In vivo Analgesic Effect of Aqueous Extract of &lt;i&gt;Tamarindus indica&lt;/i&gt; L. Fruits

Khalid, Syamimi; Mossadeq, Wan Mastura Shaik; Israf, Daud Ahmad; Hashim, Puziah; Rejab, Sarifah; Shaberi, A.M.; Mohamad, Azam Shah; Zunita, Z.; Sulaiman, Mohd Roslan

doi:10.1159/000312710

Cited by 24 publications

(15 citation statements)

References 46 publications

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“…Over the past several years, a number of medicinal plants have been investigated for their possible anti-inflammatory and antinociceptive activities [1,2,3,4,5,6]. One of them is Satureja hortensis L. (summer savory) [2] which belongs to the Lamiaceae family and is a well-known medicinal herb in Iran.…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and Anti-Inflammatory Activities of <i>Satureja hortensis</i> Seed Essential Oil, Hydroalcoholic and Polyphenolic Extracts in Animal Models

2011

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Objective: The aim of this study was to evaluate the anti-inflammatory and analgesic effects of Satureja hortensis seed extracts and to analyze their essential oil constituents. Materials and Methods: Hydroalcoholic and polyphenolic extracts and essential oil of S. hortensis seeds were prepared using standard methods. Analgesic activity was assessed in male mice (25-35 g) using standard methods (acetic acid and formalin tests). For the evaluation of anti-inflammatory activity, the carrageenan-induced rat paw edema test was used. The mice were pretreated with 50, 100 or 200 mg/kg, i.p., hydroalcoholic or polyphenolic extracts or 100 or 200 µl/kg, p.o. Results: Hydrodistillation of the seeds of S. hortensis afforded a pale yellowish oil in a yield of 0.05% (v/w). Pretreatment of mice with hydroalcoholic or polyphenolic extracts or essential oil significantly (p < 0.001) reduced acetic acid-induced abdominal twitches. Hydroalcoholic extracts also significantly reduced pain responses in early and late phases of the formalin test whereas the polyphenolic extract and essential oil were only effective in the late phase of the formalin test. All three fractions were found to reduce paw edema in the carrageenan test. Conclusion: These results clearly demonstrate the analgesic and anti-inflammatory activity of S. hortensis seeds and since the hydroalcoholic extract relieved pain in the first phase of the formalin test, it seems that at least part of its analgesic activity may be mediated centrally. The results of this study substantiated the traditional use of S. hortensis plant seeds in painful and inflammatory ailments.

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Section: Introductionmentioning

confidence: 99%

Antinociceptive and Anti-Inflammatory Activities of <i>Satureja hortensis</i> Seed Essential Oil, Hydroalcoholic and Polyphenolic Extracts in Animal Models

2011

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“…Seeds of the plant have antidiabetic,[3] antisnake venom,[4] hepatoregenerative[5] properties. Pulp of fruits have hypolipidemic, antioxidant,[6] antifluorosis,[7] and analgesic,[8] hepatoregenerative,[5] and spasmolytic[9] activities. Its leaves have antiemetic,[10] antibacterial,[11] and hepatoregenerative[5] activities.…”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic and weight reducing activity of the ethanolic extract of Tamarindus indica fruit pulp in cafeteria diet- and sulpiride-induced obese rats

Vaneeta¹,

Dinesh²,

Sharma³

et al. 2011

Journal of Pharmacology and Pharmacotherapeutics

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Objectives:To investigate the effect of ethanolic extract of fruit pulp of Tamarindus indica Linn. (Family: Caesalpiniaceae) on obesity in rats using cafeteria diet-induced obesity and antipsychotic drug (sulpiride)-induced obesity.Materials and Methods:Cafeteria dietwas administered for 40 successive days to male Wistar rats and sulpiride (20 mg/kg, i.p.) was administered for 28 successive days to female Wistar rats. In separate groups of animals, the ethanolic extract (50 and 100 mg/kg p.o.) of Tamarindus indica fruit was administered along with cafeteria diet for 40 successive days to Wistar male rats and along with sulpiride for 28 successive days to Wistar female rats.Results:Cafeteria diet alone significantly increased body weight, serum total cholesterol, triglycerides, and glucose levels and decreased HDL cholesterol in male rats as compared to control. Sulpiride per se significantly increased the levels of glucose, triglycerides, cholesterol and there was no significant effect on HDL-cholesterol in female rats as compared to control. Ethanolic extract showed a significant decrease in body weight, serum cholesterol, and triglycerides and a significant increase in HDL-cholesterol in cafeteria diet- and sulpiride-induced obese rats as compared to their respective control groups.Conclusions:Thus, the ethanolic extract of Tamarindus indica fruit pulp showed a significant weight-reducing and hypolipidemic activity in cafeteria diet- and sulpiride-induced obese rats.

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“…This finding confirmed the previous report [12] that THME showed anti-inflammatory activity in 2 models of acute inflammation in mice, so the antinociceptive effect seen could have been due in part to inhibition of the release of inflammatory mediators or blockade of the peripheral cyclooxygenase activity. It is probable that the pain associated with this assay could be generated indirectly via stimulation of the peripheral nociceptive neurons by endogenous mediators like serotonin, histamine, bradykinin, and prostaglandins [20] . However, this chemical method has good sensitivity but poor specificity, allowing misinterpretation of the results, because this is an unspecific stimulus for nociception, sensitive to drugs with different mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive Activity of Methanol Extract of Tabebuia hypoleuca (C. Wright ex Sauvalle) Urb. Stems

Regalado

Mancebo

Paixão³

et al. 2017

Med Princ Pract

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than in the control group. In the formalin test, the licking time for THME at doses of 300 and 500 mg/kg was significantly shorter ( p < 0.001) compared to the control group in the first phase of the formalin test, whereas in the second phase only the dose of 500 mg/kg showed an antinociceptive effect. In addition, THME at doses of 300 and 500 mg/kg significantly increased the latency time in the tail flick test ( p < 0.05 and p < 0.001, respectively) and in the hot plate test ( p < 0.01 and p < 0.001, respectively) compared to the control group. Conclusions: These results show that THME had antinociceptive activity using several models of nociception, and they suggest that the effect is mediated by the participation of both peripheral and central antinociceptive mechanisms. AbstractObjective: The aim of this study was to evaluate the antinociceptive activity of the methanol extract of Tabebuia hypoleuca stems (THME). Materials and Methods: The animals were divided into 5 groups of 8 mice for each test (negative controls, positive controls, and 3 groups treated with THME at doses of 150, 300, and 500 mg/kg, p.o.). The antinociceptive effect of THME was evaluated using the writhing, formalin, tail flick, and hot plate models in mice. Results: In the writhing test, THME (150, 300, and 500 mg/kg) produced significantly ( p < 0.001) fewer writhes induced by acetic acid Significance of the Study• In this study Tabebuia hypoleuca was shown to have antinociceptive effects mediated by the participation of both peripheral and central antinociceptive mechanisms. The T. hypoleuca species could become a new therapeutic option for the treatment of pain.

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In vivo Analgesic Effect of Aqueous Extract of <i>Tamarindus indica</i> L. Fruits

Cited by 24 publications

References 46 publications

Antinociceptive and Anti-Inflammatory Activities of <i>Satureja hortensis</i> Seed Essential Oil, Hydroalcoholic and Polyphenolic Extracts in Animal Models

Antinociceptive and Anti-Inflammatory Activities of <i>Satureja hortensis</i> Seed Essential Oil, Hydroalcoholic and Polyphenolic Extracts in Animal Models

Hypolipidemic and weight reducing activity of the ethanolic extract of Tamarindus indica fruit pulp in cafeteria diet- and sulpiride-induced obese rats

Antinociceptive Activity of Methanol Extract of Tabebuia hypoleuca (C. Wright ex Sauvalle) Urb. Stems

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