Antioxidant Activities and Polyphenolic Contents of Three Selected Micromeria Species from Croatia

Vladimir‐Knežević, Sanda; Blažeković, Biljana; Štefan, Maja Bival; Alegro, Antun; Kőszegi, Tamás; Petrik, József

doi:10.3390/molecules16021454

Cited by 131 publications

(94 citation statements)

References 38 publications

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“…Therefore, the ability of a compound to transfer electron is a significant indicator of its potential as an antioxidant [27] . This indicates that the antioxidant compounds are electron donors and could reduce the oxidized intermediate of lipid peroxidation processes; thus acting as primary and secondary antioxidants [28] . These findings verify the efficiency of the different parts extracts of T. hirsuta against the ABTS radical cation, DPPH radical as well as in FRAP assay.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical screening and antioxidant capacity of the aerial parts of Thymelaea hirsuta L.

Amari

Bouzouina

Berkani

et al. 2014

Asian Pacific Journal of Tropical Disease

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Section: Discussionmentioning

confidence: 99%

Phytochemical screening and antioxidant capacity of the aerial parts of Thymelaea hirsuta L.

Amari

Bouzouina

Berkani

et al. 2014

Asian Pacific Journal of Tropical Disease

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“…The reducing power of the samples was determined by the method of Oyaizu [15] , as described previously [16] . Briefly, an aliquot of the sample (1.0 mL) at various concentrations (1.25-100 μg/mL) was mixed with phosphate buffer (0.2 mol/L, pH 6.6, 2.5 mL) and 1% potassium ferricyanide (2.5 mL).…”

Section: Reducing Power Assaymentioning

confidence: 99%

“…The total antioxidant capacity of rutin and quercetin was evaluated by the phosphomolybdenum method according to the procedure of Prieto et al [19] , as described previously [16] . Briefly, the sample was dissolved in ethanol, and an aliquot of the solution (0.3 mL) was combined in a vial with the reagent …”

Section: Total Antioxidant Capacity Assaymentioning

confidence: 99%

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

et al. 2012

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Aim: To investigate the mechanisms underlying the protective effects of quercetin-rutinoside (rutin) and its aglycone quercetin against CCl 4 -induced liver damage in mice. Methods: BALB/cN mice were intraperitoneally administered rutin (10, 50, and 150 mg/kg) or quercetin (50 mg/kg) once daily for 5 consecutive days, followed by the intraperitoneal injection of CCl 4 in olive oil (2 mL/kg, 10% v/v). The animals were sacrificed 24 h later. Blood was collected for measuring the activities of ALT and AST, and the liver was excised for assessing Cu/Zn superoxide dismutase (SOD) activity, GSH and protein concentrations and also for immunoblotting. Portions of the livers were used for histology and immunohistochemistry. Results: Pretreatment with rutin and, to a lesser extent, with quercetin significantly reduced the activity of plasma transaminases and improved the histological signs of acute liver damage in CCl 4 -intoxicated mice. Quercetin prevented the decrease in Cu/Zn SOD activity in CCl 4 -intoxicated mice more potently than rutin. However, it was less effective in the suppression of nitrotyrosine formation. Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl 4 -induced activation of nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α) and cyclooxygenase (COX-2). The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin. Treatment with both flavonoids significantly increased NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO-1) expression in injured livers, although quercetin was less effective than rutin at an equivalent dose. Quercetin more potently suppressed the expression of transforming growth factor-β1 (TGF-β1) than rutin. Conclusion: Rutin exerts stronger protection against nitrosative stress and hepatocellular damage but has weaker antioxidant and antiinflammatory activities and antifibrotic potential than quercetin, which may be attributed to the presence of a rutinoside moiety in position 3 of the C ring.

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“…Apalagi masyarakat sekitar sering menggunakan wadah penyimpanan yang berwarna gelap. Oksidasi ini menyebabkan terbentuknya senyawa hidroperoksida yang tidak stabil dan bertanggung jawab terhadap perubahan rasa dan bau minyak kelapa (Vladimir-Knezevic et al, 2011). Senyawa hidroperoksida dapat membentuk malondialdehida yang ditunjukkan dengan bilangan TBA sebagai indikator ketengikan minyak kelapa (Angelo, 1996).…”

Section: Ekstraksi Sampelunclassified

Antioxidant Activity of Cashew Apple Dreg Extract and Their Effect in Traditional Processing of Coconut Oil

Anwar

2017

ALCHEMY J.Pen.Kim

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ABSTRAKPenelitian ini bertujuan untuk menentukan aktivitas antioksidan ekstrak ampas buah semu jambu mete dan kemampuannya sebagai antioksidan pada pengolahan minyak kelapa secara tradisional. Aktivitas antioksidan ditentukan melalui metode 2,2-difenil-1-pikrilhidrazil (DPPH). Penelitian ini menunjukkan seluruh fraksi ekstrak etanol mengandung senyawa flavonoid dan tanin/polifenol dan juga memiliki aktivitas antioksidan. Ekstrak etanol ampas buah semu jambu mete memiliki persen inhibisi tertinggi. Berbeda dengan fraksi n-heksan yang memiliki IC 50 terendah. Aplikasi pada pengolahan minyak kelapa tradisional menunjukkan penambahan ekstrak etanol sebesar 2,5 % menunjukkan hasil terbaik berdasarkan pada nilai angka peroksida dan bilangan TBA.Kata kunci : antioksidan, buah semu jambu mete, DPPH, minyak kelapa. ABSTRACTThe aim of this study was to determine antioxidant activity of cashew apple dreg extract and their antioxidant activity in traditional processing of coconut oil. Cashew apple dreg was extracted by ethanol and fractionation by DCM, n-hexane and water. The antioxidant activity from dreg extract was determined using 2,2-diphenyl-1-pycrylhydrazil (DPPH). The result showed that all ethanol fractions of cashew apple dreg contain flavonoid and tannins/polyphenols. Based on scavenging DPPH all of ethanol fractions showed antioxidant activity. The greatest DPPH inhibition was observed for ethanol extract. On the contrary, n-hexane fraction showed the lowest IC 50 . Application in traditional processing of coconut oil showed that the addition 2,5 % ethanol extract provide the best product according to the lower content of peroxide value and TBA number.

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Antioxidant Activities and Polyphenolic Contents of Three Selected Micromeria Species from Croatia

Cited by 131 publications

References 38 publications

Phytochemical screening and antioxidant capacity of the aerial parts of Thymelaea hirsuta L.

Phytochemical screening and antioxidant capacity of the aerial parts of Thymelaea hirsuta L.

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

Antioxidant Activity of Cashew Apple Dreg Extract and Their Effect in Traditional Processing of Coconut Oil

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