Antiplaque and antigingivitis efficacy of toothpastes containing Triclosan and fluoride

Abstract

Objective: To compare the reduction of plaque and gingivitis from the following three toothpaste formulations containing: 0.3% Triclosan, 1,000ppm fluoride and 0.13% calcium glycerophosphate in a natural calcium carbonate base (a new paste); 0.2% Triclosan and 1,000ppm fluoride in a precipitated calcium carbonate base; 0.3% Triclosan, 1,000ppm fluoride and Gantrez in a silica base. A control group was maintained, which used commercially available toothpastes without the above actives. Methods: A double‐blind, four‐cell, stratified, parallel group design study. Subjects brushed twice daily with their allocated toothpaste for 12 weeks. Plaque, MGI and gingival bleeding assessments were carried out at baseline, after 6 and 12 weeks of product use. Results and conclusion: An analysis of covariance of the 12‐week results showed significant differences between products [p<0.0001] for plaque, MGI and gingival bleeding. The new toothpaste formulation containing 0.3% Triclosan, 1,000ppm fluoride and 0.13% calcium glycerophosphate in a natural calcium carbonate base was shown to be significantly more effective in reducing plaque and gingivitis than the other toothpaste formulations in the study.

On the Need and Speed of Regulating Triclosan and Triclocarban in the United States

“…With respect to TCS and TCC, scientific evidence points to known benefits from their application in health care settings by health care professionals, and possibly from TCS-containing toothpaste used by individuals diagnosed with gingivitis. 149 Exclusive sale of TCS/TCC-containing soaps in pharmacies and prescription requirements for TCS in toothpaste may aid in effecting the desirable reduction in unsustainable consumption patterns and with it associated adverse effects. This tiered approach worked well for the now restricted hexachlorophene, whose allowable and prudent applications continue to this date, as a preservative at concentrations of up to 0.1% by weight.…”

The role of Triclosan in dentifrice formulations, with particular reference to a new 0.3% Triclosan calcium carbonate-based system

“…In-vivo, Triclosan's clinical efficacy has been enhanced by combining it either with a copolymer of polyvinyl methyl ether (PVM) and maleic acid (MA) (trade name Gantrez‚), marketed as Colgate Total (Colgate-Palmolive) 29,[41][42][43][44][45] or with zinc citrate as an additional compatible antimicrobial agent, marketed under the Mentadent, Aim, Signal and Pepsodent brands (Unilever Oral Care) 12,14,16,20,46,47 . However, Triclosan does deliver effective clinical efficacy on its own 48,49 and recent work has shown that when present in calcium carbonate-based systems as the sole antimicrobial agent, Triclosan does show measurable in-vitro (as discussed below) and in-vivo activity 50 .…”

“…In Asia, where calcium carbonate is the abrasive of choice in toothpaste formulations, Triclosan is used as the sole antimicrobial agent in a number of dentifrices. 50 .…”

PAMAM dendrimers for the delivery of the antibacterial Triclosan

“…This yielded the fully conjugated G0:4 N-Boc-L-phenylalanine (4) (77.8 mg, 0.052 mmol, 51.5% yield). 1 H NMR indicated approx 75% purity (from integration of Ph CH 2 CH peaks of reacted and unreacted phenylalanine) with separation from the unreacted phenylalanine difficult due to the small difference in molecular weight between the compounds. Partial G3 PAMAM 2-(tert-butyloxycarbonylamino)-3-phenylpropanoate conjugates.…”

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AbstractMany oral care products incorporate an antibacterial compound to prevent the formation of dental plaque which predisposes teeth to dental caries or periodontal disease [1]. Triclosan (TCN) is a commonly used antiplaque agent in toothpastes [2,3].

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