Antioxidant and prooxidant properties of flavonoids

Procházková, Dagmar; Boušová, Iva; Wilhelmová, N.

doi:10.1016/j.fitote.2011.01.018

Cited by 1,272 publications

(858 citation statements)

References 139 publications

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“…Anticarcinogenic and antioxidant properties of xanthohumol present in Humulus lupulus L. have been reported before (3,5,(9)(10)(11)(12)(13)(14)(37)(38)(39). However, scarce information is available on the eff ect of xanthohumol on yeast cells.…”

Section: Discussionmentioning

confidence: 99%

Dose-Dependent Protective and Inductive Effects of Xanthohumol on Oxidative DNA Damage in Saccharomyces cerevisiae

Carvalho

Oliveira

Johansson

et al. 2016

Food Technol. Biotechnol.

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SummaryThe eff ect of xanthohumol, a prenylfl avonoid isolated from the hop plant (Humulus lupulus L.), on Saccharomyces cerevisiae DNA oxidative damage and viability was evaluated. Yeast cultures under oxidative stress, induced by H 2 O 2 , displayed stronger growth in the presence of 5 mg/L of xanthohumol than cultures with only H 2 O 2 . Likewise, DNA damage assessed by the comet assay was signifi cantly lower in cells co-incubated with xanthohumol and H 2 O 2 . Accordingly, fl uorescence of dichlorofl uorescein in cells treated with H 2 O 2 and xanthohumol was considerably lower than in cells exclusively treated with H 2 O 2 , indicative of a reactive oxygen species scavenging mechanism and consequent formation of oxidation products, as detected by mass spectrometry. However, at concentrations above 5 mg/L, xanthohumol elicited an opposite eff ect, leading to a slower growth rate and significant increase in DNA damage. A yeast yap1 deletion mutant strain sensitive to oxidative stress grew more slowly in the presence of at least 5 mg/L of xanthohumol than cultures of the wild type, suggesting that xanthohumol toxicity is mediated by oxidative stress. This evidence provides further insight into the impact of xanthohumol on yeast cells, supporting dose-dependent antioxidant/antigenotoxic and prooxidant/genotoxic eff ects.

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Section: Discussionmentioning

confidence: 99%

Dose-Dependent Protective and Inductive Effects of Xanthohumol on Oxidative DNA Damage in Saccharomyces cerevisiae

Carvalho

Oliveira

Johansson

et al. 2016

Food Technol. Biotechnol.

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“…Citrus flavonoids, in particular, are recognized as antioxidants (Procházková et al 2011;Yu et al 2014;Asikin et al 2015), antifungals (Buer et al 2010), antimicrobials (Vikram et al 2010;Cushnie and Lamb 2011;Céliz et al 2011), and even accelerating wound and disease healing (Neves et al Neves et al 2010;Arab and Liebeskind 2010;Codoñer-Franch and Valls-Bellés 2010;Wang et al 2014). In plants, flavonoids appear to play defensive roles against pathogens, including bacteria, fungi and viruses; these are generally found in glycosylated forms in plants, and the sugar moiety is an important factor determining their bioavailability (Agati et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic content and bactericidal effect of Mexican Citrus limetta and Citrus reticulata

et al. 2017

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In this study, total phenolics, total flavonoids, hesperidin and ascorbic acid contents in bagasse, juice and seed of mexican sweet lime (Citrus limetta) and mandarine (Citrus reticulata) were determined at two commercial maturity stages (maturation index), as well as their bactericidal effect on Escherichia coli and Staphylococcus aureus. The results showed that bagasses had the highest total phenolics, total flavonoids, and hesperidin content for both, C. limetta, and C. reticulata; highest ascorbic acid contents were found in C. limetta juice (3.36 ± 0.25 mg g -1 DW) and C. reticulata bagasse (3.83 ± 0.37 mg g -1 DW). All tested extracts showed bacterial growth inhibition at 50 and 800 lg mL -1 . Bagasse extracts of both fruits showed the highest inhibitions ([90%) on tested bacteria. Total phenolics, total flavonoids, and hesperidin contents, as well as bactericidal effect increased with maturity. Results indicated that both Mexican citric fruits (C. limetta and C. reticulata) were good sources of antioxidant and bactericidal agents.

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“…O seu potencial para atuar como agentes anti-tumorigênicos e anti-proliferativos tem sido relatado, além de ter propriedades antiviral, antifúngica, antibacteriana, vasodilatador, anticancerígeno e anti-isquêmico (32)(33)(34).…”

Section: Resultsunclassified

“…Determinação da atividade antioxidante pelo método DPPH. As propriedades antioxidantes dos compostos fenólicos têm sido atribuídas à sua capacidade de sequestrar radicais livres gerados na fase aquosa e aumentar a resistência dos lipídeos contra a peroxidação (34). A porcentagem de inibição indica qual é a capacidade das amostras e padrões em sequestrar o radical livre DPPH, sendo que aqueles que produzem um maior percentual de inibição são os mais eficientes (42).…”

Section: Resultsunclassified

PERFIL FITOQUÍMICO, SUSCEPTIBILIDADE ANTIBACTERIANA E CAPACIDADE ANTIOXIDANTE DAS FOLHAS DE Croton urucurana Baillon (Euphorbiaceae)

Silva

Alves²,

Sousa³

et al. 2017

Infarma

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Croton urucurana Baillon, popularly known as "sangria d'água", belongs to the Euphorbiaceae family. The species has a great importance in folk medicine as antibacterial, anti-inflammatory, antiseptic, antiviral, antidiarrheal, intestinal antisecretory and cicatrizant remedies. The objective of this study was to verify the presence, in the aqueous, ethanolic and hydroalcoholic extracts, of secondary metabolites (alkaloids, anthraquinones, steroids/triterpenoids, flavonoids, glycosides, saponins and tannins), analyze the inhibition of bacteria Staphylococcus aureus ATCC 25923 and Salmonella thyphimurium ATCC 14028 growth, and evaluate the antioxidant activity by the DPPH method. Considering the phytochemical profile, the best extract was the aqueous; the bacteria susceptibility was inhibited with the ethanolic extract; and the extract with the highest antioxidant activity was the hydroalcoholic, presenting IC 50 1.3 μg/ mL. It was concluded that the extracts of Croton urucurana Baillon show interesting results and that further investigations must be carried out for the better elucidation of its benefits. Keywords:Croton urucurana Baillon; phytochemical; antioxidant; antibacterial; extract. RESUMOCroton urucurana Baillon, espécie conhecida popularmente como "sangria d'água", pertence à família Euphorbiaceae, possui grande importância na medicina popular, a qual lhe atribui propriedades antibacterianas, anti-inflamató-rias, antissépticas, antivirais, antidiarreicas, antissecretória intestinal e cicatrizante. Os objetivos deste estudo foram verificar a presença, nos extratos aquoso, etanólico e hidroalcoólico, de metabolitos secundários (alcaloides, antraquinonas, esteroides/triterpenoides, flavonoides, glicosídeos, saponinas e taninos), analisar a inibição do crescimento das bactérias Staphylococcus aureus ATCC 25923 e Salmonella thyphimurium ATCC 14028, e verificar a atividade antioxidante através do método DPPH. Para o perfil fitoquímico o melhor extrato foi o aquoso, quanto à susceptibilidade bacteriana, houve inibição com o extrato etanólico e o extrato com a maior atividade antioxidante foi o hidroalcóolico, apresentando IC 50 1,3 μg/mL. Considerando os resultados obtidos no estudo, foi possível concluir que os extratos da Croton urucurana Baillon apresentam resultados interessantes e que mais investigações devem ser realizadas para a elucidação aprimorada dos seus benefícios.

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Antioxidant and prooxidant properties of flavonoids

Cited by 1,272 publications

References 139 publications

Dose-Dependent Protective and Inductive Effects of Xanthohumol on Oxidative DNA Damage in Saccharomyces cerevisiae

Dose-Dependent Protective and Inductive Effects of Xanthohumol on Oxidative DNA Damage in Saccharomyces cerevisiae

Polyphenolic content and bactericidal effect of Mexican Citrus limetta and Citrus reticulata

PERFIL FITOQUÍMICO, SUSCEPTIBILIDADE ANTIBACTERIANA E CAPACIDADE ANTIOXIDANTE DAS FOLHAS DE Croton urucurana Baillon (Euphorbiaceae)

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