Antioxidant and Anti-malarial Properties of Catechins

Budiman, Iwan; Tjokropranoto, Rita; Widowati, Wahyu; Rahardja, Fanny; Maesaroh, Maesaroh; Fauziah, Nurul

doi:10.9734/bjmmr/2015/11451

Cited by 13 publications

(11 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thipubon et al discuss that the com-poundʼs (47) highly antioxidant activity might prevent the oxidative damage by the miceʼs immune system, consequently endorsing the parasiteʼs growth. However, there are various studies that support either the suppression or promotion of P. berghei by compound (47), which prevents the deduction of conclusions [55,71,73].…”

Section: Flavonoidsmentioning

confidence: 98%

“…Consequently, catechins (50 and 51) may act through this mechanism. The gallate substitution in these compounds appears crucial for their inhibitory activity, especially considering that gallic acid alone is inactive [33,55,71,72].…”

Section: Flavonoidsmentioning

confidence: 99%

“…Additional studies would have to be performed to analyze how these characteristics influence the activity of vismiones and anthrones. Regarding (71), because in the same study other related compounds were not tested, it is not possible to infer structure-activity links. However, from this family of compounds, it would seem safe to conclude that the quinone substitution interferes with activity and that the substitution with increasingly lipophilic chains might also improve antiplasmodial activity [96].…”

Section: Quinones Anthrones and Derivativesmentioning

confidence: 99%

See 2 more Smart Citations

Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents

et al. 2020

View full text Add to dashboard Cite

Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent, the Plasmodium sp., has a highly variable antigenicity, which accounts for the emergence and spread of resistance to all available treatments. In light of this rising problem, scientists have turned to naturally occurring compounds obtained from plants recurrently used in traditional medicine in endemic areas. Ethnopharmacological approaches seem to be helpful in selecting the most interesting plants for the search of new antiplasmodial and antimalarial molecules. However, this search for new antimalarials is complex and time-consuming and ultimately leads to a great number of interesting compounds with a lack of discussion of their characteristics. This review aims to examine the most promising antiplasmodial phenolic compounds (phenolic acids, flavonoids, xanthones, coumarins, lignans, among others) and derivatives isolated over the course of the last 28 y (1990 – 2018) and discuss their structure-activity relationships, mechanisms of action, toxicity, new perspectives they could add to the fight against malaria, and finally, the difficulties of transforming these potential compounds into new antimalarials.

show abstract

Section: Flavonoidsmentioning

confidence: 98%

Section: Flavonoidsmentioning

confidence: 99%

Section: Quinones Anthrones and Derivativesmentioning

confidence: 99%

See 1 more Smart Citation

Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Several studies demonstrate the activity of the different polyphenols purified as anti-bacterial (Arima et al2002;Borges et al 2013) and anti-parasitic (Slavic et al 2009;Budiman et al 2014;Chauhan et al 2018) agents. Recently, their potential as synergic agents and their interaction with drugs when used as anti-bacterial (Miklasińska et al 2016) and anti-parasitic (Somsak et al 2018) agents, as well as the increase of the activity of such polyphenols when they are used in a combined way, has been a topic of interest (Arima et al 2003a;Somsak et al 2018).…”

Section: Activity Against Major Infectious Diseasesmentioning

confidence: 99%

Exploring the powerful phytoarsenal of white grape marc against bacteria and parasites causing significant diseases

Rama

Mallo

Biddau

et al. 2020

Environ Sci Pollut Res

View full text Add to dashboard Cite

Natural extracts containing high polyphenolic concentration possess antibacterial, anti-parasitic and fungicidal activities. The present research characterises two extracts based on white grape marc, a winemaking by-product, describing their physicochemical features and antimicrobial capacities. The main components of these extracts are phenolic acids, flavan-3-ols and their gallates and flavonols and their glycosides. As a result of this complex composition, the extracts showed pronounced bioactivities with potential uses in agricultural, pharmaceutical and cosmetic industries. Polyphenol compounds were extracted by using hydro-organic solvent mixtures from the by-product of Albariño white wines (Galicia, NW Spain) production. The in vitro antimicrobial activity of these extracts was evaluated on Grampositive and Gram-negative bacteria and Apicomplexan and Oomycota parasites. Microbial species investigated are causing agents of several human and animal diseases, such as foodborne illnesses (Bacillus cereus, Escherichia coli, Salmonella enterica, and Toxoplasma gondii), skin infections and/or mastitis (Staphylococcus aureus and Streptococcus uberis), malaria (Plasmodium falciparum) and plant infections as "chestnut ink" or "root rot" (Phytophthora cinnamomi). Both extracts showed activity against all the tested species, being nontoxic for the host. So, they could be used for the development of biocides to control a wide range of pathogenic agents and contribute to the enhancement of winemaking industry by-products.

show abstract

“…11,12 Artemisia annua is very poor in catechins and mixing with other plants rich in catechins (moringa, green tea) might have antagonistic effects. 13,14 But many of these plants have prophylactic properties, probably because of this high vitamin C content, like grapefruit juice or papaya. Vitamin C stimulates humoral immunity through increased antibody synthesis particularly IgG, IgA, IgM and also activating the macrophages.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2018

PPIJ

View full text Add to dashboard Cite

Antioxidant and Anti-malarial Properties of Catechins

Cited by 13 publications

References 29 publications

Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents

Natural Phenolic Compounds and Derivatives as Potential Antimalarial Agents

Exploring the powerful phytoarsenal of white grape marc against bacteria and parasites causing significant diseases

Untitled

Contact Info

Product

Resources

About