Antioxidant activity and rosmarinic acid content of ultrasound-assisted ethanolic extracts of medicinal plants

Nicolai, Marisa; Pereira, Paula; Vítor, Rute F.; Reis, Catarina Pinto; Roberto, Amílcar; Rijo, Patrícia

doi:10.1016/j.measurement.2016.04.033

Cited by 57 publications

(42 citation statements)

References 14 publications

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“…Regarding the intrinsic factors of HAE, UAE and MAE, although worthy conclusions can be derived from the consulted bibliographic material [10,17,35], results may be highly dependent on variations not directly foreseen in these studies. Thus, to optimize the response criteria the following ranges for the intrinsic factors were used: for HAE t (30-150 min) and T (30-90°C); for MAE t (3-45 min) and T (60-180°C); and for UAE t (3-45 min) and P (100-500 W).…”

Section: Resultsmentioning

confidence: 91%

“…Although there are scientific documents dealing with RA extraction from natural matrices [10,17,35], no complete studies could be found describing the conditions of RA extraction from M. officinalis leaves and the effects of the main process variables of conventional and alternative extraction techniques, as well as the comparison between them. In general, the leaves of Rosmarinus officinalis are the most studied plant material for the extraction of RA.…”

Section: Resultsmentioning

confidence: 99%

“…Due to the RA chemical structure, the use of different water-based solvent mixtures are generally used as the extraction solvent, where the combination of water with different contents of methanol, ethanol or acetone are applied [10,35,36]. Considering the principles of green chemistry, binary mixtures of ethanol with water were selected as the extraction solvent.…”

Section: Resultsmentioning

confidence: 99%

“…The most relevant are supercritical carbon dioxide extraction, liquid CO 2 extraction, UAE, MAE and HAE [38][39][40]. There are few works that compare the conventional and alternative extraction techniques [10,17,35]. In a previous study Ince et al [17], the extraction of RA from the leaves of lemon balm was formulated through three techniques (HAE UAE and MAE) using water as solvent.…”

Section: Comparison With Other Studies Involving the Extraction Of Romentioning

confidence: 99%

“…For comparison purposes, some authors have studied the possibility of obtaining RA from six different plants using UAE, concluding that Hypericum perforatum was the plant providing the highest RA yield (0.99 mg/g dw), followed by M. officinalis (0.62 mg/g dw) and R. officinalis (0.51 mg/g dw) [35]. Bellumori et al [20], using R. officinalis reported the value of 67.7 mg/g dw (UAE), and a much lower one with MAE (32.9 mg/g dw).…”

Section: Comparison With Other Studies Involving the Extraction Of Romentioning

confidence: 99%

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Extraction of rosmarinic acid from Melissa officinalis L. by heat-, microwave- and ultrasound-assisted extraction techniques: A comparative study through response surface analysis

Caleja

Barros

Prieto

et al. 2017

Separation and Purification Technology

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a b s t r a c tThe goal of this study was to compare the extraction of rosmarinic acid from Melissa officinalis L. using three techniques (heat--, microwave-and ultrasound-assisted extraction). In order to obtain the conditions that maximize the rosmarinic acid extraction, a response surface methodology was applied using the circumscribed central composite design of three variables with five levels. The relevant independent variables used for the process optimization were time, temperature and ethanol-water proportion for heat-assisted-and microwave-extration, whereas for the ultrasound method the ultrasonic power was variable. The responses used as criteria were the amount of rosmarinic acid was determined by HPLCDADand the extraction yield of the obtained residue. Ultrasound extraction proved to be the most effective method, capable of yielding 86.3 ± 4.1 mg rosmarinic acid/g plant per dry weight (dw) at the optimal extraction conditions (33.0 ± 3.2 min, 371.7 ± 19.3 W and 39.9 ± 1.4% of ethanol). According to the content of rosmarinic acid, microwave-and heat-assisted extractions techniques were less effective, producing 49.4 ± 2.3 (at 26.5 ± 2.1 min, 108.6 ± 10.2°C and 25.5 ± 0.9% of ethanol) and 59.4 ± 2.2 (at 106.2 ± 5.1 min, 88.0 ± 2.9°C and 34.5 ± 1.6% of ethanol), respectively. Additionally, the solid/liquid ratio effect at the optimal values in a dose-response format was studied in view of its plausible transference at industrial level, showing a decreasing non-linear pattern from 5 to 120 g/L. In brief, the obtained results highlight the potential applications of using the leaves from M. officinalis as a source of rosmarinic acid.

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Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Comparison With Other Studies Involving the Extraction Of Romentioning

confidence: 99%

Section: Comparison With Other Studies Involving the Extraction Of Romentioning

confidence: 99%

See 3 more Smart Citations

Extraction of rosmarinic acid from Melissa officinalis L. by heat-, microwave- and ultrasound-assisted extraction techniques: A comparative study through response surface analysis

Caleja

Barros

Prieto

et al. 2017

Separation and Purification Technology

View full text Add to dashboard Cite

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Seed Polyphenolic Profile, Antioxidative Activity, and Fatty Acids Composition of Wild and Cultivated Carthamus Species

Karami

Rahimmalek

2018

Chemistry & Biodiversity

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Total flavonoid content (TFC) and cyanidin-3-glucoside (Cyd-3-glu) of seed and seed coat extract of 16 genotypes from five species of Carthamus were studied, and their major polyphenolic compounds and antioxidant activity of the seed coat extracts were determined using HPLC analysis and DPPH assay, respectively. Additionally, fatty acids composition of the seed oil was analyzed by GC. In general, TFC and Cyd-3-glu content of seed coat extracts were higher than those of seed extracts. A novel breeding line with black seed coat (named A82) depicted lower TFC (3.79 mg QUE/g DW) but higher Cyd-3-glu (24.64 mg/g DW) compared to the white and other seed-pigmented genotypes. DPPH radical scavenging activity showed a strong association with Cyd-3-glu content (r = 0.84), but no correlation with TFC (r = -0.32). HPLC analysis of seed coat extracts revealed that four compounds were dominant constituents including rutin (7.23 - 117.95 mg/100 g DW), apigenin (4.37 - 64.88 mg/100 g DW), quercetin (3.09 - 14.10 mg/100 g DW), and ferulic acid (4.49 - 30.41 mg/100 g DW). Interestingly, the genotype A82 with an appropriate polyunsaturated/saturated fatty acids index (5.46%) and a moderate linoleic fatty acid content (64.70%) had higher nutritional and pharmaceutical value than all the other genotypes.

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UPLC–PDA‐ESI–QTOF–MS/MS and GC‐MS analysis of Iranian Dracocephalum moldavica L.

Fattahi

Shakeri

Tayarani‐Najaran

et al. 2021

Food Science & Nutrition

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Antioxidant activity and rosmarinic acid content of ultrasound-assisted ethanolic extracts of medicinal plants

Cited by 57 publications

References 14 publications

Extraction of rosmarinic acid from Melissa officinalis L. by heat-, microwave- and ultrasound-assisted extraction techniques: A comparative study through response surface analysis

Extraction of rosmarinic acid from Melissa officinalis L. by heat-, microwave- and ultrasound-assisted extraction techniques: A comparative study through response surface analysis

Seed Polyphenolic Profile, Antioxidative Activity, and Fatty Acids Composition of Wild and Cultivated Carthamus Species

UPLC–PDA‐ESI–QTOF–MS/MS and GC‐MS analysis of Iranian Dracocephalum moldavica L.

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