Antioxidant Effect of Channa Micropeltes in Diabetic Wound of Oral Mucosa

Apriasari, Maharani Laillyza; Ainah, Yusfa; Febrianty, Eka; Carabelly, Amy Nindia

doi:10.3923/ijp.2019.137.143

Cited by 10 publications

(15 citation statements)

References 14 publications

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“…Albumin is known able to activate the signaling of nuclear factor erythroid2related (Nrf2) for antioxidant and other enzymes, including heme oxygenase-1 (HO-1). 45 Activation of HO-1 eventually promotes the anti-inflammatory activity by inducing the expression of anti-inflammatory cytokines IL-10 and IL-4. [46][47] Albumin possibly suppressed the production of TGF-β in type 1 diabetic mice through ROS levels reduction.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory Effects of Formulation of Channa micropeltes and Moringa oleifera through Anti-Inflammatory Cytokines Regulation in Type 1 Diabetic Mice

et al. 2020

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Background: Diabetes mellitus type 1 (T1DM) is an autoimmune disease characterized by chronic inflammation of the β-pancreas cells. The immunomodulatory activities related to the role of anti-inflammatory cytokines might contribute to control the inflammatory response in T1DM. This study aimed to evaluate the immunomodulatory effect of Moringa oleifera-Channa micropeltes formulation (MC) based on the profile of CD4 + IL-4 + , CD4 + IL-10 + , and CD4 + TGF-β + in type 1 diabetic mice. Methods: A total of 30 mice were divided into six equal groups as normal, diabetic mice, diabetic mice with metformin administration, and diabetic mice with MC administration doses 1, 2 , and 3. The mice were injected intraperitoneally by 145 mg/ kg BW Streptozotocin (STZ) to induce T1DM. Diabetic mice were orally administrated by MC for 14 days. The levels of CD4 + IL-4 + , CD4 + IL-10 + , and CD4 + TGF-β + were determined by flow cytometry analysis. Results: The DM group had low levels of IL-4 and IL-10, but high levels of TGF-β as compared to the normal. Administration of MC in certain doses significantly increased the levels of IL-4 and IL-10, while inversely decreased the levels of TGF-β in diabetic mice at the levels close to the normal and significantly different from the DM group. The glucose levels in diabetic mice after MC administration were significantly lower than the DM group. Conclusion:Based on the results, MC administration in a dosage-dependent manner might have the immunomodulatory effect to reduce the inflammation by increasing IL-4 and IL-10 and suppressing TGF-β in type 1 diabetic mice.

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Section: Discussionmentioning

confidence: 99%

Immunomodulatory Effects of Formulation of Channa micropeltes and Moringa oleifera through Anti-Inflammatory Cytokines Regulation in Type 1 Diabetic Mice

et al. 2020

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“…Albumin in Ifalmin® is known to activate Nrf2 signaling for gene expression of endogenous antioxidant enzymes, including superoxide dismutase (SOD), heme oxygenase-1 (HO-1), glutathione S-transferase, and glutathione peroxidase [34]. Some studies demonstrated that antioxidant enzymes were decreased in DM conditions [35,36].…”

Section: Issn 2087-2852 E-issn 2338-1655mentioning

confidence: 99%

The Role of Moringa oleifera- Ifalmin® Formulation in Regulation of B220+IgM+ and B220+IgG+ in Diabetic Mice

Adharini

Nilamsari

Lestari

et al. 2020

JELS

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It has been known that the immunoglobulin levels were altered in diabetes mellitus (DM) conditions. This study aimed to evaluate the levels of immunoglobulins in DM mice after the administration of Moringa oleifera-Ifalmin® formulation (MI). Streptozotocin, at a dose of 145 mg.kg-1, was injected intraperitoneally to experimental mice to obtain diabetic mice. The groups were divided into normal mice, diabetic mice without treatment, diabetic mice with metformin treatment (307.5 mg.kg-1 BW), and diabetic mice with MI treatment at dose 1 (M:I= 800 mg.kg-1 BW: 800 mg.kg-1 BW), dose 2 (M:I= 615 mg.kg-1 BW: 615 mg.kg-1 BW), and dose 3 (M:I= 800 mg.kg-1 BW: 615 mg.kg-1 BW). Mice were orally treated by MI for 14 days. Subsequently, the levels of immunoglobulin IgM and IgG were evaluated using flow cytometry analysis. IgM and IgG levels were significantly lower in the DM group than the normal group. These results indicated that DM altered immunoglobulin levels. MI treatment for 14 days significantly increased the number of IgM and IgG at the level equivalent to the normal group and significantly different as compared to the DM group. Based on the results, MI can be used as an immunomodulatory agent in humoral immunity through the precise regulation of IgM and IgG.

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“…DM is also notable as an inflammatory disease in which the production of reactive oxygen species (ROS) is intensified. 3,4 An increase of ROS in the inflammatory stage of the diabetic healing process will lead to inevitable results such as a prolonged healing process in the oral mucosa. 4,5 Pathological symptoms in the soft tissues, including; a reduction in salivary flow, xerostomia and taste disorders may often be identified in patients suffering from DM.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 An increase of ROS in the inflammatory stage of the diabetic healing process will lead to inevitable results such as a prolonged healing process in the oral mucosa. 4,5 Pathological symptoms in the soft tissues, including; a reduction in salivary flow, xerostomia and taste disorders may often be identified in patients suffering from DM. Mucosal lesions resulting from fungal infection (oral candidiasis and angular cheilitis), bacterial infection (gingivitis and periodontitis), viral infection (herpes labialis and herpes zoster) and other lesions (oral lichen planus, lichenoid reaction, recurrent aphthous stomatitis) can also frequently be observed.…”

Section: Introductionmentioning

confidence: 99%

The management of herpes labialis, oral thrush and angular cheilitis in cases of oral diabetes

Apriasari

2019

Dent. J.

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Background: As reported in several studies, prolonged or uncontrolled cases of diabetes mellitus (DM) may induce a more extreme inflammatory response. Mucosal lesions can be observed in patients who present this systemic condition. Purpose: The purpose of this study was to elaborate the management of herpes labialis, oral thrush and angular cheilitis as oral manifestations of diabetes. Case: A 49-year-old male complained of having experienced painful lip ulceration for the preceding seven days. The anamnesis of the patient revealed that, prior to lip ulceration, he had experienced high fever and malaise in addition to frequent urination at night and a tingling sensation in the toes and fingertips on waking. Case management: The patient was referred to undergo blood count, fasting blood glucose and oral glucose tolerance tests. The blood test result confirmed the patient to be suffering from DM and anemia. The immunocompromised condition of the patient prompted the occurrence of herpes labialis, oral thrush and angular cheilitis. Conclusion: Multidisciplinary treatment for herpes labialis resulting in oral candidiasis in DM patients is indispensable. Concurrent infection with HSV and candidiasis necessitates a more prolonged healing process. Consequently, it is a essential to treat the hyperglycemia which induces an immunocompromised state in diabetic patients.

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Antioxidant Effect of Channa Micropeltes in Diabetic Wound of Oral Mucosa

Cited by 10 publications

References 14 publications

Immunomodulatory Effects of Formulation of Channa micropeltes and Moringa oleifera through Anti-Inflammatory Cytokines Regulation in Type 1 Diabetic Mice

Immunomodulatory Effects of Formulation of Channa micropeltes and Moringa oleifera through Anti-Inflammatory Cytokines Regulation in Type 1 Diabetic Mice

The Role of Moringa oleifera- Ifalmin® Formulation in Regulation of B220+IgM+ and B220+IgG+ in Diabetic Mice

The management of herpes labialis, oral thrush and angular cheilitis in cases of oral diabetes

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