Antioxidant effects of gliclazide, glibenclamide, and metformin in patients with type 2 diabetes mellitus

Signorini, A. M.; Fondelli, Cecilia; Renzoni, Elisabetta A.; Puccetti, C.; G, Gragnoli; Giorgi, Giorgio

doi:10.1016/s0011-393x(02)80047-9

Cited by 34 publications

(23 citation statements)

References 31 publications

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“…Insulin was reported for its antioxidant effect as it suppressed LDL oxidation when given to T2DM patients [46]. Sulfonylureas have also been reported for its antioxidant effect, but this was demonstrated for gliclazide only [34,47] not all members of sulfonylurea group of compounds. Fortunately, most of patients in the present study were on gliclazide treatment which may account for unchanged ox-LDL levels in these patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of glycemic control on soluble RAGE and oxidative stress in type 2 diabetic patients

et al. 2013

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BackgroundThe interaction of advanced glycation end products (AGEs) and its receptor (RAGE) has played an important role in the pathogenesis of diabetes and its complications. A soluble form of RAGE (sRAGE) has been reported as a decoy receptor for AGEs. Oxidative stress is demonstrated in pathological condition such as atherosclerosis and diabetes mellitus. It has been suggested to be involved in the pathogenesis of both macro- and microvascular complications. This study was designed to evaluate the effect of glycemic control on sRAGE and oxidative stress markers in type 2 diabetic patients.MethodsSeventy patients with type 2 diabetes and 20 healthy subjects were recruited into the study. Blood glutathione (GSH) and plasma total nitric oxide (NOx) levels were measured using commercially available colorimetric kits, blood superoxide dismutase (SOD) activity was measured by the method of Marklund and Marklund, and plasma C-peptide, oxidized LDL (ox-LDL), sRAGE, and VCAM-1 levels were measured using competitive ELISA kits.ResultsPlasma sRAGE levels were significantly lower (p < 0.05) while VCAM-1 levels were significantly higher (p < 0.05) in poorly controlled diabetic patients compared with healthy control. Blood GSH levels were significantly lower in diabetic patients compared with healthy control (p < 0.05). Plasma C-peptide, NOx, ox-LDL levels, and SOD activity were not significantly different in diabetic patients compared with healthy control. Plasma levels of sRAGE were negatively associated with circulating VCAM-1 levels in diabetic patients.ConclusionPoor glycemic control decreases plasma sRAGE and increases VCAM-1 levels while good glycemic control improves these abnormalities which provides benefit to diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Effect of glycemic control on soluble RAGE and oxidative stress in type 2 diabetic patients

et al. 2013

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“…Diabetes, by itself, increases the production of tissue damaging reactive oxygen species (ROS) [1] by glucose autoxidation and/or non-enzymatic protein glycosylation. [2] There are many clinical and experimental evidences indicating the involvement of oxidative stress in the pathogenesis of diabetes mellitus and more importantly in complications such as diabetic neuropathy, retinopathy and nephropathy.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic potential of Zanthoxylum armatum bark extract on streptozotocin-induced diabetic rats

Karki¹,

Upadhayay²,

Pal³

et al. 2014

Int J Green Pharm

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Objective: Hydromethanolic extract of the bark of Zanthoxylum armatum (HMZA) was evaluated for its antidiabetic and antioxidant activity in streptozotocin-induced diabetic rats. Materials and Methods: HMZA was evaluated in normal and diabetic rats. Diabetes was induced by streptozotocin (60 mg/kg i.p.). Normal and diabetic rats were divided into different groups and orally administered with HMZA (200 and 400 mg/kg) and glibenclamide (5 mg/kg) for 21 days. Blood samples were collected from overnight-fasted rats on at 7, 14 and 21 days of treatment and analysed for blood glucose level and lipid profile. On day 21, rats were sacrificed and liver and kidney tissues were excised to measure their antioxidant status. Results: Oral administration of HMZA for 21 days (200 and 400 mg/kg) resulted in significant reduction in blood glucose, total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein and significant increase in high density lipoprotein and body weight of streptozotocin diabetic rats. In addition to that, significant decrease in lipid peroxidation and increase in catalase, superoxide dismutase and reduced glutathione were observed in streptozotocin diabetic rats. Conclusion: From the present study, it is evident that, the bark of Z. armatum possesses significant antidiabetic and antioxidant effect on diabetic rats and suggests that the plant may have therapeutic value in diabetes and related complications.

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“…Oxidative stress has been suggested as a contributory factor in the pathogenesis of diabetes (Murugan and Pari, 2006). Diabetes, by itself, increases the production of tissue damaging reactive oxygen species (ROS) (Signorini et al, 2002) by glucose autoxidation and/or nonenzymatic protein glycosylation (Giuliano et al, 1996). Therefore, oxidative stress in diabetes is referred as a case of double jeopardy for any ␤-cells that survive the disease (Robertson and Harmon, 2006).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antidiabetic, antioxidant and vasoprotective effects of Posidonia oceanica extract

Gökçe

Haznedaroğlu

2008

Journal of Ethnopharmacology

105

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Antioxidant effects of gliclazide, glibenclamide, and metformin in patients with type 2 diabetes mellitus

Cited by 34 publications

References 31 publications

Effect of glycemic control on soluble RAGE and oxidative stress in type 2 diabetic patients

Effect of glycemic control on soluble RAGE and oxidative stress in type 2 diabetic patients

Antidiabetic potential of Zanthoxylum armatum bark extract on streptozotocin-induced diabetic rats

Evaluation of antidiabetic, antioxidant and vasoprotective effects of Posidonia oceanica extract

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