Antioxidants for preventing and reducing muscle soreness after exercise

Ranchordas, Mayur; Rogerson, David; Soltani, Hora; Costello, Joseph

doi:10.1002/14651858.cd009789.pub2

Cited by 36 publications

(36 citation statements)

References 142 publications

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“…On the other hand, Liu et al [117] showed that if male Sprague-Dawley rats were given a antioxidant supplement of lycopene (a relatively high dose (7.8 mg/kg/d) and a relatively low dose (2.6 mg/kg/d) for 30 days), there was no significant difference between the use of different antioxidant doses in the enhancement of glutathione antioxidant enzymes. Additionally, in a recent meta-analysis of 50 studies, it was clearly stated that exercise-induced muscle pain did not decrease even with high-dose antioxidant supplements [118] (Table 3).…”

Section: The Effect Of Different Doses Of Antioxidant Supplements On Osmentioning

confidence: 99%

A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation

Taherkhani

Castell

2020

Antioxidants

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Excessive release of inflammatory cytokines and oxidative stress (OS) are triggering factors in the onset of chronic diseases. One of the factors that can ensure health in humans is regular physical activity. This type of activity can enhance immune function and dramatically prevent the spread of the cytokine response and OS. However, if physical activity is done intensely at irregular intervals, it is not only unhealthy but can also lead to muscle damage, OS, and inflammation. In this review, the response of cytokines and OS to exercise is described. In addition, it is focused predominantly on the role of reactive oxygen and nitrogen species (RONS) generated from muscle metabolism and damage during exercise and on the modulatory effects of antioxidant supplements. Furthermore, the influence of factors such as age, sex, and type of exercise protocol (volume, duration, and intensity of training) is analyzed. The effect of antioxidant supplements on improving OS and inflammatory cytokines is somewhat ambiguous. More research is needed to understand this issue, considering in greater detail factors such as level of training, health status, age, sex, disease, and type of exercise protocol.

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Section: The Effect Of Different Doses Of Antioxidant Supplements On Osmentioning

confidence: 99%

A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation

Taherkhani

Castell

2020

Antioxidants

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“…One of them is the enzyme glutathione peroxidase (GPx). This enzyme uses glutathione to reduce peroxides, thereby protecting membranes and other cellular structures from the action of lipid peroxides and free radicals [51]. In addition, catalase (CAT) is one of the enzymes involved in the destruction of hydrogen peroxide generated during cell metabolism [52].…”

Section: Effect On Oxidative Markersmentioning

confidence: 99%

Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review

et al. 2020

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Physical activity, particularly high-intensity eccentric muscle contractions, produces exercise-induced muscle damage (EIMD). The breakdown of muscle fibers and the consequent inflammatory responses derived from EIMD affect exercise performance. Curcumin, a natural polyphenol extracted from turmeric, has been shown to have mainly antioxidant and also anti-inflammatory properties. This effect of curcumin could improve EIMD and exercise performance. The main objective of this systematic review was to critically evaluate the effectiveness of curcumin supplementation on EIMD and inflammatory and oxidative markers in a physically active population. A structured search was carried out following Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines in the databases SCOPUS, Web of Science (WOS), and Medline (PubMed) from inception to October 2019. The search included original articles with randomized controlled crossover or parallel design in which the intake of curcumin administered before and/or after exercise was compared with an identical placebo situation. No filters were applied to the type of physical exercise performed, the sex or the age of the participants. Of the 301 articles identified in the search, 11 met the established criteria and were included in this systematic review. The methodological quality of the studies was assessed using the McMaster Critical Review Form. The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-8; and may have a slight antioxidant effect. In summary, the administration of curcumin at a dose between 150–1500 mg/day before and during exercise, and up until 72 h’ post-exercise, improved performance by reducing EIMD and modulating the inflammation caused by physical activity. In addition, humans appear to be able to tolerate high doses of curcumin without significant side-effects.

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“…Seven studies reported no adverse effects of taking the antioxidant supplementation 42 45 46 51 53 65 66. The remaining 41 studies failed to report adverse effects 24…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, antioxidant supplements are available to buy from supermarkets and health food stores and some are marketed to enhance recovery. Despite the popularity of antioxidant supplements, the evidence supporting its use is mixed 21–24. Therefore, the objective of this systematic review was to determine whether antioxidant supplements and antioxidant-enriched foods could prevent or reduce DOMS after exercise.…”

Section: Introductionmentioning

confidence: 99%