Antiobesity effect of Stellaria media against drug induced obesity in Swiss albino mice

Abstract

The whole plant of Stellaria media (family: Caryophyllaceae) has been tested for its antiobesity activity by using progesterone-induced obesity model in female albino mice. The effect of S. media on food consumption pattern, change in body weight, thermogenesis, lipid metabolism, and histology of fat pad. were examined. Methanolic and alcoholic extracts of the S. media were used in the study. Methanolic extract of S. media (MESM) have prevented the increase in body weight, adipose tissue weight and size, and upturned obesity and associated complications. MESM has also shown promising effects compared with alcoholic extract of S. media may be because of its multiple mechanisms. These findings suggest that antiobesity activity produced by MESM is because of its anorexic property mediated by saponin and flavonoid and partly of by its β-sitosterol content. β-Sitosterol in the plant extract was confirmed by thin-layer chromatography study. β-sitosterol is plant sterol having structural similarity with dietary fat which do the physical competition in the gastrointestinal tract and reduces fat absorption. Before carrying in vivo activity detail pharmacognostic and phytochemical analysis of the extracts was carried out. The plant has shown the presence of saponin, flavonoids, steroids and triterpenoids, glycosides, and anthocynidine. By this study, it can be concluded that, MESM is beneficial in suppression of obesity induced by progesterone.

Impact of Anthocleista vogelii root bark ethanolic extract on weight reduction in high carbohydrate diet induced obesity in male wistar rats

“…However, A. vogelii caused significant decrease in food intake and body weight in HCD induced obese rats during the treatment period. The reduction in the food intake in the HCD obese group treated with A. vogelii may be due to its ability to suppress the animals' appetite indicating action of bioactive components like saponin, and this was similar to the results reported by Chidrawar (2011).…”

Effect of Stellaria media Tea on Lipid Profile in Rats

“…In the literature, the antiobesity effect of Stellaria media was examined using various rodent obesity models [21][22][23].…”

Functional polarization of macrophages of rats with progesterone-induced obesity treated with melanin from the Antarctic yeast Nadsoniella nigra

“…The treatment of women with progesterone in MHT also increases the food intake, and therefore fat accumulation in the organism (Bonny et al, 2014, Coquoz et al, 2019. Similar effects were observed in rats and mice, which led to the development of the animal model of progesteroneinduced obesity (Kaur & Kulkarni, 2001, Chidrawar et al, 2011, Gundamaraju et al, 2012, Suneetha et al, 2013. However, only sparse data obtained using such model are available, and these are insufficient for an understanding of progesterone-induced obesity mechanisms.…”