Antioxidative and digestion enzyme inhibitory activity of Ganoderma lucidum depends on the extraction solvent

Joo, Ok Soo; Hwang, Chung Eun; Hong, Su Young; Sin, Eui Cheol; Nam, Sang Hae; Cho, Kye Man

doi:10.11002/kjfp.2018.25.1.124

Cited by 9 publications

(3 citation statements)

References 24 publications

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“…Chen et al [ 39 ] investigated the amylase and glucosidase inhibitory effects of five Ganoderma species and their triterpenoids, and G. lucidum triterpenes demonstrated the strongest inhibitory effect with the lowest IC 50 values. Similar results of isolated compounds from the members of Ganoderma were also reported by several authors [ 40 , 41 , 42 ].…”

Section: Resultssupporting

confidence: 90%

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

et al. 2022

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Fungal mycelium cultures are an alternative to natural sources in order to obtain valuable research materials. They also enable constant control and adaptation of the process, thereby leading to increased biomass growth and accumulation of bioactive metabolites. The present study aims to assess the biosynthetic potential of mycelial cultures of six Ganoderma species: G. adspersum, G. applanatum, G. carnosum, G. lucidum, G. pfeifferi, and G. resinaceum. The presence of phenolic acids, amino acids, indole compounds, sterols, and kojic acid in biomass extracts was determined by HPLC. The antioxidant and cytotoxic activities of the extracts and their effects on the inhibition of selected enzymes (tyrosinase and acetylcholinesterase) were also evaluated. The total content of phenolic acids in the extracts ranged from 5.8 (G. carnosum) to 114.07 mg/100 g dry weight (d.w.) (G. pfeifferi). The total content of indole compounds in the extracts ranged from 3.03 (G. carnosum) to 11.56 mg/100 g d.w. (G. lucidum) and that of ergosterol ranged from 28.15 (G. applanatum) to 74.78 mg/100 g d.w. (G. adspersum). Kojic acid was found in the extracts of G. applanatum and G. lucidum. The tested extracts showed significant antioxidant activity. The results suggest that the analyzed mycelial cultures are promising candidates for the development of new dietary supplements or pharmaceutical preparations.

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Section: Resultssupporting

confidence: 90%

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

et al. 2022

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“…The fermentation broth of Reishi showed exceptional antidiabetic potential, considering that it inhibited the activity of α-amylase by as much as 78%. 51 Moreover, Reishi extract has also been shown to be very effective at inhibiting α-glucosidase in the study of Joo et al , 52 who reported an inhibition extent of 89.68%.…”

Section: Discussionmentioning

confidence: 99%

The chemical profiling and assessment of antioxidative, antidiabetic and antineurodegenerative potential of Kombucha fermented Camellia sinensis, Coffea arabica and Ganoderma lucidum extracts

et al. 2023

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“…GL was extracted according to a previous study [ 12 ]. Dried GL was produced by Imsil Lingzi mushroom farming association corporation (Jeonbuk, Korea).…”

Section: Methodsmentioning

confidence: 99%

Ganoderma lucidum Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver

Jung

Son

Hwang

et al. 2018

JCM

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Non-alcoholic steatosis is a common health problem worldwide due to altered food habits and life styles, and it is intimately linked with various metabolic disorders. In the present study, we investigated the molecular mechanism of Ganoderma lucidum (GL) against the development of non-alcoholic steatosis using in vivo and in vitro settings. C57BL/6 mice fed with normal diet (ND) or high fat diet (HFD) were administered GL extract or vehicle for 16 weeks. HFD feeding increased serum alanine aminotransferase level and hepatic lipid droplet, but these increases were significantly attenuated by GL. GL inhibited the increases in epididymal and perirenal adipose tissue weights and serum cholesterol and LDL levels in HFD-fed mice. Fasting blood glucose levels were elevated in HFD-fed mice compared to ND-fed mice, and glucose and insulin sensitivities were deteriorated. These changes were markedly improved by GL. GL restored the reduction of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) phosphorylation in the liver of HFD-fed mice, and increased AMPK and ACC phosphorylation in HepG2 and 3T3-L1 cells. GL induced GLUT4 protein expression in 3T3-L1 cells. Finally, GL attenuated lipid accumulation induced by free fatty acid in HepG2 cells. Taken together, our results indicate that GL has a potential to improve non-alcoholic steatosis and the associated complicated disorders via the induction of energy metabolizing enzymes.

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Antioxidative and digestion enzyme inhibitory activity of Ganoderma lucidum depends on the extraction solvent

Cited by 9 publications

References 24 publications

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

The chemical profiling and assessment of antioxidative, antidiabetic and antineurodegenerative potential of Kombucha fermented Camellia sinensis, Coffea arabica and Ganoderma lucidum extracts

Ganoderma lucidum Ameliorates Non-Alcoholic Steatosis by Upregulating Energy Metabolizing Enzymes in the Liver

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