Antioxidant, anti-inflammatory and anticarcinogenic activities of edible red oak (Quercus spp.) infusions in rat colon carcinogenesis induced by 1,2-dimethylhydrazine

Moreno‐Jiménez, Martha Rocío; Trujillo-Esquivel, Fátima; Gallegos‐Corona, Marco A.; Reynoso‐Camacho, Rosalía; González‐Laredo, Rubén Francisco; Gallegos‐Infante, José Alberto; Rocha‐Guzmán, Nuria Elizabeth; Ramos-Gómez, Minerva

doi:10.1016/j.fct.2015.03.011

Cited by 38 publications

(17 citation statements)

References 59 publications

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“…IL-10 is not only produced by various immunocompetent cells but also by human cell lines derived from carcinomas such as colon, kidney, and breast. Although IL-10 is an anti-inflammatory cytokine and exhibits various immunosuppressive effects in vivo , it has been demonstrated that some colon cancer cells (for example, HT-29) can produce IL-10 themselves, resulting in tumors escaping the immune system’s defenses 39 , 40 . Interestingly, our results indicated that KJT has the potential to reduce IL-10 levels in rats, thus suggesting a lower capacity to escape the immune system.…”

Section: Discussionmentioning

confidence: 99%

Chemopreventive effects of Ku-jin tea against AOM-induced precancerous colorectal lesions in rats and metabolomic analysis

Shen

et al. 2017

Sci Rep

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Ku-jin tea (KJT) is a health beverage prepared from the leaves of the plant Acer tataricum subsp. ginnala that has been consumed in some regions of China for thousands of years. KJT contains high levels of anti-inflammatory and antioxidative compounds such as ginnalins, but little is known about the chemopreventive effect of KJT on colon cancer. In this study, we investigated the preventive effects of KJT on colon carcinogenesis using the azoxymethane (AOM)-induced precancerous colorectal lesion model in rats. The results showed that the number of aberrant crypts, aberrant crypt foci (ACF) and crypts/focus in rats of the KJT + AOM group were significantly decreased compared with rats of the AOM group (p < 0.01). Further exploration of the prevention mechanism of KJT by UPLC-QTOF/MS-based urinary metabolomics showed that 5 metabolic pathways were modulated, including purine metabolism and amino acid metabolism, in the group with KJT. In addition, the levels of the immunomodulatory cytokines IL-1α and IL-10 were significantly decreased, and the levels of IL-2 in the serum of AOM rats increased after KJT treatment. Our present data suggest that KJT can inhibit AOM-induced colonic ACF formation and might be a useful chemopreventive agent against colorectal carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Chemopreventive effects of Ku-jin tea against AOM-induced precancerous colorectal lesions in rats and metabolomic analysis

Shen

et al. 2017

Sci Rep

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“…In recent years, interest in and consumption of infusions from acorn leaves have considerably increased in Mexico [ 12 ], and methods for the nanoencapsulation of tea from acorn leaves have been developed [ 13 ]. Many studies have reported about the total polyphenol, flavonoid, and proanthocyanidin content of acorn leaves [ 14 , 15 ], and chromatographic methods have been used to determine specific groups [ 16 , 17 ]. To the best of our knowledge, the active compounds and potential pharmacologic properties of acorn leaves remain unclear to date.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols from Acorn Leaves (Quercus liaotungensis) Protect Pancreatic Beta Cells and Their Inhibitory Activity against α-Glucosidase and Protein Tyrosine Phosphatase 1B

Wang

Yue

et al. 2018

Molecules

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Acorn leaves, which possess potential pharmacologic effects, are traditionally consumed as food in China. Phytochemical investigations of acorn leaves yielded one new and 25 known polyphenols, and their structures were identified by extensive spectroscopic analysis. Three antidiabetes assays were conducted. Compound 2 considerably increased the survival of pancreatic beta cells by reducing the production of reactive oxygen species and enhancing the activities of superoxide dismutase, catalase, and glutathione in MIN6 cells damaged by H2O2. The preliminary mechanism by which compound 2 protects pancreatic beta cells was through the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 HO-1 pathway. Most of the tested isolates showed strong inhibitory activity against α-glucosidase and protein tyrosine phosphatase 1B. The IC50 values of most compounds were much lower than those of the positive control. The results suggest that polyphenols from acorn leaves are potential functional food ingredients that can be used as antidiabetic agents.

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“…In China, they are mainly found in Heilongjiang, Jilin and Liaoning [1]. It has been reported that extracts of leaves, acorns or woods from oak trees possessed numerous kinds of biological activities, including antioxidant, anti-inflammatory, anticarcinogenic, antidiabetic and antimicrobial [9][10][11]. Moreover, our two previous reports showed that phenolic extracts of oak cups were rich in phenolics (mainly ellagic acid, kaempferol and their derivatives), with high antioxidant and antidiabetic activities in vitro [1,12].…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic Effects in Alloxan-Induced Diabetic Rats of the Phenolic Extract Enriching Ellagic Acid, Kaempferol and Their Derivatives from Mongolian Oak Cups

Yin¹,

Wang²,

Yang³

et al. 2018

Preprint

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Our previous in vitro reports showed that crude extract prepared with 50% ethanol (ethanol crude extract, ECE) from Mongolian oak cups possessed excellent antioxidant capacities as well as inhibitory activities against α-glucosidase, α-amylase and protein glycation caused by its enrichment in phenolics, including mainly ellagic acid, kaempferol and their derivatives. Nevertheless, few in vivo studies on antidiabetic activities of these phenolics were conducted. The present study investigated hypoglycemic effects with normal and diabetic rats being administrated orally without or with ECE at 200 and 800 mg/kg for 15 days. In normal rats, no significant differences were exhibited after ECE administration in body weight, fasting blood glucose level, levels of chelesterol, triglyceride, LDL and AST in serum, organ indexes, and levels of GSH and MDA in organs. In diabetic rats, the fasting blood glucose level, indexes of heart and liver, and levels of chelesterol and triglyceride in serum and MDA in heart tissue were significantly decreased. Moreover, HDL levels in serum and SOD activities in the four organs of diabetic rats were significantly improved after ECE administration at 800 mg/kg. Thus, in addition to inhibiting α-glucosidase, α-amylase and protein glycation reported previously, oak cups might contain novel dietary phytonutrients in preventing abnormal changes in blood glucose and lipid profile and attenuating oxidant stress in vivo. The results also implied that it is ellagic acid, kaempferol and their derivatives enriched in ECE that might play vital roles in managing type 1 as well as type 2 diabetes.

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Antioxidant, anti-inflammatory and anticarcinogenic activities of edible red oak (Quercus spp.) infusions in rat colon carcinogenesis induced by 1,2-dimethylhydrazine

Cited by 38 publications

References 59 publications

Chemopreventive effects of Ku-jin tea against AOM-induced precancerous colorectal lesions in rats and metabolomic analysis

Chemopreventive effects of Ku-jin tea against AOM-induced precancerous colorectal lesions in rats and metabolomic analysis

Polyphenols from Acorn Leaves (Quercus liaotungensis) Protect Pancreatic Beta Cells and Their Inhibitory Activity against α-Glucosidase and Protein Tyrosine Phosphatase 1B

Hypoglycemic Effects in Alloxan-Induced Diabetic Rats of the Phenolic Extract Enriching Ellagic Acid, Kaempferol and Their Derivatives from Mongolian Oak Cups

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