Antioxidative and antidiabetic effects of Capparis spinosa fruit extract on high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats

Assadi, Shahabaddin; Shafiee, Sayed Mohammad; Erfani, Mehran; Akmali, Masoumeh

doi:10.1016/j.biopha.2021.111391

Cited by 25 publications

(21 citation statements)

References 31 publications

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“…The hydroethanolic fruit extract of Caper produced a significant reduction of fasting blood glucose levels in type-2 diabetic rats by 16% at a concentration of 200 mg/kg and by 20% at 400 mg/kg compared to streptozotocin (STZ). However, a significant effect on lipid profile was observed only at the concentration of 400 mg/kg, mitigating liver oxidative stress and increasing detoxification enzyme levels (Assadi et al, 2021). Similar results were found earlier by (Kazemian et al, 2015) using 70% ethanolic extract of the roots of Caper at the same doses (200 and 400 mg/kg).…”

Section: Antidiabetic Activitysupporting

confidence: 89%

“…The reflux extract showed the highest capacity to reduce DPPH with IC 50 of 36.6 mg/mL; the ultrasound-assisted extract showed the highest ABTS scavenging activity with 258.77 mg of ascorbic acid equivalent/g dry weight (DW), while the macerated extract showed the highest FRAP activity with EC 50 equal to 120.2 mg/mL (Yahia et al, 2020). Likewise, the acetone 80% extract of fresh buds showed significant DPPH scavenging activity with IC 50 = 5.90 μg/mL (El amri et al, 2019) as do the hydro-ethanolic extracts of different tissues towards DPPH radical with IC 50 values of 1.41 mg/ml, 1.56 mg/ml, and 2.49 mg/mL, for leaves, fruits, and buds extracts, respectively (Assadi et al, 2021). In the same line, Saleem et al (2021) compared the antioxidant activity of the methanol and dichloromethane (DCM) extracts of plant aerial parts and roots.…”

Section: Antioxidant Potencymentioning

confidence: 90%

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Caper (Capparis spinosa L.): An Updated Review on Its Phytochemistry, Nutritional Value, Traditional Uses, and Therapeutic Potential

Annaz

Sane²,

Bitchagno³

et al. 2022

Front. Pharmacol.

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Caper (Capparis spinosa L.) is a perennial shrub of the family Capparaceae, endemic to circum-Mediterranean countries. Caper carries a renowned nutritional value, especially in terms of vitamins and antioxidants related to the occurrence of flavonoids, alkaloids, and glucosinolates as main secondary metabolites. Caper extracts have also shown to display antibacterial, antifungal, analgesic, antitumor, hepatoprotective, antioxidant, anti-inflammatory, and neuroprotective effects which correlate the uses of the plant in folk medicine against both metabolic and infectious diseases. The present review aims to provide exhaustive phytochemistry and pharmacological properties survey on Caper constituents. Attention has also been given to the nutritional values and traditional uses of main organs to pinpoint research gaps for future investigations on the plant.

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Section: Antidiabetic Activitysupporting

confidence: 89%

Section: Antioxidant Potencymentioning

confidence: 90%

Caper (Capparis spinosa L.): An Updated Review on Its Phytochemistry, Nutritional Value, Traditional Uses, and Therapeutic Potential

Annaz

Sane²,

Bitchagno³

et al. 2022

Front. Pharmacol.

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“…Furthermore, in contrast to the result, HFD-fed rats were found to have decreased specific activities of hepatic antioxidant enzymes, including CAT, glutathione peroxidase (GPx), glutathione reductase (GR), and GST, and decreased GSH levels that were reversed into increased activities by Capparis spinosa fruit extract treatment in a dose-dependent manner [ 57 ]. Also, it was indicated that HFD induced accumulation of ROS and the downregulation of the enzyme-related gene expressions that control the neutralization of such oxidative stress [ 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Crocodile Oil (Crocodylus siamensis) on Liver Enzymes: Cytochrome P450 and Glutathione S-Transferase Activities in High-fat DietFed Rats

Santativongchai

Srisuksai

Parunyakul

et al. 2022

Veterinary Medicine International

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Crocodile oil is a highly effective treatment for ailments ranging from skin conditions to cancer. However, the effects of the oil on liver detoxification pathways are not well studied. This study aimed to investigate the effects of crocodile oil on the detoxification enzyme activities and the mRNA expressions of cytochrome P450 1A2 (CYP1A2), cytochrome P450 2E1 (CYP2E1), and glutathione S-transferase (GST) in rats. The rats were divided into four groups (n = 7/group): rats received a standard diet (C), a high-fat diet or HFD (H), and HFD with 1 ml (HCO1) and 3 ml (HCO3) of the oil per kg body weight. Interestingly, the oil yields from this study presented alpha-linolenic acid (0.96%) at similar levels compared with fish oil. The results revealed that HFD significantly increased the activity and relative gene expression of CYP1A2 in the H group ( P < 0.05 ), whereas 3% crocodile oil normalized the enzyme activities compared to the C group. This suggested inhibiting the HFD-induced expression of CYP1A2 mediated by the omega-3 fatty acids found in the oil. Also, crocodile oil supplementation did not reduce the activities of GST. However, the relative gene expression of GSTA1 was significantly decreased ( P < 0.05 ) in the HCO1 and HCO3 groups compared to the H group, which might be attributed to the lower lipid peroxidation that occurred in the liver tissues. Therefore, it could be suggested that using crocodile oil could help in liver detoxification through the CYP1A2 even when offered with a HFD.

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“…Hence, there is a need to find new alternatives, and scientists are now evaluating herbal and complementary medications that have interestingly shown an improvement in glucose homeostasis. Studies have reported that several herbal constituents such as flavonoids, phenolic compounds, terpenoids, alkaloids, glycosides, and coumarins exert a beneficial effect on carbohydrate regulation . The traditional system of herbal medicines has offered some promising alternate therapies for TII DM .…”

Section: Introductionmentioning

confidence: 99%

“…Studies have reported that several herbal constituents such as flavonoids, phenolic compounds, terpenoids, alkaloids, glycosides, and coumarins exert a beneficial effect on carbohydrate regulation. 14 The traditional system of herbal medicines has offered some promising alternate therapies for TII DM. 15 Extracts of medicinal plants offer a wide diversity of chemical constituents, which can lead to the discovery of novel antidiabetic agents.…”

Section: Introductionmentioning

confidence: 99%

Aqueous Ethanolic Extract of Adiantum incisum Forssk. Protects against Type 2 Diabetes Mellitus via Attenuation of α-Amylase and Oxidative Stress

et al. 2022

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This study was designed to investigate the antidiabetic effects of the aqueous ethanolic extract of Adiantum incisum Forssk. whole plant (AE-AI) in order to validate the folkloric claim. Methods: Streptozotocin (STZ) was used to induce type 2 diabetes mellitus (TII DM) in male Sprague−Dawley rats. STZ-induced diabetic rats were later treated orally with either AE-AI (125, 250, and 500 mg/kg) or glibenclamide for 35 days. Blood glucose levels were measured weekly and on day 35, animals were sacrificed, and blood samples and tissues were harvested for subsequent antioxidant and histopathological analyses. AE-AI was also analyzed in vitro for phytochemical, antioxidant, and α-amylase inhibitory assays. Results: The phytochemical screening of AE-AI confirmed the presence of essential bioactive compounds like cardiac glycosides, flavonoids, phenolic compounds, saponins, and fixed oils. AE-AI demonstrated abundant amounts of total phenolic and flavonoid contents and displayed prominent antioxidant activity as assessed via DPPH, phosphomolybdate, and nitric oxide scavenging assays. AE-AI treatment also showed α-amylase inhibitory activity comparable to acarbose. In addition, AE-AI treatment exhibited a wide margin of safety in rats and dosedependently reduced STZ-induced blood glucose levels. Moreover, AE-AI increased the levels of GSH, SOD, catalase, and reduced MDA, and therefore prevented pathological effects of STZ on the kidney, liver, and pancreas. The blood glucose regulatory effect and antioxidant activity of AE-AI also aided in normalizing TII DM-mediated dyslipidemias. GC-MS analysis also demonstrated several potential antidiabetic phytoconstituents in AE-AI. Conclusion: These findings reveal that AE-AI possesses certain pharmacologically active compounds that can effectively treat STZ-induced TII DM owing to its antioxidant and α-amylase inhibitory potentials.

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Antioxidative and antidiabetic effects of Capparis spinosa fruit extract on high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats

Cited by 25 publications

References 31 publications

Caper (Capparis spinosa L.): An Updated Review on Its Phytochemistry, Nutritional Value, Traditional Uses, and Therapeutic Potential

Caper (Capparis spinosa L.): An Updated Review on Its Phytochemistry, Nutritional Value, Traditional Uses, and Therapeutic Potential

Effects of Crocodile Oil (Crocodylus siamensis) on Liver Enzymes: Cytochrome P450 and Glutathione S-Transferase Activities in High-fat DietFed Rats

Aqueous Ethanolic Extract of Adiantum incisum Forssk. Protects against Type 2 Diabetes Mellitus via Attenuation of α-Amylase and Oxidative Stress

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