Antioxidant and antigenotoxic effects of pupae of the muga silkworm Antheraea assamensis

Deori, Meetali; Boruah, Dulal Chandra; Devi, Dipali; Devi, Rajlakshmi

doi:10.1016/j.fbio.2013.12.001

Cited by 36 publications

(36 citation statements)

References 29 publications

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“…The reducing power of a compound may serve as a significant indicator of its potential antioxidant activity (Pal et al, 2011). Samples with higher reducing power have better abilities to donate the electron and the free radical form stable substances by accepting the donated electrons, resulting in the termination of radical chain reaction (Deori et al, 2014). In our previous report, the polyphenolic compounds of C. asiatica showed significantly reduced the ferric cyanide complex to the ferrous form (reducing capabilities) at higher concentrations (Kumari et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

In vitro and In vivo Antioxidant, Anti-hyperlipidemic Properties and Chemical Characterization of Centella asiatica (L.) Extract

et al. 2016

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The study aimed to identify the phenolic compounds present in Centella asiatica (L.) (C. asiatica) extract and evaluate the respective antioxidant potential as well as its cholesterol-lowering effects in the experimental animal model. Herein, the antioxidant potential of extracts was assessed by its free radical scavenging activity such as 2, 2-diphenyl -1- picrylhydrazyl as well as reducing capability. The anti-hyperlipidemic effects of C. asiatica extract (CAE) were evaluated in high cholesterol-fed (HCF) rats for 4 weeks, where different concentrations of extracts (0.25, 0.5, and 1 g/kg/day) were orally administrated daily. Lipid and antioxidant profiles, including total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and superoxide dismutase (SOD), together with the indices of hepatic functions were also examined. C. asiatica revealed excellent free radical scavenging activity as revealed by 2-2- diphenyl-1-picryl-hydrazyl (DPPH) assay, with the IC50 values (9.62 ± 0.88 μg/mL). Furthermore, C. asiatica extracts and fenofibrate remarkably lowered the level of TC, TG, LDL-C, and showed elevated levels of HDL-C, SOD. The histopathological observations further demonstrated clear differentiation and structural changes in liver of HCF and CAE treated group. Furthermore, gulonic acid, ferulic acid, kaempferol, chlorogenic acid, and asiatic acid were identified to be the major components which might be responsible for the antioxidant activity of the C. asiatica extract as evidenced from an ultra-high performance liquid chromatography–mass spectrometer. Taken together, these results signifies the excellent antioxidant and anti-hyperlipidemic properties of C. asiatica leaf extracts, which might be useful for the treatment of oxidative-stress related diseases such as hyperlipidemia.

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Section: Discussionmentioning

confidence: 99%

In vitro and In vivo Antioxidant, Anti-hyperlipidemic Properties and Chemical Characterization of Centella asiatica (L.) Extract

et al. 2016

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“…So far, researches about silkworm pupae hydrolysates have mostly focused on their biological activities, including the inhibition of adipogenesis, high-fat diet inducing obesity and tyrosinase activity [13]. To date, there is very little information regarding the effect of food processing conditions on the physiological properties of silkworm protein hydrolysates.…”

Section: Introductionmentioning

confidence: 99%

Comparisons of Processing Stability and Antioxidant Activity of the Silkworm Pupae Protein Hydrolysates by Spray-dry and Freeze-dry

Shi

Lin

Xiao

et al. 2017

International Journal of Food Engineering

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Abstract:Silkworm pupae protein (SPP) was pretreated by different processing (heat/alkali/pepsin) and then hydrolyzed by five proteases (trypsin/flavorzyme/papain/protamex/alcalase), respectively. It was found that the combination of heat pretreatment and alkali pretreatment followed by enzymatic hydrolysis with trypsin and flavorzyme could remarkably improve the protein recovery. The hydrolysates obtained from silkworm pupae protein hydrolyzed with trypsin and flavorzyme were stable at the pH range of 4.0-8.0, remaining 95 % of its original reducing power and 90 % of its OH• scavenging activity. However, they were susceptible to alkaline treatments (pH > 10.0) and lost >30 % of their antioxidant activities. Pasteurization (65 °C × 30 min) or autoclaving sterilization (121 °C × 20 min) did not show notable effects on the antioxidant activities. It was concluded that silkworm pupae protein hydrolysates (SPPH) were better to be applied in either neutral or acidic food system rather than in alkaline conditions.

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“…Many studies have conducted research on improving the taste of the silkworm, but none of them have been successful in odor removal. Thus, even though a high amount of silkworm pupa is processed into feed, only a small amount of silkworm is used in food, cosmetics, and healthcare products [31,32]. The development of an economical and environmentally friendly silkworm-based product is, therefore, urgently required.…”

Section: Discussionmentioning

confidence: 99%

Biosafety Evaluation of Three Sodium Lauryl N‐Amino Acids Synthesized from Silk Industrial Waste in Mice

Ding

Wan

Zhang

2017

J Surfact & Detergents

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In this study, three amino acid mixtures recovered from silk industry waste were reacted with lauryl chloride to synthesize three sodium laurel N‐amino acid surfactants. The three types of anionic surfactants are referred to as silk fibroin surfactant, silk sericin surfactant, and silkworm pupae surfactant. All three surfactants showed good surface properties. To evaluate biological safety, we added these three surfactants to the normal diet of mice for 8 weeks. Blood indices, blood lipid, antioxidant capacity (GSH‐PX, MDA, T‐AOC, and T‐SOD), and lipid metabolism key enzyme mRNA (PPAR‐γ, SREBP, FASN, and C/EBP‐α) levels in the liver were measured. No evident histopathological changes were found in the liver and kidney. The results showed no significant difference in their indexes between the surfactant‐fed and normal diet‐fed mice. Thus, the three amino acid surfactants are biologically safe and can be used in daily chemical cleaning products. These surfactants will not only help to reduce wastage of resources and damage to the environment, but also yield economic benefits to the silk industry in the future.

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Antioxidant and antigenotoxic effects of pupae of the muga silkworm Antheraea assamensis

Cited by 36 publications

References 29 publications

In vitro and In vivo Antioxidant, Anti-hyperlipidemic Properties and Chemical Characterization of Centella asiatica (L.) Extract

In vitro and In vivo Antioxidant, Anti-hyperlipidemic Properties and Chemical Characterization of Centella asiatica (L.) Extract

Comparisons of Processing Stability and Antioxidant Activity of the Silkworm Pupae Protein Hydrolysates by Spray-dry and Freeze-dry

Biosafety Evaluation of Three Sodium Lauryl N‐Amino Acids Synthesized from Silk Industrial Waste in Mice

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