Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds

Rai, Sujay; Wahile, Atul; Mukherjee, Kakali; Saha, B. P.

doi:10.1016/j.jep.2005.09.025

Cited by 258 publications

(173 citation statements)

References 27 publications

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“…The reason for this increment in catalase level should be further evaluated. Rai et al (2006) have explained that administration of Nelumbo nucifera seeds was found to be increased the level of catalase enzyme dose dependently. But in our present research work the level of enzyme catalase was found to be decreased dose dependently.…”

Section: Discussionmentioning

confidence: 99%

“…They are astringent, cardio tonic, febrifuge, hypotensive, resolvent, stomachic, styptic, tonic and vasodilator. Rai et al (2006) mentioned the anti-diarrheal, psychopharmacological, diuretic, antipyretic, antimicrobial, hypoglycemic activity of Nelumbo nucifera. A decoction of the flowers is used in the treatment of premature ejaculation (Duke et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant activity of Nelumbo nucifera (Gaertn) flowers in isolated perfused rat kidney

Krishnamoorthy¹,

Chellappan²,

Joseph³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Atividade antioxidante das flores de Nelumbo nucifera (Gaertn) em rim isolado perfundido de rato". A padronização da indução de estresse oxidativo com a mstura de Fenton em rim isolado perfundido de rato e a avaliação do efeito antioxidante das flores de Nelumbo nucifera em rim isolado de rato oxidativamente estressado são realizadas no presente estudo. Seis grupos de rim isolado perfundido de rato foram utilizados para o presente estudo. O grupo I de rins recebeu veículo. O grupo II de rins foi oxidativamente estressados com a mistura de Fenton. Os grupos III e IV de animais foram tratados com duas doses graduais de extrato após a administração da mistura de Fenton. Os grupos V e VI de rins foram perfundidos com duas doses graduais de extrato sem a mistura de Fenton. A mistura de Fenton causou estresse oxidativo com diferença significativa de malondialdeído (TBARS), glutationa reduzida (GSH), glutationa peroxidase (GPx), catalase, glutamato oxaloacetato transaminase (GOT) e glutamato piruvato transaminase (GPT) (p<0,05) em ratos doentes. No tratamento dos animais com extrato, o estresse oxidativo foi diminuído com aumento nos antioxidantes e as enzimas marcadoras mantiveram o nível normal. Este efeito do extrato foi dependente da dose. Em conclusão, a mistura de Fenton desenvolveu o estresse oxidativo em rim isolado perfundido de rato e o extrato das flores de Nelumbo nucifera apresenta atividade antioxidante no rim isolado perfundido oxidativamente estressado. Unitermos:Nelumbo nucifera, Nymphaceae, mistura de Fenton, malondialdeído, GOT, rim isolado perfundido.ABSTRACT: Standardization of induction of oxidative stress with Fenton mixture in isolated perfused rat kidney and evaluation of antioxidant effect of Nelumbo nucifera flowers in isolated oxidatively stressed rat kidney are carried out in present study. Six groups of isolated perfused rat kidney were used for the present study. Group I kidneys were received vehicle. Group II kidneys were oxidatively stressed with Fenton mixture. Group III and IV animals were treated with two graded doses of extract after the administration of Fenton mixture. Group V and VI kidneys were perfused with two graded doses of extract without Fenton mixture. Fenton mixture was found to cause oxidative stress with significant difference of malondialdehyde (TBARS), Reduced glutathione (GSH), Glutathione peroxidase (GPx), catalase, Glutamate Oxaloacetate Transaminase (GOT) and Glutamate Pyruvate Transaminase (GPT) (p<0.05) in diseased rats. On treating animals with extract, the oxidative stress was decreased with increase in antioxidants and the marker enzymes were found to maintain the normal level. This effect of extract was found to be dose dependent. In conclusion, Fenton mixture developed the oxidative stress in isolated perfused rat kidney and Nelumbo nucifera flowers extract exhibits antioxidant activity in that oxidatively stressed isolated perfused kidney.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant activity of Nelumbo nucifera (Gaertn) flowers in isolated perfused rat kidney

Krishnamoorthy¹,

Chellappan²,

Joseph³

et al. 2009

Rev. bras. farmacogn.

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“…The nitric oxide (NO · ) scavenging activity of the samples was determined according to the method described by Rai et al [20] with a slight modification. The NO · generated from sodium nitroprusside in an aqueous solution at physiological pH interacts with oxygen to produce nitrite ions, which were measured by the Griess reaction.…”

Section: Nitric Oxide Radical Scavenging Assaymentioning

confidence: 99%

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

et al. 2012

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Aim: To investigate the mechanisms underlying the protective effects of quercetin-rutinoside (rutin) and its aglycone quercetin against CCl 4 -induced liver damage in mice. Methods: BALB/cN mice were intraperitoneally administered rutin (10, 50, and 150 mg/kg) or quercetin (50 mg/kg) once daily for 5 consecutive days, followed by the intraperitoneal injection of CCl 4 in olive oil (2 mL/kg, 10% v/v). The animals were sacrificed 24 h later. Blood was collected for measuring the activities of ALT and AST, and the liver was excised for assessing Cu/Zn superoxide dismutase (SOD) activity, GSH and protein concentrations and also for immunoblotting. Portions of the livers were used for histology and immunohistochemistry. Results: Pretreatment with rutin and, to a lesser extent, with quercetin significantly reduced the activity of plasma transaminases and improved the histological signs of acute liver damage in CCl 4 -intoxicated mice. Quercetin prevented the decrease in Cu/Zn SOD activity in CCl 4 -intoxicated mice more potently than rutin. However, it was less effective in the suppression of nitrotyrosine formation. Quercetin and, to a lesser extent, rutin attenuated the inflammation in the liver by down-regulating the CCl 4 -induced activation of nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α) and cyclooxygenase (COX-2). The expression of inducible nitric oxide synthase (iNOS) was more potently suppressed by rutin than by quercetin. Treatment with both flavonoids significantly increased NF-E2-related factor 2 (Nrf2) and heme oxygenase (HO-1) expression in injured livers, although quercetin was less effective than rutin at an equivalent dose. Quercetin more potently suppressed the expression of transforming growth factor-β1 (TGF-β1) than rutin. Conclusion: Rutin exerts stronger protection against nitrosative stress and hepatocellular damage but has weaker antioxidant and antiinflammatory activities and antifibrotic potential than quercetin, which may be attributed to the presence of a rutinoside moiety in position 3 of the C ring.

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“…The total phenolic compounds were determined using Folin-Ciocalteau's method (Rai et al, 2006), total flavonoids using aluminum chelating method (Ebrahimzadeh et al, 2008) and proanthocyanidins content was obtained after acid depolymerization to the corresponding anthocyanidins (Rösch et al, 2003).…”

Section: Determination Of Phenolic Flavonoid and Proanthocyanidins Cmentioning

confidence: 99%

Protective action against chemical-induced genotoxicity and free radical scavenging activities of Stryphnodendron adstringens ("barbatimão") leaf extracts

Filho¹,

Ferreira²,

Gouvêa³

2011

Rev. bras. farmacogn.

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The present study describes for the first time the antigenotoxic and antioxidant properties of Stryphnodendron adstringens (Mart.) Coville, Fabaceae ("barbatimão") leaves. The aqueous (AEB), water fraction (WFB) and ethanolic (EEB) extracts of leaves were obtained and they presented high content of phenolic compounds, flavonoids and proanthocyanidins. WFB and EEB inhibited the genotoxicity induced by cyclophosphamide. WFB inhibited the DNA lesion formation and both WFB and EEB decreased significantly (p<0.05) micronucleus formation. All extracts also showed high DPPH radical scavenging activity and reducing power. In conclusion all extracts presented antioxidant activity and WFB and EEB protected cells from genotoxicity induced by cyclophosphamide in rat bone marrow cells. Thus, our results support the beneficial effects of the barbatimão extracts as an anticarcinogenic agent.

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Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds

Cited by 258 publications

References 27 publications

Antioxidant activity of Nelumbo nucifera (Gaertn) flowers in isolated perfused rat kidney

Antioxidant activity of Nelumbo nucifera (Gaertn) flowers in isolated perfused rat kidney

Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB/cN mice

Protective action against chemical-induced genotoxicity and free radical scavenging activities of Stryphnodendron adstringens ("barbatimão") leaf extracts

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