Antinociceptive and Anti-inflammatory Properties of &lt;i&gt;Corchorus capsularis&lt;/i&gt; Leaves Chloroform Extract in Experimental Animal Models

Zakaria, Zainul Amiruddin; Sulaiman, Mohd Roslan; Gopalan, Hanan Kumar; Ghani, Zuleen Delina Fasya Abdul; Nor, Raden Nur Suraya Raden Mohd.; Jais, Abdul Manan Mat; Abdullah, Fatimah Corazon

doi:10.1248/yakushi.127.359

Cited by 18 publications

(20 citation statements)

References 24 publications

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“…The method described by Zakaria et al [9] was adopted in the present study. Rats were placed in the observation chamber to familiarize them with their surroundings for an initial 20 min of accommodation.…”

Section: Antinociceptive Assaysmentioning

confidence: 99%

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In vivo Antinociceptive and Anti-inflammatory Activities of Dried and Fermented Processed Virgin Coconut Oil

et al. 2011

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Objective: The present study was carried out to investigate the antinociceptive and anti-inflammatory activities of virgin coconut oil (VCO) produced by theMalaysian Agriculture Research and Development Institute (MARDI) using various in vivo models. Materials and Methods: Two types of VCOs, produced via standard drying (VCOA) and fermentation (VCOB) processes were used in this study. Both VCOA and VCOB were serially diluted using 1% Tween 80 to concentrations (v/v) of 10, 50 and 100%. Antinociceptive and anti- inflammatory activities of both VCOs were examined using various in vivomodel systems. The antinociceptive activity of the VCOs were compared to those of 1% Tween 80 (used as a negative control), morphine (5 mg/kg) and/or acetylsalicylic acid (100 mg/kg). Results: Both VCOA and VCOB exhibited significant (p < 0.05) dose-dependent antinociceptive activity in the acetic acid-induced writhing test. Both VCOs also exerted significant (p < 0.05) antinociceptive activity in both phases of the formalin and hot-plate tests. Interestingly, the VCOs exhibited anti-inflammatory activity in an acute (carrageenan-induced paw edema test), but not in a chronic (cotton-pellet-induced granuloma test) model of inflammation. Conclusion: The MARDI-produced VCOs possessed antinociceptive and anti-inflammatory activities. Further studies are needed to confirm these observations.

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Section: Antinociceptive Assaysmentioning

confidence: 99%

“…The procedure described by Zakaria et al [10] was used to determine the anti-inflammatory activity of VCOs in this model of acute inflammation. Rats were divided into 5 groups (n = 7) and received (p.o.)…”

Section: Antinociceptive Assaysmentioning

confidence: 99%

In vivo Antinociceptive and Anti-inflammatory Activities of Dried and Fermented Processed Virgin Coconut Oil

et al. 2011

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“…The test produced a distinct biphasic nociceptive response generally regarded as the early (first) and late (second) phases. The early phase is result of direct stimulation of nociceptors by formalin and is an acute reaction observed immediately after the administration of the agent (0-5 min, tonic pain) (Zakaria et al, 2007). This phase is produced from stimulation of myelinated and unmyelinated fibers, mainly C fibers, and the release of substance P, histamine, CGRP and can be suppressed by opioid analgesic drugs like morphine.…”

Section: Discussionmentioning

confidence: 99%

“…Histamine appears to be the principal mediator in this phase (Wang et al, 2008). The second phase (15-30 min, localized inflammatory pain) is due to the inflammatory processes, with mediators release locally, such as prostaglandins, serotonin, histamine and bradykinin, as well as activation of the neurons located in the dorsal horns, which promote facilitation of synaptic transmission at the spinal cords Zakaria et al, 2007). This latter phase was reported to be sensitive to the action of the majority of NSAID, including acetil salicilic acid, indomethacin or naproxen (Gonçalves et al, 2008) consequently the inhibition of the second phase suggest anti-inflammatory mechanism, although analgesics without anti-inflammatory properties such fentanyl, may exhibit this effect.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju

Vanderlinde¹,

Rocha²,

Malvar³

et al. 2012

Rev. bras. farmacogn.

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Mikania lindleyana DC., Asteraceae (sucuriju), grows in the Amazon region, where is frequently used to treat pain, inflammatory diseases and scarring. This study was carried out to investigate phytochemical profile accompanied by in vivo antinociceptive and anti-inflammatory screening of n-hexane (HE), dichloromethane (DME) and methanol (ME) extracts obtained from the aerial parts of the plant. The oral administration of ME (0.1, 0.3, 1 g/kg) caused a dose-related reduction (16.2, 42.1 e 70.2%) of acetic acid-induced abdominal writhing while HE and DME (1 g/kg, p.o.) were ineffective. In the hot plate test, ME (300 mg/kg, p.o.) increased the latency of heat stimulus between 30 and 120 min and inhibited the first (45%) and second (60%) phases of nociception in the formalin test. The antinociception induced by ME or positive control fentanyl (150 µg/kg, s.c.) in hot plate and formalin tests was prevented by naloxone (3 mg/kg, s.c.). When submitted to the carrageenan-induced peritonitis test, ME (0.5, 1.0, 2.0 g/kg, p.o.) impaired leukocyte migration into the peritoneal cavity by 46.8, 59.4 and 64.8% respectively, while positive control dexamethasone (2 mg/kg, s.c.), inhibited leukocyte migration by 71.1%. These results indicate that the antinociception obtained after oral administration of methanol extract of M. lindleyana involves anti-inflammatory mechanisms accompanied with opioid-like activity which could explain the use of the specie for pain and inflammatory diseases.

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“…Additionally, a decoction of the roots, as well as unripe fruits, has long been used to combat dysentery. The leaves of C. capsularis are actually consumed as vegetables in numerous area of the world such as Bangladesh, Africa, Middle East and Southeast Parts of Asia, which include Malaysia, for a long period (Zakaria et al, 2007). In the present study, phytochemical and antimicrobial investigations of different fractions of the methanolic extract of C. capsularis leaf were screened.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and antimicrobial investigations of different fractions of the methanolic extract of Corchorus capsularis leaves

Mondal¹,

Sohel²,

Kawsar³

et al. 2017

Afr. J. Pharm. Pharmacol.

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The purpose of this study was to understand and investigate the phytochemical and antimicrobial effects of different fractions of the methanolic extract of Corchorus capsularis leaf. For the extraction of lipophilic compounds with the help of methanol solvent system, cold extraction process was used, where the grinded coarse powder of the leaf was soaked in methanol and kept for four days for proper extraction. After that, the extract was concentrated by using rotatory evaporator and dried in room temperature. Compounds in the extract were separated according to their polarity by using vacuum liquid chromatography (VLC) and solvents of different polarity N-hexane, benzene, diethyl ether, chloroform, dichloromethane. Later, thin layer chromatography (TLC), flavonoid assay, disk diffusion, inhibitory action in nutrient broth was done for different fractions of the methanolic extract. Diethyl ether, chloroform, dichloromethane fractions showed good anti-oxidant property but poor antibacterial activity against different types of microorganism. Chloroform fraction showed good inhibitory activity against Aspergilus niger (fungus) in nutrient broth.

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Antinociceptive and Anti-inflammatory Properties of <i>Corchorus capsularis</i> Leaves Chloroform Extract in Experimental Animal Models

Cited by 18 publications

References 24 publications

In vivo Antinociceptive and Anti-inflammatory Activities of Dried and Fermented Processed Virgin Coconut Oil

In vivo Antinociceptive and Anti-inflammatory Activities of Dried and Fermented Processed Virgin Coconut Oil

Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju

Phytochemical and antimicrobial investigations of different fractions of the methanolic extract of Corchorus capsularis leaves

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