Antioxidant and antibacterial potential of pomegranate peel extracts

Abstract

Pomegranate peels of Ganesh variety were subjected to extraction using different solvents viz. water, methanol and ethanol either alone or in combination with water. The extraction yield, antioxidant activity (DPPH and ABTS inhibition) and total phenolic contents were evaluated. Highest yield was obtained from 50 % ethanol: 50 % water (16.3 ± 1.99 %). The DPPH and ABTS inhibition activity was found to be the highest for methanol and 70 % ethanol: 30 % water extract (79.5 ± 6.5; 94.6 ± 6.10), respectively. The phenolic content was the highest in the aqueous extract (438.3 ± 14.15). The antibacterial activity of peel extracts was tested against four bacterial strains, Staphylococcus aureus, Enterobacter aerogenes, Salmonella typhi and Klebsiella pneumoniae and the extracts demonstrated remarkable antibacterial activities against all the tested bacterial strains. The 70 % ethanol: 30 % water and 100 % water extract had a higher antioxidant activity and phenolic content and has the potential for nutraceutical application.

Antioxidant, Antimicrobial and Urease Inhibitory Activities of Phenolics-Rich Pomegranate Peel Hydro-Alcoholic Extracts

“…Hydro‐alcoholic extracts of PoP were previously reported to contain substantial concentration of total phenolics and have shown increased antioxidant activity, that is, ∼438 mg/g and 93%, respectively (Malviya et al . ). This study confirms that the indigenous white pomegranate cultivar of Pakistan is a significant source of phenolics and hence could potentially be exploited as potent free radical scavengers in biomedical formulations.…”

“…; Malviya et al . ). Advanced research on PoP and its extracts primarily focuses upon suppression of oxidative stress in tissues and food systems (Bopitiya and Madhujith ; Wang et al .…”

Study on antibacterial and flavonoid content of ethanolic extract of Punica granatum (pomegranate) peel

“…and Klebsiella pneumoniae but concentration at which they are inhibited is not mentioned. 17 Pomegranate peel polyphenols, especially tannins are the major components in the pomegranate peel extract that have been implicated in antimicrobial potential i.e. antiviral, antifungal and antibacterial activities.…”

Punica granatum (pomegranate) leaves extract induces apoptosis through mitochondrial intrinsic pathway and inhibits migration and invasion in non-small cell lung cancer in vitro

“…Scientific researches on it were last for nearly half century, most about antioxidant activity [8,9]. Punica granatum(pomegranate) is commonly known as one of the plants used in traditional herbal Abbreviations: NSCLC, non-small-cell lung cancer; TKIs, tyrosine kinase inhibitors; PLE, Punica granatum (pomegranate) leaves extract; MTT, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazoliumbromide; DMSO, dimethyl sulfoxide; PI, propidium iodide; Rh123, 2-(6-amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester; FBS, fetal bovine serum; FCM, flow cytometry; PBS, phosphatebuffered saline; SD, standard deviation; DCm, mitochondrial transmembrane potential; ROS, reactive oxygen species; DCFH-DA, 2',7 0 -dichlorodihydrofluorescein diacetate; EA, ellagic acid; PC, punicalagin.…”