Antiphospholipid antibody: laboratory, pathogenesis and clinical manifestations

Tincani, Anǵela; Casu, Cinzia; Cartella, S.; Ziglioli, Tamara; Cattaneo, Roberto

doi:10.4081/reumatismo.2010.65

Cited by 10 publications

(9 citation statements)

References 51 publications

(62 reference statements)

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“…Besides the Classical Lupus Anticoagulant (LAC) and Anti-Cardiolipin Antibodies (ACA), other antiPhospholipid Antibodies (aPL) were shown to target anionic phospholipids and other plasma proteins, including phosphatidylethanolamine, protein C, protein S, ß2-Glycoprotein I (beta2-gpI) and annexin V (Tincani et al, 2010).…”

Section: And Lowmentioning

confidence: 99%

Anti-Phosphatidylserine Antibodies in Acute Myocardial Infarction

Jahromi¹,

Shojaei²,

Farjam³

et al. 2013

American Journal of Immunology

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Acute Myocardial Infarction (AMI) is the combined result of environmental factors and personal predispositions. Many factors play a role in AMI including anti-Phospholipid (aPL) antibodies, that may act in the induction of immunological response leading to the development of AMI. AntiPhosphatidylserine (PS) antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study of anti-PS antibody in AMI might shed light on etiologic mechanisms in the pathogenesis of acute coronary syndromes. This study was conducted to evaluate whether prevalence of anti-PS antibodies, in patients who had AMI and to analyze their relationship with traditional cardiovascular risk factors. The prevalence of anti-PS IgG and IgM in a well characterized group of patients with AMI as a case group and in age and sex matched healthy subjects as control group. Sera from two groups were tested to evaluate the presence of IgG and IgM isotypes to anti-PS by ELISA method. The frequencies of positive test for anti-PS IgG were 26.70 and 8.90% among patients and controls respectively with significant difference (p = 0.003). The anti-PS IgM frequencies were 12.20 and 1.10% in patients and the controls, with significant difference (p = 0.005). The findings of this study suggest that anti-PS antibodies seemed to play a role in AMI, independent risk factors for AMI, which may represent a link between autoimmunity and atherosclerosis in patients with AMI. Further studies with bigger sample size including patients with AMI and healthy people are recommended to explore the exact role of anti-PS antibodies in AMI.

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Section: And Lowmentioning

confidence: 99%

Anti-Phosphatidylserine Antibodies in Acute Myocardial Infarction

Jahromi¹,

Shojaei²,

Farjam³

et al. 2013

American Journal of Immunology

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“…As this antibody is categorized in antiphosohlipid antibodies (Tincani et al, 2010) and also ACA was suggested as risk factor for RSA in the same area (Jahromi et al, 2002), it may be other antiphosohlipid antibodies are participating in RSA in this area.…”

Section: Resultsmentioning

confidence: 99%

“…It has been suggested that aPL may be responsible for a local acute inflammatory response mediated by complement activation (Sotoudeh Jahromi, 2007a;Meroni et al, 2010) and neutrophil infiltration eventually leading to fetal loss (Meroni et al, 2010). In addition to the Classical Lupus Anticoagulant (LAC) and AntiCardiolipin Antibodies (ACA), other anti-Phospholipid Antibodies (aPL) were shown to target anionic phospholipids and other plasma proteins, including phosphatidylethanolamine, protein C, protein S, ß 2 -Glycoprotein I (GPI) and annexin V (Tincani et al, 2010). In spite of their presence, the accurate mechanism by which aPLs precipitate fetal loss is unclear, but may include inducing prothrombotic events in the uteroplacental vasculature (Matsubayashi et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Anti β<sub>2</sub>-Glycoprotein I Antibodies in Women with Recurrent Spontaneous Abortion

Jahromi¹

2010

American Journal of Biochemistry and Biotechnology

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Problem statement: Antiphospholipid antibodies (aPL) are associated with repeated miscarriages and pregnancy complications, however their pathogenic mechanisms are still matter of research. Anti-β 2 glycoprotein 1 (β 2 GPI) antibody is one of these aPL that its contribution to RSA risk remains poorly understood. There were not any data about role this auto-antibody in RSA in South of Iran. This study was conducted to assess Anti-β 2 GPI IgM and IgG as RSA risk factors for RSA in this area of Iran. Approach: This case-control study was carried out in gynecology special hospital of Hormozgan University of medical sciences, during [2004][2005]. A number of 250 women with >3 consecutive idiopathic pregnancy losses as a case group and 200 age matched women with normal full term delivery and negative history of miscarriage as a controls were studied. All obtained sera from the case and the control groups were tested using an Enzyme Linked Immunosorbent Assay (ELISA) method for detection of anti-β 2 GPI IgM and IgG. Data was analyzed, using SAS 8 statistical software (chi square and t-test). Results: There were significant differences between the prevalence of positive anti-β 2 GPI IgM (p = 0.01) and IgG (p = 0.02) in the case group and the control group. A positive significant relationship was observed in the case group between number of abortion and seropositivity for anti-β 2 GPI IgG (p = 0.028, r = +0.181) and anti-β 2 GPI IgM (p = 0.0381, r = +0.014). Conclusion: This study showed anti-ß 2 GPI antibodies are important causative agent for RSA in this area of Iran.

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“…In addition to the Classical Lupus Anticoagulant (LAC) and Anti-Cardiolipin Abs (ACA), other antiPhospholipid Abs (aPL) were presented to target anionic phospholipids and other plasma proteins, counting phosphatidyl inositol, protein C, protein S, ß2-Glycoprotein I (beta2-gpI) and annexin V (Tincani et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of Anti-Phosphatidyl Inositole Antibodies in Patients With Myocardial Infarction and Healthy Subjects

Jahromi¹

2014

American Journal of Immunology

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Immune system and inflamation is widely known to play a key role in the development and progression of cardiovascular diseases. Anti-Phospholipid (aPL) antibodies may act in the induction of immunological response leading to the development of Acute Myocardial Infarction (AMI). Anti-Phosphatidyl Inositole (PI) Antibody (Ab) has been seen in various diseases including rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. Although there are a few studies on the association of some autoantibodies with AMI, more epidemiological data are required to confirm their significance as independent risk factors in cardiovascular diseases. Moreover, the data on the relationship of autoantibodies with traditional risk factors of AMI is rare. The study of anti-PI Ab in AMI may lead to understand of etiology of ischemic heart disease. This study was conducted to determine whether prevalence of anti-PI Abs, in patients who had AMI and to analyze their association with traditional cardiovascular risk factors. The prevalence of anti-PI IgG and IgM in a well characterized group of patients with AMI as a case group and in age and sex matched healthy subjects as control group. Sera from the case and the control groups were tested to evaluate the presence of IgG and IgM isotypes to anti-PI by ELISA method. The prevalence of anti-PI IgG and also IgM in the case group resulted significantly higher than in the control group with AMI (p<0.005). The findings of this study suggest that anti-PI Abs seemed to have a role in AMI independent risk factors for AMI and may represent a link between autoimmunity and atherosclerosis in patients with AMI. Comprehensive studies are recommended to explore the exact role of anti-PI Abs in AMI.

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Antiphospholipid antibody: laboratory, pathogenesis and clinical manifestations

Cited by 10 publications

References 51 publications

Anti-Phosphatidylserine Antibodies in Acute Myocardial Infarction

Anti-Phosphatidylserine Antibodies in Acute Myocardial Infarction

Anti β<sub>2</sub>-Glycoprotein I Antibodies in Women with Recurrent Spontaneous Abortion

A Comparative Study of Anti-Phosphatidyl Inositole Antibodies in Patients With Myocardial Infarction and Healthy Subjects

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