Antioxidant Properties of Microalgae Protein Hydrolysates Prepared by Neutral Protease Digestion

Hu, Xiao; Yang, Xian; Li, Lai Hao; Wu, Yan; Lin, Weigan; Huang, Hui; Yang, Shao Ling

doi:10.4028/www.scientific.net/amm.707.149

Cited by 6 publications

(7 citation statements)

References 8 publications

(9 reference statements)

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“…Bioactive peptides obtained after protein hydrolysis can have various beneficial effects. Hu et al [ 112 ] found that enzymatic hydrolysates of microalgae exhibit antioxidant properties. Chen et al [ 113 ] evaluated the hepatoprotective effect of the antioxidant peptide obtained by enzymatic hydrolysis from the microalgae Isochrysis Zhanjiangensis on alcohol damage to HepG2 cells.…”

Section: The Biological Activity Of Various Substances From Microamentioning

confidence: 99%

Microalgae: A Promising Source of Valuable Bioproducts

et al. 2020

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Microalgae are a group of autotrophic microorganisms that live in marine, freshwater and soil ecosystems and produce organic substances in the process of photosynthesis. Due to their high metabolic flexibility, adaptation to various cultivation conditions as well as the possibility of rapid growth, the number of studies on their use as a source of biologically valuable products is growing rapidly. Currently, integrated technologies for the cultivation of microalgae aiming to isolate various biologically active substances from biomass to increase the profitability of algae production are being sought. To implement this kind of development, the high productivity of industrial cultivation systems must be accompanied by the ability to control the biosynthesis of biologically valuable compounds in conditions of intensive culture growth. The review considers the main factors (temperature, pH, component composition, etc.) that affect the biomass growth process and the biologically active substance synthesis in microalgae. The advantages and disadvantages of existing cultivation methods are outlined. An analysis of various methods for the isolation and overproduction of the main biologically active substances of microalgae (proteins, lipids, polysaccharides, pigments and vitamins) is presented and new technologies and approaches aimed at using microalgae as promising ingredients in value-added products are considered.

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Section: The Biological Activity Of Various Substances From Microamentioning

confidence: 99%

Microalgae: A Promising Source of Valuable Bioproducts

et al. 2020

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“…Peptides from protein hydrolysis have been studied due to their bioactivities. Some peptides have potential benefits such as antioxidative (Hu et al 2015), binding or inhibiting specific receptors (Kalpa W. Samarakoon et al 2014), growth factors, hormones, immunomodulators (de Jesus Raposo et al 2013, antihypertensive, anticoagulant and antiproliferative (Kalpa Samarakoon and Jeon 2012).…”

Section: Proteins and Peptidesmentioning

confidence: 99%

Downstream Green Processes for Recovery of Bioactives from Algae

Bueno

Gallego

Mendiola

et al. 2019

Grand Challenges in Algae Biotechnology

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Nowadays, macro and microalgae are being increasingly used as promising raw materials for the food, cosmetic and pharmaceutical industries thanks to their biodiversity and its variety on valuable bioactive compounds such as carbohydrates, polyunsaturated lipids, proteins and pigments, among others. Furthermore, more efficient and environmentally friendly processes for bioactives' recovery are requested not only by the industry but also by the society. This book chapter presents an overview on the use of downstream green processes, mainly based on compressed fluids extraction techniques, in order to recover bioactives from algae that can be lately used in several potential applications for the food, pharmaceutical and cosmetic industries, which is the pillar of algae-based biorefinery.

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“…Protein hydrolysates from macro-and microalgae have been reported by various authors as possible therapeutic agents due to their antimicrobial and antiviral 3 , 4 , anticancer 5 , antioxidant 6 – 9 , and immunoregulatory functions 10 . Additionally, a close relationship has been observed between the antioxidant capacity of the protein hydrolysates and their hydrophobic and/or aromatic amino acid content 11 – 14 .…”

Section: Introductionmentioning

confidence: 99%

Taurine, homotaurine, GABA and hydrophobic amino acids content influences “in vitro” antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae

Terriente-Palacios

Rubiño

Hortós

et al. 2022

Sci Rep

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Prevention and control of diseases and delaying the signs of ageing are nowadays one of the major goals of biomedicine. Sirtuins, a family of NAD+ dependent deacylase enzymes, could be pivotal targets of novel preventive and therapeutic strategies to achieve such aims. SIRT1 activating and inhibiting compounds, such as polyphenols and bioactive peptides, have been proposed to be involved in the development of many human diseases. The objective of this work was to assess and compare the antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates (EPHs) from a wide number of algae species (24 commercial samples and 12 samples harvested off the Atlantic coast of northern Spain). High antioxidant activities were observed in EPHs from red and green seaweed species. Moreover, 19 samples exhibited SIRT1 activation, while EPHs from the 16 samples were SIRT1 inhibitors. Pearson's correlation test and Principal Component Analysis revealed significant correlations between (1) total peptide and hydrophobic amino acid content in EPHs and their antioxidant activities, and (2) concentrations of taurine, homotaurine, and amino acid gamma aminobutyric acid in EPHs and their SIRT1 modulation activity.

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Antioxidant Properties of Microalgae Protein Hydrolysates Prepared by Neutral Protease Digestion

Cited by 6 publications

References 8 publications

Microalgae: A Promising Source of Valuable Bioproducts

Microalgae: A Promising Source of Valuable Bioproducts

Downstream Green Processes for Recovery of Bioactives from Algae

Taurine, homotaurine, GABA and hydrophobic amino acids content influences “in vitro” antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae

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