Antiobesity Effects of Pulp Extract Tamarindus indica in Albino Rat

Ukwuani, A. N.; Abukakar, M. G.; Shehu, R.A.; Hassan, L.G.

doi:10.3923/ajb.2008.221.227

Cited by 9 publications

(10 citation statements)

References 11 publications

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“…[35] Research by Yerima et al, [36] showed that extract of T. indica L has effect on hypolipidemia and hypoglycemia. This result is slightly different from that reported in the study by Ukwuani et al, [37] which found that the aqueous extract of pulp of T. indica L decreases levels of total cholesterol and LDL but increases those of HDL and triglycerides. [37] Chemical constituents in 70% ethanolic extract of T. indica L fruit rind and flesh in this study were flavonoids, alkaloids, terpenoids, and phenolic.…”

Section: |Discussioncontrasting

confidence: 99%

“…This result is slightly different from that reported in the study by Ukwuani et al, [37] which found that the aqueous extract of pulp of T. indica L decreases levels of total cholesterol and LDL but increases those of HDL and triglycerides. [37] Chemical constituents in 70% ethanolic extract of T. indica L fruit rind and flesh in this study were flavonoids, alkaloids, terpenoids, and phenolic. Several other studies mentioned T. indica L contains chemical constituents such as malic acid, [18] tartaric acid, mucilage and pectin, arabinose, xylose, galactose, glucose, and uronic acid, [38][39] and phenolic compound and cardiac glycosides.…”

Section: |Discussioncontrasting

confidence: 99%

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Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats

Sutrisna¹,

Usdiana²,

Taqwin³

et al. 2015

Natl J Physiol Pharm Pharmacol

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Background: Tamarindus indica L is widely used as a traditional medicine. In Indonesia T. indica L is commonly used to treat gastritis, rheumatism, constipation, and fever. Aims and Objective: The purpose of this study was to examine the hypolipidemic effect of 70% ethanolic extract of T. indica L fruit flesh and rind and their chemical compounds. Materials and Methods: A total of 40 Wistar male rats were divided into 8 groups. group I was negative control (aquabidest); group II was positive control (Simvastatin 0.72 mg/gbw); groups III, IV, and V were treated by 70% ethanolic extract of the flesh fruit with doses of 200, 100, and 50 mg/kgbw, respectively; groups VI, VII, and VIII were treated by 70% ethanolic extract of the rind fruit with doses of 200, 100, and 50 mg/kgbw, respectively. The extract was given for 7 days after the third day. Measurement of plasma total cholesterol and triglyceride were carried out on days 0, 3, and 10. Result: The results show that the 70% ethanolic extract of T. indica L fruit rind and flesh with doses of 200, 100, and 50 mg/kgbw can reduce plasma total cholesterol and triglyceride significantly (P o 0.01). Chemical content of 70% ethanolic extract of T. indica L fruit rind and flesh by thin-layer chromatography examination are alkaloids, flavonoids, terpenoids, and phenolic. Conclusion: The 70% ethanolic extract of T. indica L fruit flesh and rind exert effect for lowering total cholesterol and triglyceride on hyperlipidemia induced by Triton X-100 in Wistar rats.

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Section: |Discussioncontrasting

confidence: 99%

Section: |Discussioncontrasting

confidence: 99%

Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats

Sutrisna¹,

Usdiana²,

Taqwin³

et al. 2015

Natl J Physiol Pharm Pharmacol

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“…Food intake was estimated by subtracting the amount of food left in the cages from the total amount of food provided to each rat. Measured on day 1 & then on alternate day for 42 days in each group [27]. Blood was collected from the retro-orbital plexus of the all groups of overnight fasted rats using microcapillary tubes containing heparin on 43 th day.…”

Section: Animal Experimentsmentioning

confidence: 99%

Anti-Obesity Effect of Arq Zeera and Its Main Components Thymol and Cuminaldehyde in High Fat Diet Induced Obese Rats

Haque

Ansari

2018

Drug Res (Stuttg)

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Arq zeera is a distillate product that prepared from four different herbs namely Trachyspermum ammi L., apiaceae, Zingiber officinale Roxb., zingiberaceae, Carum carvi L.,apiaceae and Cuminum cyminum L., apiaceae. The present study aims to determine the antiobesity effect of arq zeera and its main components thymol and cuminaldehyde in high fat diet induced obese rats and to explore its mechanism of action. In current study, orlistat was used as positive controls. Male Wistar rats were fed with HFD for 42 days to induce obesity. HFD-fed rats were administered with arq zeera, thymol, cumic aldehyde, thymol + cuminaldehyde and orlistat for 28 days. During the course of treatment, body weight and food intake frequently observed and after end of treatments, liver weight, visceral fat pad weight, plasma lipid proflie, alanine aminotransferase, aspartate aminotransferase, glucose, insulin, leptin levels and pancreatic lipase activity were studied on all treated obese rats. The histopathology of liver was also studied. After the treatments of arq zeera and its main components, body weight, food intake, liver weight, visceral fat pad weight and the level of lipid profile, alanine aminotransferase, aspartate aminotranferase, glucose, insulin, and leptin were found to be decreased and pancreatic lipase inhibition were increased. Arq zeera showed more potential antiobesity effect than orlistat. According to our present findings, arq zeera and its main components possessed potent antiobesity effect on high fat diet -induced obese rats and excreted anti-obesity effect partly via hypolipidemic, hypoglycemic, hypoinsulinemic, hypoleptinemic and pancreatic lipase inhibition action.

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“…The leaves and flowers of T. indica are also used as poultices for treatment of boils, swollen joints and sprains [5] . Previous pharmacological studies have shown the beneficial effects of T. indica , which include antioxidant [6] and antiobesity [3] properties. The extracts of the stem, bark and leaves of T. indica have been shown to possess broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria [4,7] .…”

Section: Introductionmentioning

confidence: 99%

“…It is also used for seasoning, and as a component in snacks and juices. In addition, juice prepared by squeezing the pulp into warm water is consumed to relieve sore throat [2,3] . In traditional African medicine, T. indica is also used for the treatment of cold, fever, stomach disorders, diarrhea, jaundice and as a skin cleanser [4] , while in ayurvedic medicine, the plant is used in the management of gastric ulcers, inflammation and digestion prob-lems.…”

Section: Introductionmentioning

confidence: 99%

In vivo Analgesic Effect of Aqueous Extract of Tamarindus indica L. Fruits

et al. 2010

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Objective: To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models. Methods: The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests. Results: The extract (60–600 mg/kg) significantly (p < 0.05) inhibited the writhing test in a dose-dependent manner with the percentage of analgesia recorded between 51.8 and 74.1%. In addition, the extract also significantly (p < 0.05) increased the latency time in the hot plate test in a dose-dependent manner. Further study showed that the extract elicited inhibitory activity in both the early and late phases of the formalin test. Moreover, pretreatment with 5 mg/kg naloxone, a nonselective opioid receptor antagonist, significantly (p < 0.05) modified the antinociceptive effect of the extract in all tests. Conclusion: The aqueous extract of T. indica possesses potential antinociceptive activity at both the peripheral and central levels, which are mediated via activation of the opioidergic mechanism.

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Antiobesity Effects of Pulp Extract Tamarindus indica in Albino Rat

Cited by 9 publications

References 11 publications

Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats

Hypolipidemic effect of Tamarindus indica L fruit on Triton X-100-induced hyperlipidemia in Wistar rats

Anti-Obesity Effect of Arq Zeera and Its Main Components Thymol and Cuminaldehyde in High Fat Diet Induced Obese Rats

In vivo Analgesic Effect of Aqueous Extract of <i>Tamarindus indica</i> L. Fruits

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