Antioxidant and Anti-inflammatory activities of the flower extracts of Argemone mexicana L.

Prabhakaran, Dorairaj; Rajeshkanna, A.; Senthamilselvi, M. M.

doi:10.26452/ijrps.v11i1.1824

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…Argemone mexicana , a stress-resistant member of the Papaveraceae family of plants, has been reported to possess a wide-range of biological activities, such as antibacterial [ 9 – 12 ], antifungal [ 13 – 16 ], antiviral [ 17 – 19 ], anthelmintic [ 20 – 22 ], antioxidant [ 23 – 25 ] and cytotoxic/anticancer [ 15 , 26 , 27 ] actions. This plant is native to the West Indies, but today it can also be found in Mexico and throughout the Americas [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana

et al. 2021

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Commonly called the Mexican prickly poppy, Argemone mexicana is a stress-resistant member of the Papaveraceae family of plants that has been used in traditional medicine for centuries by indigenous communities in Mexico and Western parts of the United States. This plant has been exploited to treat a wide variety of ailments, with reported antimicrobial and antioxidant properties, as well as cytotoxic effects against some human cancer cell lines. Due to its various therapeutic uses and its abundance of secondary metabolites, A. mexicana has great potential as a drug discovery candidate. Herein, the germination conditions of A. mexicana are described and the cytotoxic activities of different parts (seeds, leaves, inner vs. outer roots) of the plant from methanol or hexane extracts are preliminarily characterized against cells of seven unique organisms. When comparing 1 mg of each sample normalized to background solvent alone, A. mexicana methanol outer root and leaf extracts possessed the strongest antimicrobial activity, with greatest effects against the Gram-positive bacteria tested, and less activity against the Gram-negative bacteria and fungi tested. Additionally, using the MTT colorimetric assay, the outer root methanol and seed hexane extracts displayed pronounced inhibitory effects against human colon cancer cells. Quantification of c-MYC (oncogene) and APC (tumor suppressor) mRNA levels help elucidate how the A. mexicana root methanol extract may be affecting colon cancer cells. After ultra-performance liquid chromatography coupled with mass spectrometry and subsequent nuclear magnetic resonance analysis of the root and leaf methanol fractions, two main antibacterial compounds, chelerythrine and berberine, have been identified. The roots were found to possess both phytocompounds, while the leaf lacked chelerythrine. These data highlight the importance of plants as an invaluable pharmaceutical resource at a time when antimicrobial and anticancer drug discovery has plateaued.

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Section: Introductionmentioning

confidence: 99%

Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana

et al. 2021

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“…According to reports from earlier investigations, A. mexicana's diverse plant parts have a range of in vitro and in vivo pharmacological actions [12]. Among these, the cytotoxic activity of the alkaloids such as chelerythrine, berberine, and sanguinarine isolated from the chloroform fraction of the aerial part of A. mexicana [25,113], the antioxidant and wound healing activities of chitosan favonoids isolated from the n-butanol fraction of the leaves of A. mexicana [114], the antioxidant and antiinfammatory activities of phenols and favonoids extracted from the EAF of the fowers of A. mexicana [14,102], and the anti-infammatory activity of isorhamnetin-3-Oβ-D-glucopyanoside, cysteine, and phenylalanine β-amyrin derived triterpenoids from the leaves, seeds, and roots extract of A. mexicana [115] were investigated. Additionally, earlier study fndings showed that the A. mexicana aqueous leaves extract signifcantly reduced edema (76.75%) at the highest tested dose of the extract which compares favorably to the 400 mg/ kg dose of ethyl acetate fraction the results of the current test in the same anti-infammatory model [116].…”

Section: Discussionmentioning

confidence: 99%

“…mexicana [ 114 ], the antioxidant and anti-inflammatory activities of phenols and flavonoids extracted from the EAF of the flowers of A . mexicana [ 14 , 102 ], and the anti-inflammatory activity of isorhamnetin-3-O β -D-glucopyanoside, cysteine, and phenylalanine β -amyrin derived triterpenoids from the leaves, seeds, and roots extract of A . mexicana [ 115 ] were investigated.…”

Section: Discussionmentioning

confidence: 99%

“…Argemone mexicana L. (Figure 1) which belongs to the family of Papaveraceae, is naturalized throughout the world's tropical and subtropical regions and grows as a prickly poppy shrub [8][9][10][11][12]. A. mexicana has been studied in vitro and in vivo for a variety of biological activities of numerous solvent extracts of the various parts of the plant; for example, it is used in the indigenous system of medicine as an analgesic and antiinfammatory [13][14][15], antiurolithiatic [16], anticancer [17,18], antioxidant [18], thrombolytic [19], antidiabetic [20][21][22], antiarthritic [23], cytotoxic [24,25], antipsychotic [26], antepileptics [27], apoptotic [18,28], aphrodiasic [29], antiasmatic [30], antihepatotoxic [31], nematocidal [32], antischistosomal [33], and antimalarial [34,35] wound healing [36,37] activities.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Ayele

Abebe

Muche

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Introduction. The solvent fractions of the fruits of Argemone mexicana L. (Papaveraceae) have not yet been explored scientifically for in vivo wound healing and anti-inflammatory activities. The objective of this study was, therefore, to evaluate in vivo wound healing and anti-inflammatory activities of the solvent fractions of the fruit of Argemone mexicana L. (Papaveraceae) in rats. Method. The crude extract of Argemone mexicana was fractionated with n-hexane, ethyl acetate, and distilled water. Wound healing activity was evaluated using excision and incision wound models while anti-inflammatory activity was evaluated using carrageenan-induced rat paw and cotton pellet-induced granuloma models. The fractions were evaluated at 5 and 10% ointments using moist-exposed burn ointment as the standard drug, and 100, 200, and 400 mg/kg test doses using aspirin, and dexamethasone as standard drugs for wound healing and anti-inflammatory activities, respectively. All treatment administrations were made orally for anti-inflammatory activity and applied topically for wound healing activity. Result. The 10% w/w ethyl acetate fraction ointment showed a significant percentage of wound contraction, reduced period of epithelialization, increased amount of fibrosis, neovascularization, and collagen tissue formation ( p < 0.01 ). The ethyl acetate fraction also showed a significant increase in tensile strength (55%; p < 0.01 ) and (81.10%; p < 0.01 ) at the tested doses of 5 and 10% w/w ointments, which was comparable to moist-exposed burn ointment. The ethyl acetate fraction also revealed a significant percent edema inhibition (61.41%; p < 0.01 ), suppression of the exudate (38.09% p < 0.01 ), and granuloma mass formations (53.47% p < 0.01 ) at the tested dose of 400 mg/kg. Conclusion. The results of this study showed that the Ethyl acetate fraction of Argemone mexicana fruit has significant wound healing and anti-inflammatory activities which support the traditional claims of the experimental plant.

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“…A. mexicana belongs to the Papaveraceae family, which possesses antibacterial [18][19][20], antifungal [21,22], antiviral [23,24], antioxidant [25,26], and cytotoxic/anticancer [27] properties. The emergence of drug-resistant microbial strains [28] has necessitated the search for antimicrobial compounds from natural sources, such as plants and marine microorganisms.…”

Section: Antimicrobial Activity Of Various a Mexicana Extractsmentioning

confidence: 99%

Analysis of Biochemical and Antimicrobial Properties of Bioactive Molecules of Argemone mexicana

et al. 2023

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This study identified phytochemicals in Argemone mexicana (A. mexicana) extracts that are responsible for its medicinal properties, and the best solvent for their extraction. The extracts of the stem, leaves, flowers, and fruits of A. mexicana were prepared at low (corresponding to room temperature) and high temperatures (corresponding to the boiling points) in various solvents, viz., hexane, ethyl acetate, methanol, and H2O. The UV-visible absorption spectra of various phytoconstituents in the isolated extracts were determined through spectrophotometry. Qualitative tests for the screening of phytoconstituents in the extracts were performed to identify various phytochemicals. We identified the presence of terpenoids, alkaloids, cardiac glycosides, and carbohydrates in the plant extracts. The antioxidant and anti-human immunodeficiency virus type 1 reverse transcriptase (anti-HIV-1RT) potential, as well as the antibacterial activity of various A. mexicana extracts were determined. These extracts showed strong antioxidant activities. The extracts exhibited antimicrobial activities against Salmonella typhi, Staphylococcus epidermis, Citrobacter, Neisseria gonorrhoeae, and Shigella flexineri. These extracts significantly inhibited HIV-1 reverse transcriptase activity. The aqueous leaf extract prepared at a temperature equivalent to the boiling point, i.e., 100 °C, was identified to be the most active against pathogenic bacteria and HIV-1 RT.

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Antioxidant and Anti-inflammatory activities of the flower extracts of Argemone mexicana L.

Cited by 5 publications

References 17 publications

Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana

Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Analysis of Biochemical and Antimicrobial Properties of Bioactive Molecules of Argemone mexicana

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