days exhibited graded dose response equivalent to 21.95%-89.90% protection in the tail flick latent test in rat. The C. lanceolatus oil (50 and 100 mgkg, given orally for 3 days) was effective in hot plate reaction time (64.05% and 112.97%, p< 0.01 and p< 0.001), analgesymeter induced mechanical pain (28.17% and 54.42%, p C 0.01 and p C 0.001) and acetic acid-induced writhing (26.68% and 51.79%, p < 0.5 and p < 0.05) in mice. The oil of C. lanceolatus potentiated the analgesic activity with pentazocine (10 mgkg, i.p.) and aspirin (25 mgkg, i.p.). In the carrageenan-induced paw edema C. lanceolatus oil (50 and 100 mglkg, given orally for 3 days) decreased paw volume significantly (26.68% and 51.79%) and dose dependent anti-inflammatory activity in 1-3 hour time interval and potentiated with nimesulide (50 mgkg, p.0.). In summary, this study demonstrates that leaf oil of C. lanceolatus has significant antinociceptive and anti-inflammatory activity.

Polyphenolic constituents of the methanolic extract of Callistemon viridiflorous leaves and its antimicrobial activity

“…[6][7][8][9][10][11][12][13] Previous phytochemical investigations of some species of Callistemon genus resulted in the identification of C-methyl flavonoids, falvonol glycosides, phenolic acids, hydrolysable ellagitannins, triterpenoids and phloroglucinol derivatives. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Because of the biological importance of plant polyphenols, particularly tannins and flavonoids, a phytochemical study was of interest to investigate the constitutive poyphenols in the extract of leaves for Callistemon viridiflorous. Synonyms of the plant include Callistemon viridiflorus (Sieber ex Sims) Sweet, Callistemon salignus var.…”

Cardioprotective activity of ethanolic extract of Callistemon lanceolatus leaves on doxorubicin-induced cardiomyopathy in rats

“…It is indigenous to Australia. The Lambadi tribals of north telangana districts of Andhra Pradesh use this plant for the treatment of pain, gastrointestinal disorders and infectious diseases (Sudhakar et al, 2004). Aqueous extracts of the leaves and flowers have antifungal and antibacterial activity.…”

“…The essential oils from leaves possess antimicrobial, fungitoxic, antinociceptive and anti-inflammatory activities. Several triterpenoids, flavonoides, fatty acids, tannins and phenolic compounds have been isolated from its leaves (Sudhakar et al, 2004;Jeong et al, 2009). The leaves was also reported for its hepatoprotective effect (Jain et al, 2007), antidiabetic, hypolipidemic and anti-oxidant activity (Kumar et al, 2011).…”

Pharmacognostic study and anti–inflammatory activity of Callistemon lanceolatus leaf

“…The essential oils from leaves possess antimicrobial, fungitoxic, antinociceptive and anti-inflammatory activities. Several triterpenoids, flavonoids, fatty acids, tannins, and phenolic compounds have been isolated from its leaves [6,7] . The present work was undertaken to study pharmacognostic characteristics and anti-inflammatory activity of C. lanceolatus.…”