Antioxidant potential of methanolic extract of<i>Dolichos biflorus</i>Linn in high fat diet fed rabbits

Muthu, A. Kottai; Sethupathy, S; Manavalan, R.; Karar, P K

doi:10.4103/0253-7613.24620

Cited by 25 publications

(20 citation statements)

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“…The seeds are used in traditional formulations for the treatment of kidney stones, leucorrhoea, urinary disorders, and menstrual troubles (Ghani, 2003). The seeds of D. biflorus have also been reported to show hepatoprotective (Laskar et al, 1998), antitumour (Nanta & Kale, 2011), and hypolipidemic activity (Muthu et al, 2005). They are also known to be involved in lowering the level of blood sugar and total cholesterol (Pant et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Antinephrolithiatic and antioxidative efficacy ofDolichos biflorusseeds in a lithiasic rat model

Saha

Verma

2014

Pharmaceutical Biology

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Context: Dolichos biflorus sensu auct non L. (Fabaceae) is widely used for the treatment of kidney stones, leucorrhoea, urinary disorders, and menstrual troubles, and is known for its antioxidant activity. Objectives: To evaluate the preventive effect of hydro-alcoholic extract of Dolichos biflorus seeds (DBE) in ethylene glycol induced nephrolithiasis. Materials and methods: In vitro antioxidative capacity of DBE was estimated in terms of reducing power, superoxide radical, 2,2-diphenyl-1-picrylhydrazyl radical, and nitric oxide scavenging activity. A validated HPLC method was used for standardization using quercetin as a marker. Adult female Wistar rats were administered with DBE (150 and 300 mg/kg body weight/day) along with ethylene glycol (0.75%, v/v) for 28 d. The various biochemical parameters were measured in urine, serum, and kidney followed by histochemistry. Results: Ethylene glycol caused a significant increase in calcium, oxalate, phosphate, and total protein in urine as well as in kidney whereas decrease in calcium, sodium, and magnesium in serum was observed (p50.001). Ethylene glycol also caused a significant increase in lipid peroxidation and concurrent decrease in activities of antioxidant enzymes in kidney (p50.001). However, the seed extract of D. biflorus caused significant restoration of all these parameters (p50.001). Histopathological and histochemical studies also showed the reduced calcifications in kidney of seed extract treated rats. Discussion and conclusion: These results indicated that seeds of D. biflorus have significant prophylactic effect in preventing the nephrolithiasis, which might be due to the antioxidant activity of the active compounds of the plant.

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Section: Introductionmentioning

confidence: 99%

Antinephrolithiatic and antioxidative efficacy ofDolichos biflorusseeds in a lithiasic rat model

Saha

Verma

2014

Pharmaceutical Biology

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“…[28] Administration of D. biflorus extract to rabbits with high-fat diet induced oxidative stress showed improvement in antioxidant enzymes such as superoxide dismutase, catalase and increased glutathione concentration. [29] Chaitanya et al (2010) reported the antiurolithiatic activity of M. uniflorum seed extract on ethylene glycol induced urolithiasis in albino rats. [30] M. uniflorum seed showed significant hepatoprotective properties in D-galctosamine and paracetamol induced hepatotoxicity on rats.…”

Section: Discussionmentioning

confidence: 99%

Pharmacognostic and Physico-chemical standardization of Macrotyloma uniflorum (Lam.) verdc. edible seed

Bigoniya¹,

Sourabh²,

Shukla³

et al. 2014

Phcog Commn.

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“…Post-treatment with EEGS extract showed considerable reduction in phospholipid levels as compared to hypercholesterolemic rabbits. This may be attributed to the improved activity of phospholipases [25].…”

Section: Discussionmentioning

confidence: 99%

Anti-Atherosclerotic Activity of Elaeocarpus Ganitrus Roxb. In Cholesterol-Fed Rabbits

Jain

Joshi

2017

Asian J Pharm Clin Res

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Objectives: Atherosclerosis was experimentally induced in New Zealand white male rabbits by cholesterol feeding for 120 days for investigating effects of 70% ethanolic Elaeocarpus ganitrus seed extract (EEGS) against atherosclerosis.Methods: Anti-atherosclerotic activity of E. ganitrus extract was evaluated at a dose level of 250 and 500 mg/kg of body weight (p.o). On 121 st day, the animals were sacrificed to collect the aorta for determining tissue lipid profile, antioxidant parameters, and histopathological changes. One-way ANOVA followed by Tukey's multiple comparison test was used for the statistical analysis.Results: Aorta of cholesterol-fed rabbits for 120 days showed marked elevation in total cholesterol, triglycerides, and phospholipids. EEGS extract treatment significantly (p≤0.01, ≤0.001) corrected disturbed lipid profile in cholesterol-fed rabbits in a dose-dependent manner during the 60 days of the treatment period. A significant reduction in lipid peroxidation and a considerable raise in glutathione, catalase, and superoxide dismutase levels (p≤0.01, ≤0.001) were accompanied by post-treatment with EEGS extract to cholesterol-fed rabbits. The histopathological modifications such as accumulation of foam cells, atheromatous plaque formation, and lumen size reduction supported the successful induction of atherosclerosis in rabbits. The treated rabbits showed significant protective effect by lowering the deposition of cholesterol and increasing the lumen size compared to cholesterol-fed group.Conclusions: Phytoconstituents such as alkaloids, tannins, flavonoids, steroids, triterpenoids, and carbohydrates in the ethanolic extract may be attributed to effective anti-atherosclerotic and antioxidant activity of plant extract. Our study exhibited that EEGS extract could be a potent herbal therapeutic agent for the treatment of atherosclerosis and hypercholesterolemia-related diseases.

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Antioxidant potential of methanolic extract ofDolichos biflorusLinn in high fat diet fed rabbits

Cited by 25 publications

References 0 publications

Antinephrolithiatic and antioxidative efficacy ofDolichos biflorusseeds in a lithiasic rat model

Antinephrolithiatic and antioxidative efficacy ofDolichos biflorusseeds in a lithiasic rat model

Pharmacognostic and Physico-chemical standardization of Macrotyloma uniflorum (Lam.) verdc. edible seed

Anti-Atherosclerotic Activity of Elaeocarpus Ganitrus Roxb. In Cholesterol-Fed Rabbits

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