Antioxidant hydrocolloids from herb Graptopetalum paraguayense leaves show anti-colon cancer cells and anti-neuroinflammatory potentials

Ai, Lianzhong; Chung, Yun‐Chin; Jeng, Kee-Ching; Lai, Phoency F.-H.; Yeh, Shu-Chen; Lee, Kuan Ching; Lin, Syuan-Yu; Xia, Yongjun; Wang, Guangqiang; Cui, Steve W.

doi:10.1016/j.foodhyd.2017.06.027

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…The mixture was shaken gently and absorbance was read at 517 nm every 5 min, a total of 30 min. The ABTS + free-radical scavenging activity assay was performed as described by Ai 9 with slight modification. 7 mM ABTS + and 2.45 mM K 2 S 2 O 8 were dissolved in 10 mM sodium phosphate buffer and then placed at dark room for 16 h to obtain ABTS + stock solution.…”

Section: Methodsmentioning

confidence: 99%

“…The process of oxidative degradation, particularly that induced by reactive oxygen species (ROS), may lead to oxidative stress, which is an imbalance between antioxidant systems and the production of oxidants 7 . Oxidative stress is associated with many diseases, such as aging and cancer 8 , 9 . Antioxidants play a significant role in reducing aging effects, and thus the antioxidant property in designing whitening agent is highly considered.…”

Section: Introductionmentioning

confidence: 99%

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Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents

Chen

Zhang

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

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The novel kojic acid derivatives KAD1 and KAD2 have been demonstrated that they exhibited potent antimelanogenesis activity in our previous report. In this study, we further study the inhibitory mechanism on mushroom tyrosinase. The inhibitory types of both KADs on diphenolase were classified as mixed type based on the results of the kinetic model. The interaction between KADs and tyrosinase was illustrated by fluorescence quenching, molecular docking and copper chelate activity. The KADs were also evaluated with respect to their antioxidant activities by DPPH and ABTS þ assays. The results showed that KADs have more potent antioxidant activities than kojic acid. Our study could provide new ideas for the development of new anti-tyrosinase and antioxidant agents.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents

Chen

Zhang

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

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show abstract

“…According to the analysis conditions in our previous report [21], a high-resolution differential RI detector (Viscotek Co., Texas, USA) and guarded TSK GMPW XL column were employed. Elution was done with 50 mM NaNO 3 aqueous solution (containing 0.02 % (w/w) NaN 3 ) at a flow rate of 0.5 mL/min at 35 °C .…”

Section: Molecular Distribution Analysismentioning

confidence: 99%

Optimizing Extraction Process and Characterization of Antioxidant Ingredients from Chlorella Sorokiniana

Lai¹,

Sun²

2017

MOJFPT

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“…According to the analysis conditions in our previous report, 21 a high-resolution differential RI detector (Viscotek Co., Texas, USA) and guarded TSK GMPW XL column were employed. Elution was done with 50mM NaNO 3 aqueous solution (containing 0.02% (w/w) NaN 3 ) at a flow rate of 0.5mL/min at 35°C .…”

Section: Molecular Distribution Analysismentioning

confidence: 99%

Optimizing Extraction Process and Characterization of Antioxidant Ingredients from Chlorella Sorokiniana

Lai¹

2017

MOJFPT

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This study was to investigate optimized extraction conditions for Chlorella sorokiniana (C. sorokiniana) water extracts with antioxidant functionality and potential key compounds involved. A 2-factor, 5-level response surface methodology was employed using extraction temperature (40-100°C) and time (0.5-6h) as factors. It is indicated that, among the C. sorokiniana extracts examined, the maximal value in yield was 18.0% (w/w) on biomass basis; in 75% ethanol solubility of water extract (WS-E75S%, the potentially major antioxidant fraction), 38.0% (w/w) on extract basis; in total phenolic content (TPC), 3.17 GAEmg/g on extract basis. The highest antioxidant activities were shown by a 50% DPPH scavenging concentration (SC50)=7.36mg/ mL, 50% Fe2+ chelating concentration (CC50,)=10.4mg/mL, and reducing power increment per unit concentration=0.044mL/mg. By statistical analysis with RSREG program, the obtained polynomials for yield, WS-E75S%, SC50 and CC50 as a function of temperature and time could explain 78.9-82.2% of data variations. An optimal extraction condition was concluded at 100°C for 1h, to give high values in all yield, WS-E75S%, and antioxidant activities (i.e. low SC50 and CC50 values). In WS-E75S, the major compositions were likely nucleic acids and their analogues with ethylene structure, accompanying with detectable amounts of possibly polyunsaturated fatty acids, fatty alcohols, or phytols with acyl dienes, buta-1, 3-diene or ethylene structure. Besides these Phytochemicals, the water extract contained carbohydrates of mainly glucose and ribose (52.4 and 25.9mol%, respectively), followed by galactose and rhamnose, and two molecular fractions. Conclusively, Chlorella water extract at optimally 100 °C for 1h could yield~18% (w/w), contain WS-E75S~37% (w/w) and have statistically predicted SC50 ~3.0mg/mL and CC50 ~11mg/mL.

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Antioxidant hydrocolloids from herb Graptopetalum paraguayense leaves show anti-colon cancer cells and anti-neuroinflammatory potentials

Cited by 9 publications

References 36 publications

Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents

Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents

Optimizing Extraction Process and Characterization of Antioxidant Ingredients from Chlorella Sorokiniana

Optimizing Extraction Process and Characterization of Antioxidant Ingredients from Chlorella Sorokiniana

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