Antioxidant Property of Aerial Parts and Root of<i>Phyllanthus fraternus</i>Webster, an Important Medicinal Plant

Upadhyay, Richa; Chaurasia, Jitendra Kumar; Tiwari, Kavindra Nath; Singh, Kulvir

doi:10.1155/2014/692392

Cited by 44 publications

(27 citation statements)

References 26 publications

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“…Antioxidant activity DPPH assay is quick, simple, and practical strategy to quantify an antioxidant effect, which includes the utilization of the free radical [30], DPPH. DPPH is usually used to test the capacity of mixes to go about as free extreme foragers or hydrogen contributors and it depends on the capacity of DPPH to decolorize within the sight of antioxidant [31,32].…”

Section: Resultsmentioning

confidence: 99%

In Vitro Antioxidant and Anti-Inflammatory Activity of the Flower Extracts of Opuntia Stricta

Prabhakaran

Rajeshkanna

Mm³

2019

Asian J Pharm Clin Res

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Objective: The objective of this study was to evaluate the antioxidant and anti-inflammatory activities of the solid powder obtained from the ethyl acetate fraction from the flower Opuntia stricta. Methods: The flower extract was evaluated for antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay and reducing power assay was carried out by ferric-reducing capacity (FRC) assay method. The in vitro anti-inflammatory activity was evaluated using human peripheral blood mononuclear cells (PBMCs) stimulated by lipopolysaccharide (LPS) to evaluate nitric oxide (NO) production method. Results: The solid powder obtained from the ethyl acetate fraction from the flower O. stricta showed a good antioxidant activity in scavenging DPPH radical and FRC assay with compared standard sample. This solid powder also showed good anti-inflammatory activity in cell viability (LPS-induced PBMCs) assay and NO assay. Conclusion: These results suggest that the solid powder obtained from the ethyl acetate fraction from the flower O. stricta has significant antioxidant and anti-inflammatory activities.

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Section: Resultsmentioning

confidence: 99%

In Vitro Antioxidant and Anti-Inflammatory Activity of the Flower Extracts of Opuntia Stricta

Prabhakaran

Rajeshkanna

Mm³

2019

Asian J Pharm Clin Res

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“…As an alternative, external source of antioxidants can delay or inhibit the oxidative damage. 20,21 Various authors have demonstrated that some medicinal plants contain high concentrations of free radical scavenging molecules. Among these molecules, phenolic compounds such as flavonoids and tannins, present potential antioxidant activity and act directly on ROS and RNS by neutralizing them or inhibiting their production.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-inflammatory Activities of Bauhinia ungulata L. (Fabaceae) on LPS-Stimulated RAW 264.7 Cells

Rodrigues¹,

Yaochite²,

Braga³

et al. 2019

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The genus Bauhinia (family Fabaceae) is widely distributed worldwide and is frequently used in folk medicine-related practices. For instance, leaves, stems and roots are employed for the treatment of diabetes mellitus, inflammatory processes, infections and pain. 1 In vitro and in vivo studies have suggested that the therapeutic properties of the plant are mostly due to the presence of flavonoids. 2 Bauhinia ungulata L, a Brazilian native species, is popularly known as "pata-de-vaca", 3 and can be found in various regions of the country. The popular use of this plant in Brazil originates mainly from its hypoglycemic properties. 4 Phytochemical analysis of leaves of B. ungulata L. revealed the presence of quercetin, quercetin arabinofuranoside, quercitrin and the alkaloids, harmane Antioxidant and Anti-inflammatory Activities of Bauhinia ungulata L. (Fabaceae) on LPS-Stimulated RAW 264.7 Cells ABSTRACT Objective: The present study aimed to investigate the antioxidant, immunomodulatory and antimicrobial activities of Bauhinia ungulata L. Method: A flavonoid-rich fraction was obtained from the Bauhinia ungulata L stem, called the ethyl acetate fraction of Bauhinia ungulata (FABU). The total antioxidant capacity of the FABU was determined through the phosphomolibdenium reduction method. For the evaluation of its antioxidant activity on a cell culture model, LPS-stimulated RAW 264.7 cells were treated with different concentrations of FABU and the reactive oxygen species (ROS), nitric oxide (NO), hydrogen peroxide (H 2 O 2) and thiobarbituric acid reactive substances (TBARS) production levels were measured. For the analysis of its immunomodulatory capacity, TNF-α, TGF-β and IL-10 levels were determined in the culture supernatant. In order to determinate the antimicrobial activity of FABU, antifungal and antibacterial susceptibility testing was performed against Candida albicans, methicillinsensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa strains. Result: The FABU demonstrated neither significant antimicrobial activity nor immunodulatory capacity; on the other hand, its potential antioxidant activity was demonstrated by the phosphomolibdenium reduction assay. Also, FABU treatment inhibited the ROS, NO, H 2 O 2 and TBARS levels in the supernatant of LPS-stimulated cells. Conclusion: A significant reduction in the amount of reactive oxygen and nitrogen species (RONS) was observed, in addition to lipid peroxidation inhibition. Our data suggest that the FABU is a natural antioxidant complex that may interfere in the cascade of cell damage caused by free radicals and a promising potential drug in chronic disease models in which immunopathogenicity involves high levels of RONS.

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“…Butanol (5 ml) was added to each tube after cooling and centrifuged at 3000 rpm for 10 min. The absorbance of the organic upper layer was measured at 532 nm 15 .…”

Section: Interaction With Stable Free Radical Dpphmentioning

confidence: 99%

Untitled

2019

IJPSR

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1,3-Indanedione derivatives, which are of wide interest because of their diverse biological and chemical applications. A series of novel 1,3-Indanedione derivatives are synthesized via KNOEVENAGEL condensing reaction mechanism by condensing 1,3-Indanedione with the 1-(4-aminophenyl) ethanone to form a styrylated indanedione leading to the formation of different Schiff base (imine) preparation by using different aldehydes with the appropriate solvent mix at a suitable temperature. All the synthetic derivatives were fully characterized by spectral analysis data (FT-IR, NMR, and Mass). The newly synthesized compounds are evaluated for their antimicrobial activity (by using Cup-Plate method against selected bacterial strains amongst S. aureus, E. coli among total compounds, compounds 7 was found to have higher activity against selected strains and the results were found to be as moderate activity, for anti-fungal activity-compounds 2,8 are more potent, compounds are evaluated for their antioxidant NO scavenging (compound 7 is having more activity), for DPPH scavenging (compound 8 is having more activity), and inhibition of lipid peroxidation (compounds 3 and 9 are having more activity), for anti-oxidative activity moderate results are demonstrated. The potential importance of the pharmacophore, styryl, imine notices a role in the development of new potential anti-bacterial, anti-fungal, and anti-oxidative agents.

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Antioxidant Property of Aerial Parts and Root ofPhyllanthus fraternusWebster, an Important Medicinal Plant

Cited by 44 publications

References 26 publications

In Vitro Antioxidant and Anti-Inflammatory Activity of the Flower Extracts of Opuntia Stricta

In Vitro Antioxidant and Anti-Inflammatory Activity of the Flower Extracts of Opuntia Stricta

Antioxidant and Anti-inflammatory Activities of Bauhinia ungulata L. (Fabaceae) on LPS-Stimulated RAW 264.7 Cells

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