Antioxidant and free radical scavenging activities of wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) in Taiwan

Wu, Shu-Jing; Ng, Lean‐Teik

doi:10.1016/j.lwt.2007.03.003

Cited by 210 publications

(164 citation statements)

References 35 publications

Supporting

Mentioning

149

Contrasting

Unclassified

Order By: Relevance

“…Thus, there is a need to develop compounds with xanthine oxidase inhibitory activities but devoid of the undesirable effects of allopurinol. Recently, natural product and food derived antioxidants such as vitamins and phenolic phytochemicals have received growing attention, because they are known to function as chemopreventive agents against oxidative damage [13] . There is abundant evidence that a great number of aromatic, spicy, medicinal and other plants contain chemical compounds exhibiting antioxidant properties.…”

Section: Extraction Of Phenolic Compoundsmentioning

confidence: 99%

Antioxidants, Free Radicals Scavenging and Xanthine Oxidase Inhibitory Potentials of Ajuga iva L. Extracts.

Baghiani

Boumerfeg²,

Adjadj

et al. 2011

Free Radicals and Antioxidants

View full text Add to dashboard Cite

Section: Extraction Of Phenolic Compoundsmentioning

confidence: 99%

Antioxidants, Free Radicals Scavenging and Xanthine Oxidase Inhibitory Potentials of Ajuga iva L. Extracts.

Baghiani

Boumerfeg²,

Adjadj

et al. 2011

Free Radicals and Antioxidants

View full text Add to dashboard Cite

“…rantia, Wu and Ng, (2008) obtained similar results for DPPH assay of wild M. charantia fruits extracts in EtOH (IC 50 = 157 g/mL) exceeding vitamin E activity (IC 50 = 172 g/mL). Nevertheless, it was weak in TBARS assay.…”

Section: Antioxidant Activitymentioning

confidence: 55%

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

Svobodová

Barros

Calhelha

et al. 2017

Industrial Crops and Products

View full text Add to dashboard Cite

a b s t r a c tA wild variety of bitter melon Momordica charantia L. (Cucurbitaceae) has been used in bush medicine of Trinidad and Tobago for treatment of diabetes, inflammations and cancer. Despite many studies regarding the cultivated bitter melon, the wild variety has been poorly investigated. This study evaluates the biological activities of the ethanol/water extract of aerial parts and correlates these activities with the presence of phenolic compounds. The extract exhibited antioxidant activity in the four assays (DPPH, reducing power, ␤-carotene bleaching and TBARS). The key role of oxidative stress in inflammation and tumorigenesis was supported by the results of anti-inflammatory (inhibition of nitric oxide production) and cytotoxicity (human tumor cell lines, namely HeLa, HepG2, MCF-7, and NCI-H460) assays. In contrast, no toxicity was observed in non-tumor cells. In the antibacterial screening, clinical resistant isolates were significantly affected (MIC 50 = 10-0.625 g/mL), being Listeria monocytogenes the most susceptible. Three phenolic acids and eleven flavonol glycosides derivatives were identified, quercetin-3-O-pentosylhexoside being the most abundant.

show abstract

“…Furthermore, it is well known that polyphenols have various pharmacological properties, including hypolipidemic and antiatherogenic activity [43]. The tannins and flavones may perform in free radical scavenging mechanism and may check atherogenesis in rabbit aorta [44,45].…”

Section: Discussionmentioning

confidence: 99%

Anti-Atherosclerotic Activity of Elaeocarpus Ganitrus Roxb. In Cholesterol-Fed Rabbits

Jain

Joshi

2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objectives: Atherosclerosis was experimentally induced in New Zealand white male rabbits by cholesterol feeding for 120 days for investigating effects of 70% ethanolic Elaeocarpus ganitrus seed extract (EEGS) against atherosclerosis.Methods: Anti-atherosclerotic activity of E. ganitrus extract was evaluated at a dose level of 250 and 500 mg/kg of body weight (p.o). On 121 st day, the animals were sacrificed to collect the aorta for determining tissue lipid profile, antioxidant parameters, and histopathological changes. One-way ANOVA followed by Tukey's multiple comparison test was used for the statistical analysis.Results: Aorta of cholesterol-fed rabbits for 120 days showed marked elevation in total cholesterol, triglycerides, and phospholipids. EEGS extract treatment significantly (p≤0.01, ≤0.001) corrected disturbed lipid profile in cholesterol-fed rabbits in a dose-dependent manner during the 60 days of the treatment period. A significant reduction in lipid peroxidation and a considerable raise in glutathione, catalase, and superoxide dismutase levels (p≤0.01, ≤0.001) were accompanied by post-treatment with EEGS extract to cholesterol-fed rabbits. The histopathological modifications such as accumulation of foam cells, atheromatous plaque formation, and lumen size reduction supported the successful induction of atherosclerosis in rabbits. The treated rabbits showed significant protective effect by lowering the deposition of cholesterol and increasing the lumen size compared to cholesterol-fed group.Conclusions: Phytoconstituents such as alkaloids, tannins, flavonoids, steroids, triterpenoids, and carbohydrates in the ethanolic extract may be attributed to effective anti-atherosclerotic and antioxidant activity of plant extract. Our study exhibited that EEGS extract could be a potent herbal therapeutic agent for the treatment of atherosclerosis and hypercholesterolemia-related diseases.

show abstract

Antioxidant and free radical scavenging activities of wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) in Taiwan

Cited by 210 publications

References 35 publications

Antioxidants, Free Radicals Scavenging and Xanthine Oxidase Inhibitory Potentials of Ajuga iva L. Extracts.

Antioxidants, Free Radicals Scavenging and Xanthine Oxidase Inhibitory Potentials of Ajuga iva L. Extracts.

Bioactive properties and phenolic profile of Momordica charantia L. medicinal plant growing wild in Trinidad and Tobago

Anti-Atherosclerotic Activity of Elaeocarpus Ganitrus Roxb. In Cholesterol-Fed Rabbits

Contact Info

Product

Resources

About