Antioxidative phenolic compounds from the roots ofRhodiola sachalinensis A. Bor

Lee, Min Won; Lee, Yeon Ah; Park, Hyang Mi; Toh, Sang Hak; Jang, Hae‐Dong; Kim, Young Ho

doi:10.1007/bf02976571

Cited by 95 publications

(50 citation statements)

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“…Rhodiola rosea L. (Crassulaceae), an herbaceous plant, is used in Asian and Eastern European traditional medicines for its pressure-reducing [4], neurosystem-stimulating [5], fatigue-removing [6], hypobaropathy-preventing [7], antidepressive [7], anticancer [8], antiaging [9], cardiovascular-protective [10], and hepatoprotective effects [11]. Chemical investigations on this plant have revealed many chemical entities, including phenolic acids [12], phenolethanoids [13], phenylpropenoids [14], flavonoids [15], monoterpenes [4], and glycosides [16]. In a preliminary biological evaluation, crude extracts of R. rosea roots exhibited inhibitory activities toward MMP-2 and collagenase at a concentration of 100 µg/mL [17].…”

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confidence: 99%

“…Flash column separation of this layer over silica gel afforded three previously unreported chemical entities (1-3) along with twentyfour known compounds. The known compounds were identified to be methyl 4-hydroxybenzoate (4) [18], β-sitosterol (5) [19], (Z)-2-methyl-6-oxo-2-hepten-1-ol (6) [20], gallic acid (7) [21], 4-hydroxyphenyl-2-ethyl β-D-glucopyranoside (8) [22], tyrosol (9) [23], methyl gallate (10) [24], p-coumaric acid (11) [25], caffeic acid (12) [25], aspergillol B (13) [26], 2R,3R-dihydrokaempferol (14) [27], (E)-2-methyl-6-oxo-2-hepten-1-ol (15) [33], creoside III (25) [33], salidroside (26) [34], and icariside D2 (27) [35] based on spectroscopic data analysis and comparison to the literature. Compound 1, obtained as amorphous white powder, had a formula of C 41 H 32 O 24 , as determined using 13 (C-5), δ H 2.12 (H 3 -7)/δ C 211.4 (C-6) and 43.7 (C-5) and δ H 4.22 (H-1′)/δ C 75.6 (C-1) indicated that the aglycone of 2 was connected with the C-1′ of β-D-glucopyranoside via an ether linkage to form creoside I.…”

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Anti-MMP-2 Activity and Skin-Penetrating Capability of the Chemical Constituents from Rhodiola rosea

et al. 2016

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Introduction !Matrix metalloproteinases (MMPs) are a family of zinc-and calcium-dependent endopeptidases, which are grouped into the metzincin clan of metallopeptidases (MPs) together with other families such as ADAMs/adamalysins, astacins, fragilysins, and serralysins. MMPs are found throughout the animal and plant kingdoms, where their distribution is consistent with a Darwinian tree-based pathway [1]. Furthermore, polyplication has led to the presence of several paralogous MMP genes in the same organism: 24 in humans, 26 in sea urchins, 26 in zebrafish, 7 in sea squirts, and 2 in fruit flies. Overexpression of MMPs may cause various inflammatory, malignant, and degenerative symptoms [2]. Among the MMPs studied, gelatinase-A (MMP-2), gelatinase-B (MMP-9), and collagenase-1 (MMP-1) were reported to be responsible for the signal transduction of dermal photoaging [3], and inhibition of the activities of these two enzymes could potentially slow down skin aging. Thus, the search for bioactive compounds that can regulate the activities of MMP-1, -2, and -9 from natural resources is one of the key steps in delaying skin aging. [16]. In a preliminary biological evaluation, crude extracts of R. rosea roots exhibited inhibitory activities toward MMP-2 and collagenase at a concentration of 100 µg/mL [17]. An investigation of the active principles of this plant was thus undertaken by using a bioassayguided method. Of the tested water, n-butanol, and ethyl acetate layers, the ethyl acetate layer Abstract ! Based on the significant inhibitory activity toward matrix metalloproteinase-2 and collagenase noticed in preliminary studies, crude extracts of Rhodiola rosea were partitioned and chromatographed sequentially to afford three new compounds, 1,2,3,6-tetra-O-galloyl-4-O-p-hydroxybenzoyl-β-D-glucopyranoside (1), (E)-creoside I (2), and (R,Z)-2-methylhept-2-ene-1,6-diol (3), along with twenty-four known compounds (4-27). Their structures were determined by spectroscopic data analyses. All isolated compounds were subjected to bioactivity assays. In these, 1 specifically inhibited matrix metalloproteinase-2 activity with an IC 50 value of 16.3 ± 1.6 µM, while its analogue 1,2,3,6-tetra-O-galloyl-β-D-glucopyranonoside (17) inhibited matrix metalloproteinase-2 with an IC 50 value of 23.0 ± 4.8 µM. In the collagenase activity assay, the inhibitory effects of 1 and 17 at concentrations of both 20 and 40 µM were more potent than those of the positive control, 1,10-phenanthroline. In order to realize whether 17 could penetrate from the epidermal layer into the basal and dermal layers of the human skin to inhibit the activity of matrix metalloproteinase-2 and collagenase or not, a transdermal penetration test in nude and white mice skins was performed. Penetration percentages of 17 quantified by LC-MS were 27.8 % and 74.8 % in 24 hours, respectively. Supporting information available online at

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Anti-MMP-2 Activity and Skin-Penetrating Capability of the Chemical Constituents from Rhodiola rosea

et al. 2016

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“…The therapeutic compounds isolated from this plant have anti-diabetic (Cheng et al, 1993), sedative, hypnotic, anti inflammatory, anti-oxidant potential (Choe et al, 2012;Lee et al, 2000) and hepatoprotective effects (Nan et al, 2003b). The root extract has protective effect in the liver injury of rat model induced by continuous administration of CCl4.…”

Section: Rhodiola Sachalinensismentioning

confidence: 99%

Anti-fibrotic activity of medicinal plants

Akhtar

Ahmad

2017

Bangladesh J Pharmacol

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<p class="Abstract">The aim of this review is to report the medicinal plants which have anti- fibrotic effect characterized in different studies. They are summarized which include name of the plants, part used, liver fibrosis model, fraction of plant used and observations. The medicinal plants play an important role in treatment and prevention of liver fibrosis through different physiological mechanism. The effects of medicinal plant may delay the development of liver fibrosis and have potential to reverse or degrade the accumulation of extra cellular matrix. Four different databases are used and 18 plants are included which have the potential for reversal of liver fibrosis. There are also few more plants but they are not characterized well in literature.</p>

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“…19 Moreover, Rhodiola extract contains other antioxidant compounds such as p-tyrosol, organic acids (gallic and caffeic acids), and flavonoids (catechins and proanthocyanidins). 16,37,38 Indeed, there is experimental evidence that treatment of spontaneously hypertensive rats (SHR) with Rhodiola increased the superoxide dismutase activity. 39 Clearly, the anti-inflammatory and antioxidant attributes of Rhodiola can be expected to yield therapeutic benefits in PH.…”

Section: Rhodiola In Ph: Illusionary or Promising?mentioning

confidence: 99%

Rhodiola: An Ordinary Plant or a Promising Future Therapy for Pulmonary Hypertension? A Brief Review

et al. 2013

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Pulmonary hypertension (PH) is a chronic, complex, and progressive disease that eventuates in fatality. Research efforts over the past decades have resulted in therapeutic options that improve quality of life and prolong survival of patients, but they do not offer a cure. We propose a philosophical model that a disturbed balance of yin and yang results in pulmonary vascular remodeling, the hallmark of PH pathology. The model may be useful in exploring the wisdom of traditional Chinese medicine and incorporating it into mainstream PH research. In this context, the medicinal plant Rhodiola can be of profound interest owing to its variety of health-friendly attributes. Rhodiola has been shown to be beneficial in high-altitude-related symptoms and acute exacerbation of PH; moreover, improvement of PH has been demonstrated experimentally in chronically hypoxic rats. The beneficial effects of Rhodiola in PH may be attributable to its potential targeting of the signaling pathways, such as endothelin-1, nitric oxide, vascular endothelial growth factor, angiotensin-converting enzyme, nuclear factor κ-B, tumor necrosis factor α, and interleukin-6. Alterations in these mediators are implicated in PH pathogenesis, the characteristics of which include chronic pulmonary vasoconstriction, vasoproliferation, and vascular inflammation. Salidroside, one of the compounds extracted from Rhodiola, has been found to provide therapeutic benefits in experimental PH. As the data are limited and the field is in its infancy, further studies including in-depth analysis of the therapeutic effects on various animal models of PH are desirable. We believe that future PH research should place an adequate and special emphasis on exploring and promoting the potential of traditional Chinese medicine, and to this end, the medicinal plant Rhodiola offers a promising field on which to embark.

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Antioxidative phenolic compounds from the roots ofRhodiola sachalinensis A. Bor

Cited by 95 publications

References 4 publications

Anti-MMP-2 Activity and Skin-Penetrating Capability of the Chemical Constituents from Rhodiola rosea

Anti-MMP-2 Activity and Skin-Penetrating Capability of the Chemical Constituents from Rhodiola rosea

Anti-fibrotic activity of medicinal plants

Rhodiola: An Ordinary Plant or a Promising Future Therapy for Pulmonary Hypertension? A Brief Review

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