Antioxidant activities of methanol extracts ofCurculigo pilosarhizome andGladilous psittascinuscorm against lipid peroxidation in rat’s liver and heart

Karigidi, Kayode Olayele; Ojebode, Mojisola; Anjorin, Oluwasegun Joseph; Omiyale, Benjamin Olusola; Olaiya, Charles O.

doi:10.1080/10496475.2018.1510457

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…Extraction of the sample was done with the protocol of Karigidi et al (2019). 200 g of powdered A. paniculata were soaked in 1000 ml of methanol.…”

Section: Extraction Of Samplementioning

confidence: 99%

Antioxidant activities and GC-MS profiling of fractions of methanol extract of Andrographis paniculata

Benjamin¹,

Kayode²

2023

Afr. J. Biotechnol.

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This study was intended to investigate the antioxidant activities of different solvent fractions (hexane (HEX), chloroform (CHL), ethylacetate (ETHYL) and methanol (MET) fractions) of methanol extract ofAndrographis paniculata and GC-MS profiling of the most active fraction (MET). The crude methanol extract was fractionated using vacuum liquid chromatography method. Antioxidant activity was evaluated using total phenolic content (TPC), total flavonoid content (TFC), total antioxidant capacity (TAC), ferric reducing antioxidant potential (FRAP) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH), 2, 2azobis-3-ethylbenzothiazoline-6-sulfonate (ABTS), and Nitric oxide (NO) radical scavenging abilities. GC-MS was conducted to determine phytochemical present in methanol fraction. The results indicated that MET possessed significantly (p < 0.05) higher TPC (33.98 ±1.63 mg GAE/g), TFC (15.81 ± 0.9 5mg QUE/g), TAC (21.44 ± 0.29 mg AAE/g) and FRAP (57.87 ± 0.88 mg Fe 2+ /g) than the other fractions. Also, MET exhibited the highest scavenging (ABTS, DPPH and NO) abilities of all the fractions. The GC-MS profiling of methanol fraction showed abundance presence of 2, 5-octadecadienoic-methyl ester and hexadecanoic acid-methyl ester. In conclusion, various fractions of A. paniculata have antioxidant abilities and could be used in diseases associated with free radicals.

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“…Extraction of the sample was done with the protocol of Karigidi et al (2019). 200 g of powdered A. paniculata were soaked in 1000 ml of methanol.…”

Section: Extraction Of Samplementioning

confidence: 99%

Antioxidant activities and GC-MS profiling of fractions of methanol extract of Andrographis paniculata

Benjamin¹,

Kayode²

2023

Afr. J. Biotechnol.

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“…The Curculigo pilosa (C. pilosa) Schum and Thom plant belongs to the family Hypoxidaceae. The rhizomes of the C. pilosa plant possess medicinal properties (bioactive constituents) that are used as food for adults and infants, as well as in the management and treatment of several diseases [16][17][18][19][20][21], but the mechanism of action is yet to be understood. Therefore, this study aims to investigate the effect of an aqueous extract of C. pilosa rhizome on the activities of some oxidative stress marker enzymes (catalase, reduced glutathione, and superoxide dismutase), as well as the serum concentration of lipid profiles (cholesterol, triglycerides, and phospholipid) of para-hydroxy acetanilide (pPHA)-induced toxicity in rats.…”

Section: Introductionmentioning

confidence: 99%

Curculigo pilosa rhizome Supplementation Reverses P-Hydroxyacetanilide-Induced Oxidative Stress and Lipid Profile Dysfunction in Rats

Olabisi,

Oluwaseyi,

Iweunor

et al. 2023

AJRB

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Exposure to drug toxicity results in stress and dysfunction of metabolizing enzymes that cause illnesses and diseases. Consumption of medicinal plant rhizomes is a regime for managing the complications. On the activities of some oxidative stress marker enzymes (catalase, glutathione, and superoxide dismutase), as well as the concentration of lipid profiles (cholesterol, triglycerides, and phospholipids) of p-hydroxyacetanilide (pPHA)-induced toxicity in rats, the effects of an aqueous extract of Curculigo pilosa (C. pilosa) rhizome were assessed. Forty rats were randomly grouped into eight groups (n = 5). The control group; aqueous extract of C. pilosa rhizome group; 750 mg/kg and 1000 mg/kg per body weight of pPHA group; the preventive groups (aqueous extract of C. pilosa rhizome and 750 mg/kg per body weight of pPHA; aqueous extract of C. pilosa rhizomes and 1000 mg/kg per body weight of pPHA); and the curative groups (750 mg/kg per body weight of pPHA and aqueous extract of C. pilosa rhizome; 1000 mg/kg body weight of pPHA and aqueous extract of C. pilosa rhizome). The oxidative stress marker enzymes and lipid profiles were analyzed spectrophotometrically in the serum, kidney, brain, and liver of the animals on the seventh and fourteenth days after the administrations. The results show that pPHA decreases the oxidative stress marker activities and the lipid profile concentrations in all the compartments, but the pre- and post-treatment with an aqueous extract of C. pilosa rhizome improved the activities of the stress marker enzymes and the lipid profiles dysfunction. The result suggests that an aqueous extract of C. pilosa rhizome has preventive and curative therapeutic potential for pPHA-induced toxicity.

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“…Reactive oxygen (ROS) and nitrogen (RNS) species are free radicals having a short life due to their instability, thus highly reactive with biological substances. These free radical species alter the structural and functional properties of biological molecules and result in "Oxidative Stress" (Karigidi et al, 2019). These free radicals increase the rate of ageing and loss of cell function due to the degradation of macromolecules like DNA, RNA, lipid and protein (Kotásková et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The antioxidant activity, total phenolic and monomeric anthocyanin content of Gymnema sylvestre leaf aqueous extract

Abhiram,

Briyangari,

Sivakanesan

2023

J. Dry Zone Agric.

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The Gymnema sylvestre is a widely recognized medicinal plant, particularly for its effectiveness in treating diabetes. Aim of this study is to measure the antioxidant property, polyphenol and anthocyanin content of G. sylvestre aqueous extract using various in-vitro techniques. The aqueous extract was prepared and total phenolic compounds (TPC), DPPH (2,2-Diphenyl-1-Picrylhydrazyl) radical scavenging ability, total antioxidant activity using ferric reducing antioxidant power (FRAP), ferric reducing power and monomeric anthocyanin content were estimated. Correlation analyses were performed for TPC and anthocyanin against the antioxidant activity. The TPC was 4.55±0.34 mg g-1 of fresh leaf weight (FLW) and the IC50 value for DPPH radical scavenging ability was 2.40 mg mL-1 of leaf extract concentration. The percentage of inhibition strongly correlated (R2 = 0.99) with the concentration of the leaf extract. The total antioxidant power of the leaf extract was 21.06±1.74 μmol g-1 of FLW.The ferric-reducing power showed a positive correlation with the leaf concentration (R2 = 0.99). The anthocyanin content of the leaf extract was 167.84±1.45 mg per 100 g of leaf. The TPC and anthocyanin exhibited strong positive correlations with total antioxidants and DPPH, but a weak correlation with reducing power. The antioxidant properties of leaf extract could be ascribed to the presence of TPC and anthocyanin as it showed a strong correlation with antioxidant activity. This is the first study that reported the anthocyanin content of G. sylvestre leaf extract. This study found G. sylvestre leaf water extract has antioxidant properties and contains a significant amount of TPC and monomeric anthocyanin.

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Antioxidant activities of methanol extracts ofCurculigo pilosarhizome andGladilous psittascinuscorm against lipid peroxidation in rat’s liver and heart

Cited by 9 publications

References 18 publications

Antioxidant activities and GC-MS profiling of fractions of methanol extract of Andrographis paniculata

Antioxidant activities and GC-MS profiling of fractions of methanol extract of Andrographis paniculata

Curculigo pilosa rhizome Supplementation Reverses P-Hydroxyacetanilide-Induced Oxidative Stress and Lipid Profile Dysfunction in Rats

The antioxidant activity, total phenolic and monomeric anthocyanin content of <em>Gymnema sylvestre</em> leaf aqueous extract

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