Hypolipidemic and weight reducing activity of the ethanolic extract of Tamarindus indica fruit pulp in cafeteria diet- and sulpiride-induced obese rats

Abstract

Objectives:To investigate the effect of ethanolic extract of fruit pulp of Tamarindus indica Linn. (Family: Caesalpiniaceae) on obesity in rats using cafeteria diet-induced obesity and antipsychotic drug (sulpiride)-induced obesity.Materials and Methods:Cafeteria dietwas administered for 40 successive days to male Wistar rats and sulpiride (20 mg/kg, i.p.) was administered for 28 successive days to female Wistar rats. In separate groups of animals, the ethanolic extract (50 and 100 mg/kg p.o.) of Tamarindus indica fruit was administered along with cafeteria diet for 40 successive days to Wistar male rats and along with sulpiride for 28 successive days to Wistar female rats.Results:Cafeteria diet alone significantly increased body weight, serum total cholesterol, triglycerides, and glucose levels and decreased HDL cholesterol in male rats as compared to control. Sulpiride per se significantly increased the levels of glucose, triglycerides, cholesterol and there was no significant effect on HDL-cholesterol in female rats as compared to control. Ethanolic extract showed a significant decrease in body weight, serum cholesterol, and triglycerides and a significant increase in HDL-cholesterol in cafeteria diet- and sulpiride-induced obese rats as compared to their respective control groups.Conclusions:Thus, the ethanolic extract of Tamarindus indica fruit pulp showed a significant weight-reducing and hypolipidemic activity in cafeteria diet- and sulpiride-induced obese rats.

Antioxidant-rich Tamarindus indica L. leaf extract reduced high-fat diet-induced obesity in rat through modulation of gene expression

“…Our findings were in agreement with another report where the extract of T. indica seeds was shown to have potent plasma lipid and glucose-lowering activities in streptozotocin-induced diabetic rats [10]. However, our observations were slightly different from another report where T. indica aqueous pulp extract considerably reduced serum cholesterol, body weight, and LDL-C but increased HDL-C and triglycerides in normal chow diet-fed healthy rats [42].…”

Influence of extracting solvent on pharmacological activity and cytotoxicity of Polygonum minus, a commonly consumed herb in Southeast Asia

“…Commonly available plants such as Camellia sinensis , Tamarindus indica , and Garcinia atroviridis showed potential antihyperlipidemic activity in animal models. [ 10 11 12 ] In addition, medicinal plants and their derived products such as garlic, fenugreek, and curcumin were found to be effective in lowering cholesterol in human trials. [ 13 14 ] The excellent antioxidant capacity of many natural products is of advantage, in particular to prevent lipids peroxidation.…”

Anti-obesity activity of chloroform-methanol extract of Premna integrifolia in mice fed with cafeteria diet

“…[78] Nearly one third of the world's adult population (1.3 billion people) was overweight or obese in 2005 and if recent trends continue, by 2030 nearly two third of the world's adult population (3.3 billion people) could be either overweight or obese. [9] Moreover, obese and overweight patients are at higher risk from coronary artery disease, hypertension, hyperlipidemia, diabetes mellitus, cancers, gall bladder disorders, cerebrovascular accidents, osteoarthritis, restrictive pulmonary disease and sleep apnea. [1011] Recently, much attention has been focused on some food factors/natural compounds that may be beneficial in preventing high fat diet induced body fat accumulation and possibly reduce the risk of diabetes and heart disease.…”