Antiperiodontitis Effects of Magnolia biondii Extract on Ligature-Induced Periodontitis in Rats

Abstract

Over the past decades, periodontitis has become a rising health problem and caused various diseases. In the many studies shows that some extracts and compound to the prevention and treatment of periodontitis. This study focuses on the effects of inhibition of gingival damage and alveolar bone loss. The aim of this study was to evaluate the protective effects of Magnolia biondii extract (MBE) against ligature-induced periodontitis in rats. A ligature was placed around the molar teeth for 8 weeks, and MBE was administered for 8 weeks. Gingival tissue damage and alveolar bone loss were measured by microcomputed tomography (CT) analysis and histopathological examination. Serum Interluekin-1 β (IL-1β), tumor necrosis factor-α (TNF-α), cyclooxygenases-2 (COX-2), and receptor activator of nuclear factor–κB ligand (RANKL) levels were investigated using commercial kits to confirm the antiperiodontitis effects of MBE. We confirmed that ligature-induced periodontitis resulted in gingival tissue damage and alveolar bone loss. However, treatment for 8 weeks with MBE protected from periodontal tissue damage and downregulated serum inflammatory cytokine factors and RANKL levels. These results suggest that MBE exerts antiperiodontitis effects by inhibiting gingival tissue destruction and alveolar bone loss through regulation of anti-inflammatory cytokines in periodontitis-induced rats.

Ultrastructural Study of the Effect of Curcumin Nanoparticles Administration on the Alveolar Bone Structure in Rats With Induced Periodontitis

“…Induction of periodontitis in the current study was performed by using 4-0 silk ligature for 2 weeks. This is in accordance to Moraes et al (2020) (25) and other researchers (26,27) who used silk ligatures to induce experimental periodontitis because it is a simple, effective, cheap and an available method. In addition, Kurt et al (14) proved that tying silk ligatures around the experimental rats' mandibular first molars for 2 weeks was capable to create an experimental periodontitis model.…”

Патоморфологічні Прояви У Пародонті При Експериментальному Опіоїдному Впливі Упродовж Шести Тижнів Та Після Його Чотиритижневої Відміни

“…Необхідно зазначити, що для проведення діагностики та розробки оптимальної схеми терапії при даній патології необхідні ґрунтовні дослідження структурної організації складових компонентів пародонта на різних термінах дії опіоїдів та подальшої відміни цих чинників [9]. При цьому, як відзначають дослідники, експериментальне моделювання патологічних станів на тваринах і досі залишається актуальним [10,11]. Усе вищезазначене зумовило напрямок експериментального дослідження.…”

Efficacy of bubaline blood derived fibrin glue in silk ligature-induced acute periodontitis in Wistar rats

“…Pro-inflammatory cytokines, Tnfa and Il1b , have been shown to initiate bone resorption in periodontal diseases [ 51 , 52 ]. Tnfa levels in rats with periodontitis are significantly higher than those of normal rats after 6 weeks of ligature induction [ 53 , 54 ]. The present study revealed that bubaline fibrin glue treatment led to decreased mRNA expression of Tnfa and Il1b in a time-dependent manner, and a significant difference was noted compared to the non-treatment control.…”