Antioxidant Therapy and its Effectiveness in Oxidative Stress‐Mediated Disorders

Iannitti, Tommaso; Palmieri, Beniamino

doi:10.1002/9781118148143.ch15

Cited by 6 publications

(8 citation statements)

References 187 publications

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“…Furthermore, Nacetylglucosamine inhibited UVB-induced collagenolytic MMP production through different pathways in immortalized human skin fibroblasts [50]. Exogenous antioxidants have been extensively used to target pathology-related oxidative stress in different body systems, as previously reviewed [51,52]. Specifically, topical pycnogenol and oral coenzyme Q10 have shown promising results in the treatment of photoaging-induced oxidative damage at the level of the skin as reviewed by Berson [53].…”

Section: Methodsmentioning

confidence: 99%

A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins

Cerbo

Laurino

Palmieri

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

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We found significantly increased serum levels of neutrophil elastase 2, elastin and carbonylated proteins and decreased levels of hyaluronic acid and fibronectin in patients affected by facial photoaging, if compared with healthy controls. These findings coupled with a significant decrease in skin hydration, tonicity and elasticity and increased skin pH and sebum. Treatment with the dietary supplement VISCODERM Pearls significantly improved VAS photoaging score and skin hydration, sebum and tonicity 2 weeks after the end of a 4-week treatment period in patients affected by moderate to severe facial photoaging. These findings coupled with a significant increase in serum fibronectin and hyaluronic acid and a decrease in serum carbonylated proteins and neutrophil elastase 2 in the active treatment group, if compared with placebo. Our findings suggest that VISCODERM Pearls is effective for treatment of facial photoaging but further studies in larger cohorts of patients are required.

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Section: Methodsmentioning

confidence: 99%

A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins

Cerbo

Laurino

Palmieri

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

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“…Free radicals, including reactive oxygen species (ROS), are generated as a normal by-product of respiration, and at low concentrations, they act as signalling molecules and are essential for normal cell and tissue homeostasis [1,2]. Under normal physiological conditions, a delicate balance between the rate of ROS generation and the activity of antioxidant systems is maintained [3,4]. Under pathological conditions, this balance is often disrupted, which can lead to changes in biological function [3,5].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Label-Free Confocal Raman Microspectroscopy for Monitoring Oxidative Stress In Vitro in Live Human Cancer Cells

2022

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Understanding the impact of free radicals and antioxidants in cell biology is vital; however, noninvasive nonperturbative imaging of oxidative stress remains a challenge. Here, we evaluated the ability of label-free Raman spectroscopy to monitor redox biochemical changes in antioxidant (N-acetyl-l-cysteine, NAC) and pro-oxidant (tert-butyl hydroperoxide, TBHP) environments. Cellular changes were compared to fluorescence microscopy using CellROX Orange as a marker of oxidative stress. We also investigated the influence of cell media with and without serum. Incubation of cells with NAC increased the Raman signal at 498 cm−1 from S-S disulphide stretching mode, one of the most important redox-related sensors. Exposure of cells to TBHP resulted in decreased Raman spectral signals from DNA/proteins and lipids (at 784, 1094, 1003, 1606, 1658 and 718, 1264, 1301, 1440, 1746 cm−1). Using partial least squares–discriminant analysis, we showed that Raman spectroscopy can achieve sensitivity up to 96.7%, 94.8% and 91.6% for control, NAC and TBHP conditions, respectively, with specificity of up to 93.5, 90.1% and 87.9%. Our results indicate that Raman spectroscopy can directly measure the effect of NAC antioxidants and accurately characterize the intracellular conditions associated with TBHP-induced oxidative stress, including lipid peroxidation and DNA damage.

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“…e reason of oxidative stress in menopause might be diminished levels of estrogen, which is a natural antioxidant by itself, and causes changes in lipid profile and in turn enhanced lipid peroxidation [8]. Studies have indicated that oxidative stress plays a significant role in the pathogenesis of diseases associated with menopause including coronary artery disease, neurological disease, and vasomotor disorders [3,9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women

Zovari

Parsian

Bijani

et al. 2020

International Journal of Dentistry

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Objective. In menopause, reduction of estrogen hormone affects oxidative stress process in serum. Oxidative stress in saliva plays a significant role in the pathogenesis of oral diseases. The aim of this study was to investigate the total antioxidant capacity and lipid peroxidation in the serum and saliva of premenopausal and postmenopausal women. Methods. In this case control study, 50 postmenopausal women (case group) and 48 premenopausal women (control group) were selected. The unstimulated whole saliva and serum of the postmenopausal and premenopausal women were collected. The total antioxidant capacity (TAC) of the saliva and serum was measured by ferric reducing antioxidant power (FRAP). Also, malondialdehyde (MDA) was measured by thiobarbituric acid reactive substance (TBARS) method for serum and saliva. Then, the obtained data were analyzed by SPSS 17, whereby Mann–Whitney test and Spearman’s correlation test were used. P < 0.05 was considered statistically significant. Results. The postmenopausal group had significantly lower mean serum TAC and higher mean serum MDA than the control group ( P < 0 < 001 and P < 0.01 , respectively). The mean salivary TAC and MDA, however, did not differ significantly between the case and control group ( P = 0.64 and P = 0.08 , respectively). Conclusion. In postmenopausal women, with elevation of serum MDA and reduction of serum TAC, the extent of serum oxidative stress grows, but MDA and TAC levels of saliva do not change.

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Antioxidant Therapy and its Effectiveness in Oxidative Stress‐Mediated Disorders

Cited by 6 publications

References 187 publications

A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins

A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins

Evaluation of Label-Free Confocal Raman Microspectroscopy for Monitoring Oxidative Stress In Vitro in Live Human Cancer Cells

Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women

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