Antinociceptive and anti-inflammatory effects of Caryocar coriaceum Wittm fruit pulp fixed ethyl acetate extract on zymosan-induced arthritis in rats

Bioactive compounds and functional potential of pequi (<em>Caryocar</em> spp.), a native Brazilian fruit: a review

“…This oil exhibited a similar profile of topical antiinflammatory activity as the drugs that classically modulate the production of AA metabolites and significantly reduced or inhibited the edema when compared to the control group. Consistent with these results, De Oliveira et al (2015) found that C. coriaceum pulp oil had anti-nociceptive and anti-inflammatory effects in a model of acute arthritis induced by zymosan in rat knees, suggesting its possible application in the treatment of inflammatory joint diseases.…”

“…They also increase fat oxidation and fecal output and inhibit HMG-CoA reductase or activate LPL, contributing to the improvement of the lipid and the cardiovascular profiles. Its effects also cover an improvement in the antioxidant defense system due to the phytochemicals present in the fruit, increasing the activities and expression of antioxidant enzymes and reducing oxidative stress (Yamaguchi et al, 2017;De Oliveira et al, 2015;Miranda-Vilela et al, 2014;Almeida et al, 2012;Miranda-Vilela et al, 2011;Saraiva et al, 2011b;De Oliveira et al, 2010;Da Silva Quirino et al, 2009).…”

“…The exact mechanism of anti-inflammatory action is still subject of debate; however, these effects may correlate with the properties of carotenoids and FA, such as oleic acid, present in the Caryocar spp., probably by reducing the concentration and expression of inflammatory mediators at protein and genomic levels via the production of anti-inflammatory eicosanoids, inhibition of cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, or by the improvement of the antioxidant defense system (Yamaguchi et al, 2017;Torres et al, 2016a;De Oliveira et al, 2015;Saraiva et al, 2011b;De Oliveira et al, 2010;Miranda-Vilela et al, 2009b;Da Silva Quirino et al, 2009). …”

The Antinociceptive Effect of the Leaves and Flowers Ethanolic Extracts of Tabebuia aurea (Silva Manso) Benth & Hook. F. ex S. Moore

“…Steroidal and non-steroidal anti-inflammatory drugs are used in conventional treatments, as well as drugs that alter the course of the disease such as: cyclosporin, chloroquine, amongst others. The long-term use of these drugs can cause hepatic and gastrointestinal disorders, which encourages the search on new treatments 4 . The study of medicinal plants has become a strategy in the search of pharmacological alternatives due to their ethnopharmacological use.…”

Estudo do efeito imunomodulador do derivado 3-fenilcumarínico 6,7-diidroxi-3-[3&#39;,4&#39;-metilenodioxifenil]-cumarina em neutrófilos humanos estimulados e em modelo animal de inflamação induzida por zimosan

“…Dentre os modelos animais de artrite, o modelo de indução de inflamação articular induzida por zimosan tem sido também utilizado para avaliar o efeito anti-inflamatório de produtos naturais (Penido et al, 2006;Paiva et al, 2011;Yamada et al, 2013). Também nesses estudos, as substâncias naturais foram utilizadas de forma livre e com altas dosagens (Nonose et al, 2014;Bezerra De Oliveira et al, 2015). No entanto, o uso de lipossomas em investigações desta natureza, tem sido empregados, sendo na grande maioria incorporando enzimas antioxidantes, como a superóxido dismutase (SOD) (Van Den Hoven et al, 2011;Kapoor et al, 2014).…”