Antioxidant Activity of Hizikia fusiformis on Reactive Oxygen Species Scavenging and Lipid Peroxidation Inhibition

Abstract

Water and organic extracts (diethyl ether, chloroform, ethyl acetate, acetone, ethanol and methanol) obtained from Hizikia fusiformis were screened on reactive oxygen species (ROS) scavenging assays (1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide anion, hydrogen peroxide and hydroxyl radical) and lipid peroxidation (inhibition of linoleic acid oxidation) inhibitory assays. Water, methanol and ethanol extracts showed significant ROS radical scavenging activities. Water extracts showed high scavenging activities on hydrogen peroxide (around 76%) and DPPH radicals (around 75%) while it presented a moderate scavenging activity on hydroxyl radicals (around 54%). Comparatively higher ROS scavenging activities were recorded in hydroxyl radical and DPPH scavenging assays. DPPH radical scavenging activities were well correlated with the polyphenolic content. ROS scavenging and lipid peroxidation inhibition activities indicated that H. fusiformis might be a valuable natural antioxidative source containing both water and fatsoluble antioxidative components.

Seasonal variations in the phenolic compound content and antioxidant activities of three selected species of seaweeds from Tiskerth islet, Bejaia, Algeria

“…It was observed that the extracts containing high levels of total phenolics were also potent in reducing ferric iron, suggesting that algal polyphenols may be the principle constituents responsible for these properties of the extracts [13]. Furthermore, many researchers have been reported positive correlation between free radical scavenging activity and total phenolic compound [44][45][46].This is in disagreement with our results that prove weak free radical scavenging activity in all studied species. Some studies showed also a low activity in water extracts [47][48].…”

Evaluation of antioxidant activity and total phenol content of Gracilaria bursa-pastoris harvested in Nador lagoon for an enhanced economic valorization

“…More recently, Jimenez-Escrig et al [37] determined that the DPPH-free radical scavenging by brown and red algal extracts were positively correlated with the total polyphenol content of these extracts. Several studies have demonstrated a highly significant correlation between the phenolic content and the antioxidant activity in seaweed extracts, [38][39][40][41]. These results suggest that the antioxidant activity of G. bursa-pastoris extracts could be correlated with its high phenolic content.…”

Effect of Hizikia fusiformis extracts on reactive oxygen species mediated oxidative damage

“…Yan et al (1999) reported the 2,2-diphenyl-1-picrylhydrazyl(DPPH) radical scavenging activity of H. fusiformis (65% in methanol extract) and identified the major antioxidant carotenoid as all-trans-fucoxanthin. Siriwardhana et al (2003) showed that water, methanol, and ethanol extracts from H. fusiformis had ROS and DPPH radical scavenging activities, and these activities were well-correlated with polyphenolic content. Jang et al (2005) demonstrated that boiled water extract (BWE) from H. fusiformis exhibited the antioxidant properties by scavenging free radicals and inhibiting lipid peroxidation.…”