Antioxidant activity of ethanolic extract of Penicillium chrysogenum and Penicillium fumiculosum

Abstract

The aim of this study was to investigate the biological and chemical activity on two species of fungi of the genus Penicillium isolated from wastewater. On the selected species of fungi the different antioxidant activity assays were carried out: DPPH free-radical scavenging activity, total antioxidant activity, Fe2+- chelating ability and Fe3+- reducing power. Total phenol content was also determinate for ethanolic extract of mycelia. Penicillium chrysogenum ethanolic extract contained higher total phenolic content and better total antioxidant capacity as well as ferrous ion chelating ability. Penicillium fumiculosum ethanolic extract showed higher DPPH free-radical scavenging activity, as well as reducing power. Based on the obtained results it can be concluded that two types of fungi are potential new sources of natural antioxidants. [Projekat Ministarstva nauke Republike Srbije, br. III 43004]

Chemical Composition of Aspergillus creber Extract and Evaluation of its Antimicrobial and Antioxidant Activities

“…The slight difference between the antioxidant capacities of EAF and ascorbic acid may be explained either by the purity of ascorbic acid, whereas the extract of A. creber is a mixture of multiple compounds or by the capacity of some compounds in the fungal extract to neutralize or to inhibit the effect of active compounds (Dhankhar et al 2012). Moreover, our data revealed that A. creber is able to produce much higher content of phenols than the other filamentous fungi in the literature (Jakovljević et al 2014;Smith et al 2015;Sugiharto et al 2016). Many previous studies attributed the antioxidant activity of filamentous fungi to their TPC (Abdel-Monem et al 2013;Smith et al 2015, Nwobodo et al 2017.…”

“…Antioxidant analysis 2,2-diphenyl-1-picryl hydrazyl (DPPH) assay. The DPPH radical scavenging activity was determined according to Jakovljević et al (2014). Different concentrations of EAF were prepared: 12.5, 25, 50, 100, 200, 400 µg/ml.…”

Mycochemical Screening and Analysis, Antioxidant Activity, and Biochemical Composition of Fermentation Strain Snef1216 (Penicillium chrysogenum)

“…However, natural resources of mycochemicals are safe and better substitutes for chemical antioxidants [5]. Fungi are an important source of natural antioxidants because of their natural ability to produce secondary metabolites [6]. ey contain antioxidants in the form of steroids, quinones, alkaloids, phenylpropanoids, tocopherol, phenols, tannins, lactones, terpenoids, triterpenes carotenoids, and flavonoids [7].…”

“…Essential mycochemicals contained in fungi such as phenolic contents have attained more interest due to their characteristics to inhibit disease by their antioxidant activity. Phenols and flavonoids are the major secondary metabolites of fungi [6]. Moreover, phenolic and flavonoids contents of fungal origin act as potential therapeutic agents, i.e., antimutagenic, antibiotics, anticarcinogenic, and antioxidants [8].…”

“…Penicillin was the first antibiotic that was isolated from this species, and their biologically active secondary metabolites were the topic of intensive study in recent decades [11]. Many biologically active substances were isolated from P. chrysogenum such as tannins, alkaloids, terpenoids, and tannins [6]. It was found that the species of Penicillium produced scavenged DPPH radicals [14].…”