Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys

Li, Xin; Liu, Jingling; Chang, Qinxiang; Zhou, Ziyun; Han, Ru; Liang, Zongsuo

doi:10.3390/molecules26092417

Cited by 37 publications

(29 citation statements)

References 55 publications

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“…The previous studies reported that H. fomes contains procyanidins and proanthocyanidins, [7] which facilitate insulin secretion from pancreatic β-cells. [50][51][52][53][54][55][56] Procyanidins also promote GLUT4 translocation in the muscle tissue via phosphorylation of AMPK and downstream signalling in ICR mice. [53] Additionally, epicatechin has antioxidant and insulinogenic activity, and it also has insulin-like properties.…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo antihyperglycemic activity of the ethanol extract of Heritiera fomes bark and characterization of pharmacologically active phytomolecules

Ansari

Azam

Seidel

et al. 2022

Journal of Pharmacy and Pharmacology

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Objective This study aimed to demonstrate the mechanistic basis of Heritiera fomes, which has traditionally been used to treat diabetes. Methods Clonal pancreatic β-cells and primary islets were used to measure insulin release. 3T3-L1 cells were used to analyse insulin action, and in vitro systems were used to measure further glucose-lowering activity. In vivo assessment was performed on streptozotocin (STZ)-induced type-2 diabetic rats and reversed-phase-HPLC followed by liquid chromatography mass spectrometry (LC-MS) to detect bioactive molecules. Key findings Ethanol extract of Heritiera fomes (EEHF) significantly increased insulin release with stimulatory effects comparable to 1 µM glucagon-like peptide 1, which were somewhat reduced by diazoxide, verapamil and calcium-free conditions. Insulin release was stimulated by tolbutamide, isobutyl methylxanthine and KCl. EEHF induced membrane depolarization and increased intracellular Ca2+ levels. EEHF enhanced glucose uptake in 3T3L1 cells and decreased protein glycation. EEHF significantly inhibited postprandial hyperglycaemia following sucrose loading and inversely elevated unabsorbed sucrose concentration in the gut. It suppressed glucose absorption during in situ gut perfusion. Furthermore, EEHF improved glucose tolerance, plasma insulin and gut motility, and decreased plasma dipeptidyl peptidase IV activity. Procyanidins, epicatechin and proanthocyanidins were some of the identified bioactive constituents that may involve in β-cell actions. Conclusions This study provides some evidence to support the use of H. fomes as an antidiabetic traditional remedy.

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Section: Discussionmentioning

confidence: 99%

In vitro and in vivo antihyperglycemic activity of the ethanol extract of Heritiera fomes bark and characterization of pharmacologically active phytomolecules

Ansari

Azam

Seidel

et al. 2022

Journal of Pharmacy and Pharmacology

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“…Procyanidins are major found in dark-colored fruits including cherry, grape, pomegranate, and blueberry (Ho et al, 2020). As antioxidant, anticancer, antibacterial, and anti-diabetic, procyanidins attract attention in the field of food and pharmacology (Li et al, 2021;Nawrot-Hadzik et al, 2021) Studies showed that the consumption of procyanidin-rich foods can lower the incidence of inflammatory diseases (Williams et al, 2004). Procyanidins (200-400 mg/kg) can inhibit XO activity and reduce serum uric acid levels in hyperuricemia mice in a dose-dependent manner (Wang et al, 2004).…”

Section: Procyanidinsmentioning

confidence: 99%

Effects and underlying mechanisms of food polyphenols in treating gouty arthritis: A review on nutritional intake and joint health

Zou

Yang

et al. 2022

Journal of Food Biochemistry

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Gouty arthritis, one of the most severe and common forms of arthritis, is characterized by monosodium urate crystal deposition in joints and surrounding tissues. Epidemiological evidence indicates that gouty arthritis incidence is sharply rising globally. Polyphenols are found in many foods and are secondary metabolites in plant foods. The anti-inflammatory and antioxidant effects of food polyphenols have been extensively studied in many inflammatory chronic diseases. Research has suggested that many food polyphenols have excellent anti-gouty arthritis effects. The mechanisms mainly include (a) inhibiting xanthine oxidase activity; (b) reducing the levels of inflammatory cytokines and chemokines; (c) inhibiting the activation of signaling pathways and the NLRP3 inflammasome; and (d) reducing oxidative stress. This paper reviews the research progress and pathogenesis of gouty arthritis and introduces the mechanisms of food polyphenols in treating gouty arthritis, which aims to explore the potential of functional foods in the treatment of gouty arthritis. Practical applicationsThe incidence rate of gouty arthritis has increased sharply worldwide, which has seriously affected people's quality of life. According to the current research progress, food polyphenols alleviate gouty arthritis through anti-inflammatory and antioxidant effects. This paper reviews the research progress and molecular pathogenesis of gouty arthritis and introduces the mechanisms of food-derived polyphenols in the treatment of gouty arthritis, which is helpful to the prevention and treatment of gouty arthritis.

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“…The rhizome, as the medicinal tissue of golden buckwheat, is rich in various medicinal and hygienical components such as flavonoids (catechin and epicatechin), antioxidant phenolic compounds, γaminobutyric acid, and terpenoids (Shao et al, 2005;Wang et al, 2005;Zhang et al, 2016). Among these, flavonoids are some of the most functionally valuable components beneficial to health that are good for gastrointestinal dysfunction; enhance vascular toughness; reduce blood sugar, blood fat, and inflammation; promote tumor inhibition; and improve immunity (Chan, 2003;Li et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Proanthocyanidins are plant polyphenols formed by the condensation of flavane-3-ol monomers such as catechin and epicatechin (Li et al, 2021). They are the last components in flavonoid biosynthesis and essential bioactive components in golden buckwheat.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, more and more research has focused on flavonoids in golden buckwheat in recent years. Li et al (2021) purified proanthocyanidins and analyzed their detailed structure in golden buckwheat rhizome. The contents, antioxidant activity, and antidiabetic activity in golden buckwheat rhizome were higher than those in six other Polygonaceae plants (Li et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Integrated Transcriptomics and Widely Targeted Metabolomics Analyses Provide Insights Into Flavonoid Biosynthesis in the Rhizomes of Golden Buckwheat (Fagopyrum cymosum)

Huang

Wang²,

Tang

et al. 2022

Front. Plant Sci.

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Golden buckwheat (Fagopyrum cymosum) is used in Traditional Chinese Medicine. It has received attention because of the high value of its various medicinal and nutritional metabolites, especially flavonoids (catechin and epicatechin). However, the metabolites and their encoding genes in golden buckwheat have not yet been identified in the global landscape. This study performed transcriptomics and widely targeted metabolomics analyses for the first time on rhizomes of golden buckwheat. As a result, 10,191 differentially expressed genes (DEGs) and 297 differentially regulated metabolites (DRMs) were identified, among which the flavonoid biosynthesis pathway was enriched in both transcriptome and metabolome. The integration analyses of the transcriptome and the metabolome revealed a network related to catechin, in which four metabolites and 14 genes interacted with each other. Subsequently, an SG5 R2R3-MYB transcription factor, named FcMYB1, was identified as a transcriptional activator in catechin biosynthesis, as it was positively correlated to eight flavonoid biosynthesis genes in their expression patterns and was directly bound to the promoters of FcLAR2 and FcF3'H1 by yeast one hybrid analysis. Finally, a flavonoid biosynthesis pathway was proposed in the rhizomes of golden buckwheat, including 13 metabolites, 11 genes encoding 9 enzymes, and 1 MYB transcription factor. The expression of 12 DEGs were validated by qRT-PCR, resulting in a good agreement with the Pearson R ranging from 0.83 to 1. The study provided a comprehensive flavonoid biosynthesis and regulatory network of golden buckwheat.

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Antioxidant and Antidiabetic Activity of Proanthocyanidins from Fagopyrum dibotrys

Cited by 37 publications

References 55 publications

In vitro and in vivo antihyperglycemic activity of the ethanol extract of Heritiera fomes bark and characterization of pharmacologically active phytomolecules

In vitro and in vivo antihyperglycemic activity of the ethanol extract of Heritiera fomes bark and characterization of pharmacologically active phytomolecules

Effects and underlying mechanisms of food polyphenols in treating gouty arthritis: A review on nutritional intake and joint health

Integrated Transcriptomics and Widely Targeted Metabolomics Analyses Provide Insights Into Flavonoid Biosynthesis in the Rhizomes of Golden Buckwheat (Fagopyrum cymosum)

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