Antioxidant and pro-oxidant effects of tannins in digestive cells of the freshwater mussel Unio tumidus

Łabieniec, Magdalena; Gabryelak, Teresa; Falcioni, Giancarlo

doi:10.1016/s1383-5718(03)00115-3

Cited by 103 publications

(64 citation statements)

References 40 publications

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“…In addition, according to Calvo et al (2007) This chemical composition can explain the mutagenicity of the extracts detected by the Ames Assay. Several studies have shown that phenolic compounds can damage DNA (Jurado et al, 1991;Gaspar et al, 1993;Labieniec et al, 2003). According to Cardoso et al (2006), the aglycone quercetin and amentoflavone were mutagenic to strain TA98, with and without metabolic activation.…”

Section: Discussionmentioning

confidence: 99%

Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test

Santos¹,

Calvo²,

Cólus³

et al. 2010

Rev. bras. farmacogn.

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Some species of the plant genus Alchornea (family Euphorbiaceae) are widely used in popular medicine, mainly in South America and in Africa. Several kinds of biological activity have been seen in the species: antioxidant, antifungal, anti-inflammatory, antibacterial, cytotoxic against tumor cell lines and inhibitory to the replication of HIV-1 and HIV-2. In Brazil, the species Alchornea castaneaefolia Willd. A. Juss. and Alchornea glandulosa Poepp. & Endl. are used by the local population to treat rheumatism, arthritis and muscular pains. In view of the popular use of these plants as medicines and the potential risks from their consumption, we assessed the mutagenic potential of chloroform and methanol extracts of the leaves of these plant species, employing the in vivo micronucleus test and the Ames assay. The data obtained showed that the chloroform extracts were not mutagenic. The methanol extract of A. castaneaefolia was mutagenic to strain TA98 of Salmonella typhimurium and the methanol extract of A. glandulosa to strains TA98 and TA97a. The methanol extracts of both species of Alchornea were mutagenic in vivo at the largest dose employed. The probable mutagenic agents involved were the aglycone quercetin and amentoflavone, present in both species.

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Section: Discussionmentioning

confidence: 99%

Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test

Santos¹,

Calvo²,

Cólus³

et al. 2010

Rev. bras. farmacogn.

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“…The mechanisms by which they exert their antioxidant action resulting from a combination of chelating properties of transition metals and sequestering free radicals and the inhibition of oxidases and other enzymes action. However, these compounds can act as pro-oxidants, feature probably responsible for the mutagenicity and genotoxicity, also found for some of these metabolites in prokariotic and eukariotic cells in vivo systems (Walle et al, 2001;Labiniec et al, 2003). Some of the mechanisms through which they exert their pro-oxidant actions include copper reduction, generation of reactive oxygen species (ROS) and participation antioxidant nuclear defense system: Glutathione and glutathione-S-transferase (Pérez Trueba et al, 2003).…”

Section: Resultsmentioning

confidence: 99%

“…Some of the mechanisms through which they exert their pro-oxidant actions include copper reduction, generation of reactive oxygen species (ROS) and participation antioxidant nuclear defense system: Glutathione and glutathione-S-transferase (Pérez Trueba et al, 2003). Probably the cause of mutagenic effects observed in the comet assay after exposure to genotoxic extracts, is the formation of ROS associated with the presence of flavonoids (Labiniec et al, 2003) where molecules of phenolic acids bind with proteins and lipids, and they are oxidized by O 2 , O 2 -or H 2 O 2 . Bors et al (1999) attributes the DNA damage free radicals generated oxygen during the reactions between protein-polyphenol complex and oxygen.…”

Section: Resultsmentioning

confidence: 99%

Comet assay application in evaluation the safe use of medicinal plants

Mohamed¹,

Cangiano²,

Alcaráz³

et al. 2016

Emir. J. Food Agric

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“…In addition, they may also have antimutagenic and antitumor effects (Dauer et al, 2003). However, these polyphenols, similar to the flavonoids, have pro-oxidant effects in the presence of metal ions and can thereby act as cytotoxins and genotoxins (Labieniec et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of genotoxic and cytotoxic effects of antileishmanial extract from Julocroton triqueter (Euphorbiaceae)

Moreira¹,

Dias²,

Martins³

et al. 2013

Genet. Mol. Res.

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ABSTRACT.Julocroton triqueter extracts have antileishmanial activity; however, the effect on genetic stability has not been studied. We evaluated genotoxic and cell death induction potential (in vitro and in vivo) of J. triqueter var. triqueter hydroalcoholic extracts, as well as their antigenotoxic potential in vivo. The in vitro genotoxic studies were performed using human leukocytes at four different concentrations. For the in vivo tests, Swiss mice were treated with 125, 250 or 500 mg/kg of extract injected intraperitoneally. Antigenotoxic effects of the extract were measured before and after cyclophosphamide treatment. An absence of genotoxic effects was observed both in vitro and in vivo. In the antigenotoxic studies, no significant difference was observed between the treatments and the positive control, indicating that the extracts did not protect against Evaluation of genotoxic effects of antileishmanial extract damage caused by cyclophosphamide. Hydroalcoholic extracts of J. triqueter did not provoke DNA damage at concentrations and doses normally used for antileishmanial treatment; however, they reduced apoptotic cell death and induced necrotic cell death.

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Antioxidant and pro-oxidant effects of tannins in digestive cells of the freshwater mussel Unio tumidus

Cited by 103 publications

References 40 publications

Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test

Mutagenicity of two species of the genus Alchornea measured by Salmonella microsome assay and micronucleus test

Comet assay application in evaluation the safe use of medicinal plants

Evaluation of genotoxic and cytotoxic effects of antileishmanial extract from Julocroton triqueter (Euphorbiaceae)

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